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MOB4 MOB family member 4, phocein [ Homo sapiens (human) ]

Gene ID: 25843, updated on 5-Mar-2024

Summary

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Official Symbol
MOB4provided by HGNC
Official Full Name
MOB family member 4, phoceinprovided by HGNC
Primary source
HGNC:HGNC:17261
See related
Ensembl:ENSG00000115540 MIM:609361; AllianceGenome:HGNC:17261
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
2C4D; MOB1; MOB3; PHOCN; PREI3; CGI-95; MOBKL3
Summary
This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene activation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HSPE1.[provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in adrenal (RPKM 20.9), esophagus (RPKM 14.5) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
2q33.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (197515554..197553699)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (197999154..198037300)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (198380278..198418423)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 105B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12213 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16939 Neighboring gene HSPE1-MOB4 readthrough Neighboring gene heat shock protein family D (Hsp60) member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12215 Neighboring gene heat shock protein family E (Hsp10) member 1 Neighboring gene uncharacterized LOC124907952 Neighboring gene RNY5 pseudogene 2 Neighboring gene NANOG hESC enhancer GRCh37_chr2:198447337-198447852 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:198451577-198452275 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:198452276-198452973 Neighboring gene raftlin family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16940 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:198484019-198484523 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:198484980-198485480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16941 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:198532470-198533059 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:198533060-198533648 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16943 Neighboring gene methionyl-tRNA synthetase 2, mitochondrial

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Phocein: A potential actor in vesicular trafficking at Purkinje cell dendritic spines. Bailly YJ, et al. Cerebellum, 2007. PMID 17853115
  2. hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme. Tang F, et al. Cancer Res, 2014 Jul 15. PMID 24872389, Free PMC Article
  3. Cryo-EM structure of the Hippo signaling integrator human STRIPAK. Jeong BC, et al. Nat Struct Mol Biol, 2021 Mar. PMID 33633399, Free PMC Article
  4. The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer. Chen M, et al. J Biol Chem, 2018 Sep 14. PMID 30072378, Free PMC Article
  5. A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes. Moreno CS, et al. J Biol Chem, 2001 Jun 29. PMID 11319234, Free PMC Article

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mob4 is essential for spermatogenesis in Drosophila melanogaster.
    Title: Mob4 is essential for spermatogenesis in Drosophila melanogaster.
  2. Because of divergent evolution of key interface residues, MST4 and MOB4 could disrupt assembly of the MST1-MOB1 complex through alternative pairing and thereby increased YAP activity. Collectively, these findings identify the MST4-MOB4 complex as a noncanonical regulator of the Hippo-YAP pathway with an oncogenic role in PC
    Title: The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer.
  3. hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme.
    Title: hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme.
  4. phosphorylation of MOB1 at Thr74 by MST2 is essential to make a complex of MOB1, MST2 and NDR1, and to fully activate NDR1
    Title: Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC12264

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MOB-like protein phocein
Names
MOB1, Mps One Binder kinase activator-like 3
Mps One Binder kinase activator-like 3
class II mMOB1
mob1 homolog 3
phocein, Mob-like protein
preimplantation protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100819.3 → NP_001094289.1  MOB-like protein phocein isoform 3

    See identical proteins and their annotated locations for NP_001094289.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC020550, AK297514, BC005237, CR736874
    Consensus CDS
    CCDS46480.1
    UniProtKB/TrEMBL
    A8K012
    Related
    ENSP00000405354.2, ENST00000448447.6
    Conserved Domains (1) summary
    pfam03637
    Location:32 → 186
    Mob1_phocein; Mob1/phocein family

  2. NM_001204094.1 → NP_001191023.1  MOB-like protein phocein isoform 2

    See identical proteins and their annotated locations for NP_001191023.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate exon at its 5' end compared to variant 1, resulting in a different 5' UTR and translation initiation at a downstream start codon. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same isoform (2).
    Source sequence(s)
    AC020550, AK292938, CR736874, DC375649
    Consensus CDS
    CCDS2322.1
    UniProtKB/TrEMBL
    A8K012
    Related
    ENSP00000387289.1, ENST00000409360.1
    Conserved Domains (1) summary
    pfam03637
    Location:21 → 175
    Mob1_phocein; Mob1/phocein family

  3. NM_015387.5 → NP_056202.2  MOB-like protein phocein isoform 1

    See identical proteins and their annotated locations for NP_056202.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC020550, BC005237, CR736874
    Consensus CDS
    CCDS2321.1
    UniProtKB/Swiss-Prot
    B4DML0, Q53SE0, Q7Z4Y6, Q9H2P3, Q9H5J1, Q9Y3A3, Q9Y4T8
    UniProtKB/TrEMBL
    A8K012
    Related
    ENSP00000315702.4, ENST00000323303.9
    Conserved Domains (1) summary
    pfam03637
    Location:53 → 207
    Mob1_phocein; Mob1/phocein family

  4. NM_199482.4 → NP_955776.1  MOB-like protein phocein isoform 2

    See identical proteins and their annotated locations for NP_955776.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate exon at its 5' end compared to variant 1, resulting in a different 5' UTR and translation initiation at a downstream start codon. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same isoform (2).
    Source sequence(s)
    AC020550, AF250319, AL080070, CR736874, DC298610
    Consensus CDS
    CCDS2322.1
    UniProtKB/TrEMBL
    A8K012
    Related
    ENSP00000233892.4, ENST00000233892.8
    Conserved Domains (1) summary
    pfam03637
    Location:21 → 175
    Mob1_phocein; Mob1/phocein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    197515554..197553699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    197999154..198037300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y3A3.1 GenPept UniProtKB/Swiss-Prot:Q9Y3A3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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