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MRGPRX1 MAS related GPR family member X1 [ Homo sapiens (human) ]

Gene ID: 259249, updated on 11-Apr-2024

Summary

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Official Symbol
MRGPRX1provided by HGNC
Official Full Name
MAS related GPR family member X1provided by HGNC
Primary source
HGNC:HGNC:17962
See related
Ensembl:ENSG00000170255 MIM:607227; AllianceGenome:HGNC:17962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPCR; MGRG2; MRGX1; SNSR4
Summary
Enables transmembrane signaling receptor activity. Involved in cell surface receptor signaling pathway and response to chloroquine. Predicted to be located in cell surface. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
11p15.1; 11
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (18933499..18939414, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (19031499..19037414, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (18955046..18960961, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MAS related GPR family member X6, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr11:18921836-18922341 Neighboring gene NANOG hESC enhancer GRCh37_chr11:18934386-18934891 Neighboring gene MAS related GPR family member X5, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:18943059-18943558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:18964603-18965104 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:18977428-18977928 Neighboring gene NANOG hESC enhancer GRCh37_chr11:18979998-18980547 Neighboring gene MAS related GPR family member X11, pseudogene Neighboring gene MAS related GPR family member X10, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanism of agonist-induced activation of the human itch receptor MRGPRX1. Gan B, et al. PLoS Biol, 2023 Jun. PMID 37347749, Free PMC Article
  2. BAM8-22 and its receptor MRGPRX1 may attribute to cholestatic pruritus. Sanjel B, et al. Sci Rep, 2019 Jul 26. PMID 31350433, Free PMC Article
  3. Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain. Li Z, et al. Proc Natl Acad Sci U S A, 2017 Mar 7. PMID 28223516, Free PMC Article
  4. Pruriception and neuronal coding in nociceptor subtypes in human and nonhuman primates. Klein A, et al. Elife, 2021 Apr 23. PMID 33891544, Free PMC Article
  5. Tick peptides evoke itch by activating MrgprC11/MRGPRX1 to sensitize TRPV1 in pruriceptors. Li X, et al. J Allergy Clin Immunol, 2021 Jun. PMID 33358893

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ligand recognition and G protein coupling of the human itch receptor MRGPRX1.
    Title: Ligand recognition and G protein coupling of the human itch receptor MRGPRX1.
  2. Mechanism of agonist-induced activation of the human itch receptor MRGPRX1.
    Title: Mechanism of agonist-induced activation of the human itch receptor MRGPRX1.
  3. Pruriception and neuronal coding in nociceptor subtypes in human and nonhuman primates.
    Title: Pruriception and neuronal coding in nociceptor subtypes in human and nonhuman primates.
  4. BAM8-22 and its receptor MRGPRX1 may attribute to cholestatic pruritus.
    Title: BAM8-22 and its receptor MRGPRX1 may attribute to cholestatic pruritus.
  5. Our findings established a novel function for Mrgprc11 in the gut nociceptive innervation
    Title: Mas-related G protein-coupled receptor C11 (Mrgprc11) induces visceral hypersensitivity in the mouse colon: A novel target in gut nociception?
  6. Study reports that a cysteine protease mucunain, active component of cowhage (itch-inducing spicules or trichomes that cover the seedpods of the tropical plant Mucuna pruriens) that is routinely used in human studies of histamine-independent itch, activates human MRGPRX1 and MRGPRX2 receptors and induces degranulation of human mast cells.
    Title: Mas-Related G-Protein Coupled Receptors and Cowhage-Induced Itch.
  7. MRGPRX1 is a promising target for pain inhibition, a humanized mouse model expressing this receptor has been described.
    Title: Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain.
  8. Der p1 also induced the release of IL-6 from heterologous cells expressing MRGPRX1. In summary, activation of Mrgprs by the allergen Der p1 may contribute to inflammation.
    Title: Activation of mas-related G-protein-coupled receptors by the house dust mite cysteine protease Der p1 provides a new mechanism linking allergy and inflammation.
  9. analysis of the functional interactions between MRGPR-X1 and TRPV1
    Title: Human sensory neuron-specific Mas-related G protein-coupled receptors-X1 sensitize and directly activate transient receptor potential cation channel V1 via distinct signaling pathways.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acute-phase response IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to chloroquine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IC
Inferred by Curator
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mas-related G-protein coupled receptor member X1
Names
G protein-coupled receptor MRGX1
G protein-coupled receptor SNSR3
MAS-related GPR, member X1
Mas-related G protein-coupled receptor G2
sensory neuron-specific G-protein coupled receptor 3/4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393578.1 → NP_001380507.1  mas-related G-protein coupled receptor member X1

    Status: VALIDATED

    Source sequence(s)
    AC023078
    Consensus CDS
    CCDS7846.1
    UniProtKB/Swiss-Prot
    Q4V9L2, Q8TDD8, Q8TDD9, Q96LB2
    UniProtKB/TrEMBL
    B5B0C6, W8W3P5
    Related
    ENSP00000499076.2, ENST00000526914.2
    Conserved Domains (1) summary
    cd15106
    Location:28 → 299
    7tmA_MrgprX-like; primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_147199.4 → NP_671732.3  mas-related G-protein coupled receptor member X1

    See identical proteins and their annotated locations for NP_671732.3

    Status: VALIDATED

    Source sequence(s)
    AC023078
    Consensus CDS
    CCDS7846.1
    UniProtKB/Swiss-Prot
    Q4V9L2, Q8TDD8, Q8TDD9, Q96LB2
    UniProtKB/TrEMBL
    B5B0C6, W8W3P5
    Related
    ENSP00000305766.3, ENST00000302797.4
    Conserved Domains (1) summary
    cd15106
    Location:28 → 299
    7tmA_MrgprX-like; primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    18933499..18939414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    19031499..19037414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96LB2.1 GenPept UniProtKB/Swiss-Prot:Q96LB2

Gene LinkOut

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