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Slc18a1 solute carrier family 18 member A1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25693, updated on 17-Aug-2024

Summary

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Official Symbol
Slc18a1provided by RGD
Official Full Name
solute carrier family 18 member A1provided by RGD
Primary source
RGD:3693
See related
EnsemblRapid:ENSRNOG00000011992 AllianceGenome:RGD:3693
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CGAT; VMAT-1
Summary
Enables enzyme binding activity and serotonin:sodium symporter activity. Involved in cellular response to lithium ion; regulation of ion transport; and serotonin uptake. Located in cytoplasm. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human SLC18A1 (solute carrier family 18 member A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 81.2) See more
Orthologs
human mouse all
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Genomic context

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Location:
16p14
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (25408485..25453786)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (20653268..20687051)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (22358646..22395183)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene leucine zipper tumor suppressor 1 Neighboring gene uncharacterized LOC102554171 Neighboring gene ATPase H+ transporting V1 subunit B2 Neighboring gene ribosomal protein S10-like 2 Neighboring gene small nucleolar RNA SNORA70

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Lithium ions Up-regulate mRNAs encoding dense-core vesicle proteins in nerve growth factor-differentiated PC12 cells. Cordeiro ML, et al. J Neurochem, 2000 Dec. PMID 11080216
  2. Differences in the expression of catecholamine-synthesizing enzymes between vesicular monoamine transporter 1- and 2-immunoreactive glomus cells in the rat carotid body. Kato K, et al. Acta Histochem, 2020 Apr. PMID 31955909
  3. VMAT1 deletion causes neuronal loss in the hippocampus and neurocognitive deficits in spatial discrimination. Multani PK, et al. Neuroscience, 2013 Mar 1. PMID 23201251, Free PMC Article
  4. Induction of VMAT-1 and TPH-1 expression induces vesicular accumulation of serotonin and protects cells and tissue from cooling/rewarming injury. Talaei F, et al. PLoS One, 2012. PMID 22253933, Free PMC Article
  5. Association between polymorphisms in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) on chromosome 8p and schizophrenia. Lohoff FW, et al. Neuropsychobiology, 2008. PMID 18451639

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Differences in the expression of catecholamine-synthesizing enzymes between vesicular monoamine transporter 1- and 2-immunoreactive glomus cells in the rat carotid body.
    Title: Differences in the expression of catecholamine-synthesizing enzymes between vesicular monoamine transporter 1- and 2-immunoreactive glomus cells in the rat carotid body.
  2. Transfection of VMAT-1 and TPH-1 induced vesicular storage of serotonin which is triggered release upon cooling and has protective effects against hypothermia.
    Title: Induction of VMAT-1 and TPH-1 expression induces vesicular accumulation of serotonin and protects cells and tissue from cooling/rewarming injury.
  3. First step toward the comprehension of the role of the VMAT-1 transporter in renal dopamine handling and its involvement in pathological situations.
    Title: Vesicular monoamine transporter 1 mediates dopamine secretion in rat proximal tubular cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables monoamine:proton antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoamine:proton antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables monoamine:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables serotonin:sodium:chloride symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serotonin:sodium:chloride symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables xenobiotic transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aminergic neurotransmitter loading into synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to lithium ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in dopamine uptake ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of serotonin uptake IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in norepinephrine uptake ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dopamine secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in serotonin uptake IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in serotonin uptake IEA
Inferred from Electronic Annotation
more info
  
involved_in serotonin uptake ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in secretory granule membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
chromaffin granule amine transporter
Names
VAT1
VMAT1
solute carrier family 18 (vesicular monoamine transporter), member 1
solute carrier family 18 (vesicular monoamine), member 1
solute carrier family 18 member 1
solute carrier family18 (vesicular monoamine) member 1 (chromaffin granule amine transporter)
vesicular amine transporter 1
vesicular monoamine transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013152.2 → NP_037284.2  chromaffin granule amine transporter

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016, M97380
    UniProtKB/Swiss-Prot
    Q01818
    UniProtKB/TrEMBL
    F1LSA7
    Related
    ENSRNOP00000016193.2, ENSRNOT00000016193.5
    Conserved Domains (3) summary
    cd06174
    Location:299 → 475
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00880
    Location:137 → 278
    2_A_01_02; Multidrug resistance protein
    pfam07690
    Location:136 → 442
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    25408485..25453786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275099.1 → XP_063131169.1  chromaffin granule amine transporter isoform X1

    UniProtKB/Swiss-Prot
    Q01818
    UniProtKB/TrEMBL
    F1LSA7

  2. XM_039094220.2 → XP_038950148.1  chromaffin granule amine transporter isoform X2

    UniProtKB/Swiss-Prot
    Q01818
    Conserved Domains (1) summary
    cd17384
    Location:34 → 424
    MFS_SLC18A1_2_VAT1_2; Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily

  3. XM_063275103.1 → XP_063131173.1  chromaffin granule amine transporter isoform X3

  4. XM_063275104.1 → XP_063131174.1  chromaffin granule amine transporter isoform X4

    UniProtKB/TrEMBL
    A6KU71

  5. XM_063275101.1 → XP_063131171.1  chromaffin granule amine transporter isoform X1

    UniProtKB/Swiss-Prot
    Q01818
    UniProtKB/TrEMBL
    F1LSA7

  6. XM_063275102.1 → XP_063131172.1  chromaffin granule amine transporter isoform X1

    UniProtKB/Swiss-Prot
    Q01818
    UniProtKB/TrEMBL
    F1LSA7

  7. XM_063275100.1 → XP_063131170.1  chromaffin granule amine transporter isoform X1

    UniProtKB/Swiss-Prot
    Q01818
    UniProtKB/TrEMBL
    F1LSA7

RNA

  1. XR_010058277.1 RNA Sequence

  2. XR_010058278.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01818.1 GenPept UniProtKB/Swiss-Prot:Q01818

Gene LinkOut

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