U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

BRMS1 BRMS1 transcriptional repressor and anoikis regulator [ Homo sapiens (human) ]

Gene ID: 25855, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
BRMS1provided by HGNC
Official Full Name
BRMS1 transcriptional repressor and anoikis regulatorprovided by HGNC
Primary source
HGNC:HGNC:17262
See related
Ensembl:ENSG00000174744 MIM:606259; AllianceGenome:HGNC:17262
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 18.9), testis (RPKM 16.4) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See BRMS1 in Genome Data Viewer
Location:
11q13.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (66337339..66345104, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (66330994..66338767, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66104810..66112575, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66083264-66083960 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3588 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:66086517-66087018 Neighboring gene CD248 molecule Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:66087019-66087518 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66093768-66094517 Neighboring gene Ras and Rab interactor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66104385-66105239 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:66112315-66112865 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3589 Neighboring gene beta-1,4-glucuronyltransferase 1 Neighboring gene tRNA-Ser (anticodon GCT) 3-1 Neighboring gene B4GAT1 divergent transcript

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Distinct expression and function of breast cancer metastasis suppressor 1 in mutant P53 glioblastoma. Babu D, et al. Cell Oncol (Dordr), 2022 Dec. PMID 36284039
  2. The isolated C-terminal nuclear localization sequence of the breast cancer metastasis suppressor 1 is disordered. Pantoja-Uceda D, et al. Arch Biochem Biophys, 2019 Mar 30. PMID 30707944, Free PMC Article
  3. Breast cancer metastasis suppressor gene, breast cancer metastasis suppressor 1, may be associated with clinicopathological features of breast cancer. Lin L, et al. J Cancer Res Ther, 2018 Jun. PMID 29970691
  4. BRMS1 Expression in Surgically Resected Lung Adenocarcinoma Predicts Future Metastases and Is Associated with a Poor Prognosis. Bucciarelli PR, et al. J Thorac Oncol, 2018 Jan. PMID 29097253, Free PMC Article
  5. BRMS1 gene expression may be associated with clinico-pathological features of breast cancer. Lin LZ, et al. Biosci Rep, 2017 Aug 31. PMID 28533425, Free PMC Article

See all (124) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Distinct expression and function of breast cancer metastasis suppressor 1 in mutant P53 glioblastoma.
    Title: Distinct expression and function of breast cancer metastasis suppressor 1 in mutant P53 glioblastoma.
  2. A germline SNP in BRMS1 predisposes patients with lung adenocarcinoma to metastasis and can be ameliorated by targeting c-fos.
    Title: A germline SNP in BRMS1 predisposes patients with lung adenocarcinoma to metastasis and can be ameliorated by targeting c-fos.
  3. N6-Methyladenosine modification of the TRIM7 positively regulates tumorigenesis and chemoresistance in osteosarcoma through ubiquitination of BRMS1.
    Title: N6-Methyladenosine modification of the TRIM7 positively regulates tumorigenesis and chemoresistance in osteosarcoma through ubiquitination of BRMS1.
  4. suggest that BRMS! NLS2 is a disordered region, with non pre-formed structure, that participates in metastasis suppression
    Title: The isolated C-terminal nuclear localization sequence of the breast cancer metastasis suppressor 1 is disordered.
  5. BRMS1 gene expression and anti-metastatic role in the breast cancer.
    Title: Additive effect of metastamiR-193b and breast cancer metastasis suppressor 1 as an anti-metastatic strategy.
  6. BRMS1FANCI interaction is necessary for the regulatory role of BRMS1 in the FA pathway.
    Title: BRMS1 participates in regulating cell sensitivity to DNA interstrand crosslink damage by interacting with FANCI.
  7. overexpression of miR-3200-5p significantly decreased BRMS1 levels and promoted OS cell invasion and migration, while depletion of miR-3200-5p significantly increased BRMS1 levels and inhibited OS cell invasion and migration. Study revealed that miR-3200-5p may be a critical regulator of OS cell invasiveness.
    Title: MicroRNA-3200-5p Promotes Osteosarcoma Cell Invasion via Suppression of BRMS1.
  8. Low BRMS1 expression is associated with Hepatocellular carcinoma.
    Title: miR-346 Promotes HCC Progression by Suppressing Breast Cancer Metastasis Suppressor 1 Expression.
  9. Low BRMS1 expression is associated with high metastatic capacity of breast cancer.
    Title: Breast cancer metastasis suppressor gene, breast cancer metastasis suppressor 1, may be associated with clinicopathological features of breast cancer.
  10. High BRMS1 Expression is associated with Metastases and recurrence in Lung Adenocarcinoma.
    Title: BRMS1 Expression in Surgically Resected Lung Adenocarcinoma Predicts Future Metastases and Is Associated with a Poor Prognosis.
Submit: New GeneRIF Correction See all GeneRIFs (77)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • DKFZp564A063

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NF-kappaB binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell migration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of anoikis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein deacetylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of Sin3-type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
breast cancer metastasis-suppressor 1
Names
breast cancer metastasis suppressor 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024957.2 → NP_001020128.1  breast cancer metastasis-suppressor 1 isoform 2

    See identical proteins and their annotated locations for NP_001020128.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' terminal exon which results in the use of a downstream stop codon, compared to variant 1. The encoded protein (isoform 2) has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AP001107, BM312965, CB130346, CB529276
    Consensus CDS
    CCDS44654.1
    UniProtKB/TrEMBL
    E9PJF5, G5E9I4
    Related
    ENSP00000396052.2, ENST00000425825.6
    Conserved Domains (1) summary
    pfam08598
    Location:60 → 177
    Sds3; Sds3-like

  2. NM_015399.4 → NP_056214.1  breast cancer metastasis-suppressor 1 isoform 1

    See identical proteins and their annotated locations for NP_056214.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest and more abundant transcript and encodes isoform (1).
    Source sequence(s)
    AP001107, BU734281, CB130346
    Consensus CDS
    CCDS8135.1
    UniProtKB/Swiss-Prot
    Q6IAI2, Q9HCU9
    UniProtKB/TrEMBL
    E9PJF5
    Related
    ENSP00000353042.3, ENST00000359957.8
    Conserved Domains (1) summary
    pfam08598
    Location:60 → 178
    Sds3; Sds3-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    66337339..66345104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448426.2 → XP_024304194.1  breast cancer metastasis-suppressor 1 isoform X2

    UniProtKB/TrEMBL
    E9PJF5
    Conserved Domains (1) summary
    pfam08598
    Location:60 → 178
    Sds3; Sds3-like

  2. XM_024448425.2 → XP_024304193.1  breast cancer metastasis-suppressor 1 isoform X1

    UniProtKB/TrEMBL
    H0YCF7
    Related
    ENSP00000431510.1, ENST00000524699.5
    Conserved Domains (1) summary
    pfam08598
    Location:60 → 178
    Sds3; Sds3-like

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    66330994..66338767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368347.1 → XP_054224322.1  breast cancer metastasis-suppressor 1 isoform X2

  2. XM_054368346.1 → XP_054224321.1  breast cancer metastasis-suppressor 1 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001024958.1: Suppressed sequence

    Description
    NM_001024958.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HCU9.1 GenPept UniProtKB/Swiss-Prot:Q9HCU9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous