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crh-2 CREB homolog crh-2 [ Caenorhabditis elegans ]

Gene ID: 259434, updated on 2-Nov-2024

Summary

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Official Symbol
crh-2
Official Full Name
CREB homolog crh-2
Primary source
WormBase:WBGene00016162
Locus tag
CELE_C27D6.4
See related
AllianceGenome:WB:WBGene00016162
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and cAMP response element binding activity. Involved in defense response to Gram-negative bacterium; positive regulation of dauer entry; and regulation of gene expression. Predicted to be located in nucleus. Is expressed in several structures, including hypodermis; intestine; nervous system; pharynx; and spermatheca. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 16. Orthologous to several human genes including CREB3L1 (cAMP responsive element binding protein 3 like 1) and CREB3L2 (cAMP responsive element binding protein 3 like 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See crh-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
11
Sequence:
Chromosome: II; NC_003280.10 (5179026..5187569, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Multicopper oxidase;Secreted protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Major sperm protein 49

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Prediction pipeline for discovery of regulatory motifs associated with Brugia malayi molting. Grote A, et al. PLoS Negl Trop Dis, 2020 Jun. PMID 32574217, Free PMC Article
  2. Intergenerational Pathogen-Induced Diapause in Caenorhabditis elegans Is Modulated by mir-243. Gabaldón C, et al. mBio, 2020 Sep 22. PMID 32963007, Free PMC Article
  3. Co-regulation by Notch and Fos is required for cell fate specification of intermediate precursors during C. elegans uterine development. Oommen KS, et al. Development, 2007 Nov. PMID 17942488
  4. A genome-wide map of conserved microRNA targets in C. elegans. Lall S, et al. Curr Biol, 2006 Mar 7. PMID 16458514
  5. Maternal H3K36 and H3K27 HMTs protect germline development via regulation of the transcription factor LIN-15B. Cockrum CS, et al. Elife, 2022 Aug 3. PMID 35920536, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP response element binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of dauer entry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CREB homolog crh-2
NP_001293486.1
  • Confirmed by transcript evidence
NP_740985.2
  • Confirmed by transcript evidence
NP_740986.2
  • Confirmed by transcript evidence
NP_740987.4
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5179026..5187569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170988.7 → NP_740986.2  CREB homolog crh-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740986.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4JFI0
    Conserved Domains (1) summary
    cd14689
    Location:261 → 321
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

  2. NM_170989.11 → NP_740987.4  CREB homolog crh-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740987.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09636, Q4JFH9, Q4JFI0, Q95ZX9, S6FD32
    Conserved Domains (1) summary
    cd14689
    Location:283 → 343
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

  3. NM_170987.8 → NP_740985.2  CREB homolog crh-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_740985.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q09636
    Conserved Domains (1) summary
    cd14689
    Location:156 → 216
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

  4. NM_001306557.3 → NP_001293486.1  CREB homolog crh-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293486.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    S6FD32
    Conserved Domains (1) summary
    cd14689
    Location:151 → 211
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
Nucleotide Protein
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