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Cenpf centromere protein F [ Rattus norvegicus (Norway rat) ]

Gene ID: 257649, updated on 28-Oct-2024

Summary

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Official Symbol
Cenpfprovided by RGD
Official Full Name
centromere protein Fprovided by RGD
Primary source
RGD:628667
See related
EnsemblRapid:ENSRNOG00000003388 AllianceGenome:RGD:628667
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lek1
Summary
Predicted to enable DNA-binding transcription factor binding activity; dynein complex binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including metaphase chromosome alignment; regulation of G2/M transition of mitotic cell cycle; and ventricular system development. Predicted to act upstream of or within regulation of striated muscle tissue development. Predicted to be located in several cellular components, including cytoskeleton; midbody; and nucleus. Predicted to be part of ciliary transition fiber and outer kinetochore. Predicted to be active in chromosome, centromeric region; nucleus; and spindle pole. Human ortholog(s) of this gene implicated in Stromme syndrome. Orthologous to human CENPF (centromere protein F). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Thymus (RPKM 202.4), Spleen (RPKM 142.4) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cenpf in Genome Data Viewer
Location:
13q26
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (103715344..103760931, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (101184127..101229714, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (108132499..108178609, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548648 Neighboring gene transmembrane protein 14C like 1 Neighboring gene potassium two pore domain channel subfamily K member 2 Neighboring gene wiskott-Aldrich syndrome protein homolog 1-like Neighboring gene protein tyrosine phosphatase, non-receptor type 14 Neighboring gene SET and MYND domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Therapeutic effects of acupuncture in rheumatoid arthritis are associated with centromere protein F expression. Dong W, et al. Allergol Immunopathol (Madr), 2022. PMID 35527655
  2. CENP-F is a .ca 400 kDa kinetochore protein that exhibits a cell-cycle dependent localization. Rattner JB, et al. Cell Motil Cytoskeleton, 1993. PMID 7904902
  3. Unstable microtubule capture at kinetochores depleted of the centromere-associated protein CENP-F. Bomont P, et al. EMBO J, 2005 Nov 16. PMID 16252009, Free PMC Article
  4. The C terminus of mitosin is essential for its nuclear localization, centromere/kinetochore targeting, and dimerization. Zhu X, et al. J Biol Chem, 1995 Aug 18. PMID 7642639
  5. Silencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death. Yang Z, et al. Mol Cell Biol, 2005 May. PMID 15870278, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Therapeutic effects of acupuncture in rheumatoid arthritis are associated with centromere protein F expression.
    Title: Therapeutic effects of acupuncture in rheumatoid arthritis are associated with centromere protein F expression.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables dynein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein complex binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in kidney development ISO
Inferred from Sequence Orthology
more info
  
involved_in metaphase chromosome alignment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of striated muscle tissue development ISO
Inferred from Sequence Orthology
more info
  
involved_in ventricular system development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in chromosome, centromeric region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
part_of ciliary transition fiber ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
NOT located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of outer kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in pronucleus ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
centromere protein F
Names
LEK/centromere protein
centromere autoantigen F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100827.2 → NP_001094297.2  centromere protein F isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

  2. NM_001433858.1 → NP_001420787.1  centromere protein F isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    103715344..103760931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090400.2 → XP_038946328.1  centromere protein F isoform X2

    UniProtKB/TrEMBL
    E9PT83
    Conserved Domains (5) summary
    COG1196
    Location:1917 → 2692
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:285 → 1108
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10473
    Location:2293 → 2432
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    pfam10481
    Location:1 → 297
    CENP-F_N; Cenp-F N-terminal domain
    pfam10490
    Location:2846 → 2879
    CENP-F_C_Rb_bdg; Rb-binding domain of kinetochore protein Cenp-F/LEK1

  2. XM_039090398.2 → XP_038946326.1  centromere protein F isoform X1

    UniProtKB/TrEMBL
    E9PT83
    Related
    ENSRNOP00000004525.8, ENSRNOT00000004525.8
    Conserved Domains (6) summary
    COG1196
    Location:1917 → 2692
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:285 → 1108
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10473
    Location:2293 → 2432
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    pfam10481
    Location:1 → 297
    CENP-F_N; Cenp-F N-terminal domain
    pfam10490
    Location:2851 → 2884
    CENP-F_C_Rb_bdg; Rb-binding domain of kinetochore protein Cenp-F/LEK1
    cl27170
    Location:1517 → 1661
    DUF460; Protein of unknown function (DUF460)

  3. XM_039090399.2 → XP_038946327.1  centromere protein F isoform X1

    UniProtKB/TrEMBL
    E9PT83
    Conserved Domains (6) summary
    COG1196
    Location:1917 → 2692
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:285 → 1108
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10473
    Location:2293 → 2432
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    pfam10481
    Location:1 → 297
    CENP-F_N; Cenp-F N-terminal domain
    pfam10490
    Location:2851 → 2884
    CENP-F_C_Rb_bdg; Rb-binding domain of kinetochore protein Cenp-F/LEK1
    cl27170
    Location:1517 → 1661
    DUF460; Protein of unknown function (DUF460)

  4. XM_063272055.1 → XP_063128125.1  centromere protein F isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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