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RAB26 RAB26, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 25837, updated on 2-Nov-2024

Summary

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Official Symbol
RAB26provided by HGNC
Official Full Name
RAB26, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:14259
See related
Ensembl:ENSG00000167964 MIM:605455; AllianceGenome:HGNC:14259
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
V46133
Summary
Members of the RAB protein family, including RAB26, are important regulators of vesicular fusion and trafficking. The RAB family of small G proteins regulates intercellular vesicle trafficking, including exocytosis, endocytosis, and recycling (summary by Seki et al., 2000 [PubMed 11043516]).[supplied by OMIM, Nov 2010]
Expression
Broad expression in brain (RPKM 4.5), salivary gland (RPKM 3.5) and 15 other tissues See more
Orthologs
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Genomic context

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See RAB26 in Genome Data Viewer
Location:
16p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (2148144..2154165)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (2170604..2176626)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2198145..2204166)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene polycystin 1, transient receptor potential channel interacting Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2183282-2184050 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7026 Neighboring gene microRNA 3180-5 Neighboring gene microRNA 4516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2193122-2193873 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2196523-2197074 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2197627-2198178 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2198179-2198728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2198729-2199280 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2199281-2199832 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2199833-2200384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2200385-2200934 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2200935-2201486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10255 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7033 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10256 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2206391-2206972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2206973-2207556 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2207557-2208138 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2209305-2209887 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2209888-2210469 Neighboring gene small nucleolar RNA, C/D box 60 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2212971-2213472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2213473-2213972 Neighboring gene small nucleolar RNA host gene 19 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2214382-2215155 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2215156-2215928 Neighboring gene TNF receptor associated factor 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2227829-2228330 Neighboring gene CASK interacting protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ROS induced the Rab26 promoter hypermethylation to promote cigarette smoking-induced airway epithelial inflammation of COPD through activation of MAPK signaling. He BF, et al. Free Radic Biol Med, 2023 Feb 1. PMID 36610560
  2. cDNA cloning of a human RAB26-related gene encoding a Ras-like GTP-binding protein on chromosome 16p13.3 region. Seki N, et al. J Hum Genet, 2000. PMID 11043516
  3. RAB26 coordinates lysosome traffic and mitochondrial localization. Jin RU, et al. J Cell Sci, 2014 Mar 1. PMID 24413166, Free PMC Article
  4. Rab26 suppresses migration and invasion of breast cancer cells through mediating autophagic degradation of phosphorylated Src. Liu H, et al. Cell Death Dis, 2021 Mar 17. PMID 33731709, Free PMC Article
  5. A GCC repeat in RAB26 undergoes natural selection in human and harbors divergent genotypes in late-onset Alzheimer's disease. Alizadeh S, et al. Gene, 2024 Jan 30. PMID 37931854

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A GCC repeat in RAB26 undergoes natural selection in human and harbors divergent genotypes in late-onset Alzheimer's disease.
    Title: A GCC repeat in RAB26 undergoes natural selection in human and harbors divergent genotypes in late-onset Alzheimer's disease.
  2. ROS induced the Rab26 promoter hypermethylation to promote cigarette smoking-induced airway epithelial inflammation of COPD through activation of MAPK signaling.
    Title: ROS induced the Rab26 promoter hypermethylation to promote cigarette smoking-induced airway epithelial inflammation of COPD through activation of MAPK signaling.
  3. RAB26 contributes to the progression of non-small cell lung cancer after being transcriptionally activated by SMAD3.
    Title: RAB26 contributes to the progression of non-small cell lung cancer after being transcriptionally activated by SMAD3.
  4. Rab26 suppresses migration and invasion of breast cancer cells through mediating autophagic degradation of phosphorylated Src.
    Title: Rab26 suppresses migration and invasion of breast cancer cells through mediating autophagic degradation of phosphorylated Src.
  5. Rab26 selectively directs synaptic and secretory vesicles into preautophagosomal structures.
    Title: The GTPase Rab26 links synaptic vesicles to the autophagy pathway.
  6. Increased RAB26 expression causes lysosomes to coalesce in a central, perinuclear region within the cell.
    Title: RAB26 coordinates lysosome traffic and mitochondrial localization.
  7. The small GTPase Rab26 regulates the Golgi to cell surface traffic of alpha(2)-adrenergic receptors, likely through a physical interaction.
    Title: Rab26 modulates the cell surface transport of α2-adrenergic receptors from the Golgi.
  8. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  10. MIST1 binds to highly conserved CATATG E-boxes to directly activate transcription of 6 genes, including those encoding the small GTPases RAB26 and RAB3D.
    Title: RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GMP binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocrine system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocrine system development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulated exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation protein catabolic process at presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation protein catabolic process at presynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in secretory granule membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic vesicle membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
ras-related protein Rab-26
Names
Ras-related oncogene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308053.1 → NP_001294982.1  ras-related protein Rab-26 isoform 2

    See identical proteins and their annotated locations for NP_001294982.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and uses a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AB027137, AC009065, AK314110
    Consensus CDS
    CCDS76806.1
    UniProtKB/Swiss-Prot
    Q9ULW5
    Related
    ENSP00000441580.1, ENST00000541451.5
    Conserved Domains (1) summary
    cd04112
    Location:1 → 188
    Rab26; Rab GTPase family 26 (Rab26)

  2. NM_014353.5 → NP_055168.2  ras-related protein Rab-26 isoform 1

    See identical proteins and their annotated locations for NP_055168.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC009065
    Consensus CDS
    CCDS10460.1
    UniProtKB/Swiss-Prot
    B2RAA6, Q3L6K5, Q6NXS7, Q9ULW5
    Related
    ENSP00000210187.6, ENST00000210187.11
    Conserved Domains (1) summary
    cd04112
    Location:64 → 254
    Rab26; Rab GTPase family 26 (Rab26)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    2148144..2154165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    2170604..2176626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ULW5.3 GenPept UniProtKB/Swiss-Prot:Q9ULW5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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