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htp-1 HORMA domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 259571, updated on 2-Nov-2024

Summary

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Official Symbol
htp-1
Official Full Name
HORMA domain-containing protein
Primary source
WormBase:WBGene00002032
Locus tag
CELE_F41H10.10
See related
AllianceGenome:WB:WBGene00002032
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in regulation of centriole-centriole cohesion. Located in lateral element. Is expressed in Z2 and Z3. Orthologous to human HORMAD1 (HORMA domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See htp-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (5390189..5391557, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Long chain fatty acid elongase 6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ER membrane protein complex subunit 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crossovers trigger a remodeling of meiotic chromosome axis composition that is linked to two-step loss of sister chromatid cohesion. Martinez-Perez E, et al. Genes Dev, 2008 Oct 15. PMID 18923085, Free PMC Article
  2. The fidelity of synaptonemal complex assembly is regulated by a signaling mechanism that controls early meiotic progression. Silva N, et al. Dev Cell, 2014 Nov 24. PMID 25455309
  3. Phosphoregulation of HORMA domain protein HIM-3 promotes asymmetric synaptonemal complex disassembly in meiotic prophase in Caenorhabditis elegans. Sato-Carlton A, et al. PLoS Genet, 2020 Nov. PMID 33175901, Free PMC Article
  4. HTP-1-dependent constraints coordinate homolog pairing and synapsis and promote chiasma formation during C. elegans meiosis. Martinez-Perez E, et al. Genes Dev, 2005 Nov 15. PMID 16291646, Free PMC Article
  5. The conserved AAA ATPase PCH-2 distributes its regulation of meiotic prophase events through multiple meiotic HORMADs in C. elegans. Russo AE, et al. PLoS Genet, 2023 Apr. PMID 37058535, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ERK phosphorylates chromosomal axis component HORMA domain protein HTP-1 to regulate oocyte numbers.
    Title: ERK phosphorylates chromosomal axis component HORMA domain protein HTP-1 to regulate oocyte numbers.
  2. Block III (21 RNAs) was enriched for RNA-binding proteins, including previously validated FBF targets gld-1 and htp-1 We suggest that Block I RNAs belong to the FBF network for spermatogenesis, and that Blocks II and III are associated with stem cell functions.
    Title: Toward Identifying Subnetworks from FBF Binding Landscapes in Caenorhabditis Spermatogenic or Oogenic Germlines.
  3. HTP-1 functionally couples homolog alignment to its stabilization by synapsis by preventing the association of synaptonemal complex (SC) components with unaligned and immature chromosome axes
    Title: HTP-1 coordinates synaptonemal complex assembly with homolog alignment during meiosis in C. elegans.
  4. A model is proposed in which HTP-1 functions to establish or maintain multiple constraints that operate to ensure coordination of events leading to a successful outcome of meiotic prophase (chiasma formation)
    Title: HTP-1-dependent constraints coordinate homolog pairing and synapsis and promote chiasma formation during C. elegans meiosis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of centriole-centriole cohesion IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in lateral element IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
HORMA domain-containing protein
NP_500799.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    5390189..5391557 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068398.5 → NP_500799.2  HORMA domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500799.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20305
    Conserved Domains (1) summary
    pfam02301
    Location:38 → 240
    HORMA; HORMA domain
Nucleotide Protein
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