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Art5 ADP-ribosyltransferase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 259167, updated on 18-Sep-2024

Summary

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Official Symbol
Art5provided by RGD
Official Full Name
ADP-ribosyltransferase 5provided by RGD
Primary source
RGD:628834
See related
EnsemblRapid:ENSRNOG00000020242 AllianceGenome:RGD:628834
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ARTC5
Summary
Predicted to enable NAD+ ADP-ribosyltransferase activity and NAD+ nucleosidase activity. Predicted to be involved in peptidyl-arginine ADP-ribosylation. Predicted to act upstream of or within protein ADP-ribosylation. Predicted to be located in extracellular region and membrane. Orthologous to human ART5 (ADP-ribosyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 238.1), Testes (RPKM 33.8) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Art5 in Genome Data Viewer
Location:
1q32
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (165885344..165895306, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (156473362..156483324, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (167192809..167202767, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 121 Neighboring gene Xrcc1 N-terminal domain containing 1 Neighboring gene transient receptor potential cation channel subfamily C member 2 Neighboring gene ADP-ribosyltransferase 1 Neighboring gene cholinergic receptor nicotinic alpha 10 subunit Neighboring gene nucleoporin 98 and 96 precursor Neighboring gene glutathione peroxidase 4, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a novel membrane-associated lymphocyte NAD:arginine ADP-ribosyltransferase. Okazaki IJ, et al. J Biol Chem, 1996 Sep 6. PMID 8703012
  2. Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5. Glowacki G, et al. Gene, 2001 Sep 19. PMID 11587854
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+-protein-arginine ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ecto-ADP-ribosyltransferase 5
Names
ADP-ribosyltransferase C2 and C3 toxin-like 5
NAD(P)(+)--arginine ADP-ribosyltransferase 5
mono(ADP-ribosyl)transferase 5
NP_001013057.1
XP_006229907.1
XP_017444328.1
XP_038958275.1
XP_038958304.1
XP_038958309.1
XP_038958319.1
XP_063138431.1
XP_063138435.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013039.1 → NP_001013057.1  ecto-ADP-ribosyltransferase 5 precursor

    See identical proteins and their annotated locations for NP_001013057.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083915
    UniProtKB/Swiss-Prot
    Q5XHY4
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 255
    ART; NAD:arginine ADP-ribosyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    165885344..165895306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229845.5 → XP_006229907.1  ecto-ADP-ribosyltransferase 5 isoform X1

    See identical proteins and their annotated locations for XP_006229907.1

    UniProtKB/TrEMBL
    A0A8L2QQ22, A6I715
    Related
    ENSRNOP00000052118.3, ENSRNOT00000055243.4
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 255
    ART; NAD:arginine ADP-ribosyltransferase

  2. XM_039102376.2 → XP_038958304.1  ecto-ADP-ribosyltransferase 5 isoform X3

    Conserved Domains (1) summary
    pfam01129
    Location:1 → 209
    ART; NAD:arginine ADP-ribosyltransferase

  3. XM_039102391.2 → XP_038958319.1  ecto-ADP-ribosyltransferase 5 isoform X5

    Conserved Domains (1) summary
    cl00173
    Location:29 → 202
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  4. XM_039102381.2 → XP_038958309.1  ecto-ADP-ribosyltransferase 5 isoform X4

    Conserved Domains (1) summary
    cl00173
    Location:29 → 209
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  5. XM_063282361.1 → XP_063138431.1  ecto-ADP-ribosyltransferase 5 isoform X2

    UniProtKB/Swiss-Prot
    Q5XHY4

  6. XM_039102347.2 → XP_038958275.1  ecto-ADP-ribosyltransferase 5 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QQ22, A6I715
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 255
    ART; NAD:arginine ADP-ribosyltransferase

  7. XM_017588839.3 → XP_017444328.1  ecto-ADP-ribosyltransferase 5 isoform X2

    UniProtKB/Swiss-Prot
    Q5XHY4
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 255
    ART; NAD:arginine ADP-ribosyltransferase

  8. XM_063282365.1 → XP_063138435.1  ecto-ADP-ribosyltransferase 5 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XHY4.1 GenPept UniProtKB/Swiss-Prot:Q5XHY4

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