U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SNX33 sorting nexin 33 [ Homo sapiens (human) ]

Gene ID: 257364, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
SNX33provided by HGNC
Official Full Name
sorting nexin 33provided by HGNC
Primary source
HGNC:HGNC:28468
See related
Ensembl:ENSG00000173548 MIM:619107; AllianceGenome:HGNC:28468
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNX30; SH3PX3; SH3PXD3C
Summary
The protein encoded by this gene is involved in cytoskeletal reorganization, vesicle trafficking, endocytosis, and mitosis. The encoded protein is essential for the creation of the cleavage furrow during mitosis and for completion of mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in esophagus (RPKM 14.6), ovary (RPKM 14.1) and 24 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
15q24.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (75647912..75662301)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (73518620..73533009)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75940253..75954642)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene snurportin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6675 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9859 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6676 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:75940037-75940728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75943426-75944362 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75945327-75945879 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75945880-75946431 Neighboring gene IMP U3 small nucleolar ribonucleoprotein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75949231-75949732 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75949733-75950232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75952205-75952778 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:75953927-75954500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75966659-75967446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75974798-75975642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75978522-75979027 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75979028-75979532 Neighboring gene chondroitin sulfate proteoglycan 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75985202-75985952 Neighboring gene Sharpr-MPRA regulatory region 4583 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75989701-75990450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75990451-75991198 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6679 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75993083-75993582 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75993590-75994515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9863 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:76019661-76020161 Neighboring gene ciliary microtubule associated protein 1C Neighboring gene dynamin 1 pseudogene 35

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. [Donepezil Reduces Amyloid Precursor Protein Endocytosis by Resulting from Increase in the Expression of Sorting Nexin Protein 33]. Takada-Takatori Y. Yakugaku Zasshi, 2021. PMID 34078793
  2. The SNX-PX-BAR family in macropinocytosis: the regulation of macropinosome formation by SNX-PX-BAR proteins. Wang JT, et al. PLoS One, 2010 Oct 29. PMID 21048941, Free PMC Article
  3. Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33. Dislich B, et al. Biochem J, 2011 Jan 1. PMID 20964629
  4. Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins. Kleino I, et al. J Cell Biochem, 2009 Nov 1. PMID 19718658
  5. Sorting nexin 33 induces mammalian cell micronucleated phenotype and actin polymerization by interacting with Wiskott-Aldrich syndrome protein. Zhang J, et al. J Biol Chem, 2009 Aug 7. PMID 19487689, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [Donepezil Reduces Amyloid Precursor Protein Endocytosis by Resulting from Increase in the Expression of Sorting Nexin Protein 33].
    Title: [Donepezil Reduces Amyloid Precursor Protein Endocytosis by Resulting from Increase in the Expression of Sorting Nexin Protein 33].
  2. The sorting nexin 9 (SNX9) subfamily members - SNX9, SNX18 and SNX33 - are required for progression and completion of mitosis.
    Title: SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis.
  3. study identifies critical amino acids within the BAR domains of SNX9 and SNX33 as determinants for the specificity of BAR domain-mediated interactions and suggests that SNX9 and SNX33 have distinct molecular functions.
    Title: Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33.
  4. Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins SNX33 and nephrocystin
    Title: Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins.
  5. SNX33 plays a role in maintaining cell shape and cell cycle progression through its interaction with WASp
    Title: Sorting nexin 33 induces mammalian cell micronucleated phenotype and actin polymerization by interacting with Wiskott-Aldrich syndrome protein.
  6. SNX33 interferes with cellular PrP formation by modulation of PrP shedding
    Title: The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding.
  7. identifies SNX33 as a new endocytic protein, which modulates amyloid precursor protein endocytosis and APP alpha-secretase cleavage, and demonstrates that the rate of APP endocytosis is a major control factor for APP alpha-secretase cleavage
    Title: A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC32065

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cleavage furrow formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cleavage furrow formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosomal transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in macropinocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of protein localization to cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in plasma membrane tubulation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plasma membrane tubulation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of membrane protein ectodomain proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein localization to cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein import IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
sorting nexin-33
Names
SH3 and PX domain containing 3
SH3 and PX domain-containing protein 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318146.1 → NP_001305075.1  sorting nexin-33 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK091291, BC018775
    UniProtKB/Swiss-Prot
    Q8WV41
    Conserved Domains (3) summary
    cd11896
    Location:4 → 58
    SH3_SNX33; Src Homology 3 domain of Sorting Nexin 33
    cl02563
    Location:230 → 354
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl12013
    Location:365 → 497
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. NM_153271.2 → NP_695003.1  sorting nexin-33 isoform 1

    See identical proteins and their annotated locations for NP_695003.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC105020
    Consensus CDS
    CCDS10283.1
    UniProtKB/Swiss-Prot
    B1NM17, Q8WV41
    Related
    ENSP00000311427.6, ENST00000308527.6
    Conserved Domains (3) summary
    cd07669
    Location:365 → 571
    BAR_SNX33; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 33
    cd11896
    Location:4 → 58
    SH3_SNX33; Src Homology 3 domain of Sorting Nexin 33
    cl02563
    Location:230 → 354
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    75647912..75662301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    73518620..73533009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WV41.1 GenPept UniProtKB/Swiss-Prot:Q8WV41

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous