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KIAA1549L KIAA1549 like [ Homo sapiens (human) ]

Gene ID: 25758, updated on 3-Apr-2024

Summary

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Official Symbol
KIAA1549Lprovided by HGNC
Official Full Name
KIAA1549 likeprovided by HGNC
Primary source
HGNC:HGNC:24836
See related
Ensembl:ENSG00000110427 MIM:612297; AllianceGenome:HGNC:24836
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G2; C11orf41; C11orf69
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 13.2) and skin (RPKM 0.8) See more
Orthologs
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Genomic context

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Location:
11p13
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (33376108..33674102)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (33511580..33811113)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (33397654..33695648)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3232 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3233 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4575 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4576 Neighboring gene ribosomal protein S24 pseudogene 15 Neighboring gene homeodomain interacting protein kinase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3236 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3237 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3238 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4577 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4578 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4579 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:33666983-33667484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:33667485-33667984 Neighboring gene uncharacterized LOC105376617 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:33676703-33677902 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4582 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:33711673-33712872 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3240 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4583 Neighboring gene chromosome 11 open reading frame 91 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3241 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3243 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:33795080-33795580 Neighboring gene Sharpr-MPRA regulatory region 12829 Neighboring gene CD59 molecule (CD59 blood group) Neighboring gene F-box protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genetic Influences on Evening Preference Overlap with Those for Bipolar Disorder in a Sample of Mexican Americans and American Indians. Melroy-Greif WE, et al. Twin Res Hum Genet, 2017 Dec. PMID 29192581, Free PMC Article
  2. PAX5-KIAA1549L: a novel fusion gene in a case of pediatric B-cell precursor acute lymphoblastic leukemia. Anderl S, et al. Mol Cytogenet, 2015. PMID 26157485, Free PMC Article
  3. A genome-wide association study of attempted suicide. Willour VL, et al. Mol Psychiatry, 2012 Apr. PMID 21423239, Free PMC Article
  4. Image-based genome-wide siRNA screen identifies selective autophagy factors. Orvedahl A, et al. Nature, 2011 Dec 1. PMID 22020285, Free PMC Article
  5. USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma. Saha G, et al. Oncogene, 2022 Nov. PMID 36243803

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of attempted suicide.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ36988, MGC34830

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UPF0606 protein KIAA1549L
Names
UPF0606 protein C11orf41
uncharacterized protein C11orf69

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410965.1 → NP_001397894.1  UPF0606 protein KIAA1549L isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL049575, AL049629, AL122015
    Consensus CDS
    CCDS91457.1
    UniProtKB/TrEMBL
    H0YDE5
    Related
    ENSP00000433481.3, ENST00000526400.7

  2. NM_012194.3 → NP_036326.3  UPF0606 protein KIAA1549L isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL049575, AL049629, AL122015, BC025668, DA034273, U10991
    Consensus CDS
    CCDS44565.3
    UniProtKB/Swiss-Prot
    B0QYU0, Q6ZVL6
    UniProtKB/TrEMBL
    A0A590UJI0
    Related
    ENSP00000499430.1, ENST00000658780.2
    Conserved Domains (2) summary
    PHA03247
    Location:6 → 418
    PHA03247; large tegument protein UL36; Provisional
    pfam12877
    Location:1228 → 1866
    DUF3827; Domain of unknown function (DUF3827)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    33376108..33674102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426719.1 → XP_047282675.1  UPF0606 protein KIAA1549L isoform X1

  2. XM_005252848.4 → XP_005252905.2  UPF0606 protein KIAA1549L isoform X2

  3. XM_047426720.1 → XP_047282676.1  UPF0606 protein KIAA1549L isoform X3

  4. XM_005252847.4 → XP_005252904.2  UPF0606 protein KIAA1549L isoform X5

    UniProtKB/TrEMBL
    Q12914
    Conserved Domains (2) summary
    PHA03255
    Location:607 → 741
    PHA03255; BDLF3; Provisional
    pfam12877
    Location:976 → 1614
    DUF3827; Domain of unknown function (DUF3827)

  5. XM_017017486.2 → XP_016872975.1  UPF0606 protein KIAA1549L isoform X7

  6. XM_047426721.1 → XP_047282677.1  UPF0606 protein KIAA1549L isoform X4

  7. XM_047426722.1 → XP_047282678.1  UPF0606 protein KIAA1549L isoform X6

    Related
    ENSP00000265654.6, ENST00000265654.6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    33511580..33811113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368332.1 → XP_054224307.1  UPF0606 protein KIAA1549L isoform X1

  2. XM_054368333.1 → XP_054224308.1  UPF0606 protein KIAA1549L isoform X2

  3. XM_054368334.1 → XP_054224309.1  UPF0606 protein KIAA1549L isoform X3

  4. XM_054368336.1 → XP_054224311.1  UPF0606 protein KIAA1549L isoform X5

  5. XM_054368338.1 → XP_054224313.1  UPF0606 protein KIAA1549L isoform X7

  6. XM_054368335.1 → XP_054224310.1  UPF0606 protein KIAA1549L isoform X4

  7. XM_054368337.1 → XP_054224312.1  UPF0606 protein KIAA1549L isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZVL6.2 GenPept UniProtKB/Swiss-Prot:Q6ZVL6

Gene LinkOut

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