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HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 [ Homo sapiens (human) ]

Gene ID: 26091, updated on 3-Apr-2024

Summary

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Official Symbol
HERC4provided by HGNC
Official Full Name
HECT and RLD domain containing E3 ubiquitin protein ligase 4provided by HGNC
Primary source
HGNC:HGNC:24521
See related
Ensembl:ENSG00000148634 MIM:609248; AllianceGenome:HGNC:24521
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in lymph node (RPKM 8.1), adrenal (RPKM 7.4) and 25 other tissues See more
Orthologs
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Genomic context

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See HERC4 in Genome Data Viewer
Location:
10q21.3
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (67921905..68075283, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (68790646..68944156, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (69681662..69835040, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene SIRT1 promoter region Neighboring gene Sharpr-MPRA regulatory region 7890 Neighboring gene ribosomal protein L12 pseudogene 8 Neighboring gene sirtuin 1 Neighboring gene RPS3A pseudogene 38 Neighboring gene RNA, 7SL, cytoplasmic 220, pseudogene Neighboring gene POU class 5 homeobox 1 pseudogene 5 Neighboring gene MPRA-validated peak985 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2417 Neighboring gene uncharacterized LOC124902442 Neighboring gene myopalladin Neighboring gene uncharacterized LOC107984240 Neighboring gene RN7SK pseudogene 202

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1. Xu Y, et al. Protein Cell, 2019 Aug. PMID 30710319, Free PMC Article
  2. HERC4 Is Overexpressed in Hepatocellular Carcinoma and Contributes to the Proliferation and Migration of Hepatocellular Carcinoma Cells. Zheng Y, et al. DNA Cell Biol, 2017 Jun. PMID 28430527
  3. Expression of HERC4 in lung cancer and its correlation with clinicopathological parameters. Zeng WL, et al. Asian Pac J Cancer Prev, 2015. PMID 25684480
  4. SIRT1/HERC4 Locus Associated With Bisphosphonate-Induced Osteonecrosis of the Jaw: An Exome-Wide Association Analysis. Yang G, et al. J Bone Miner Res, 2018 Jan. PMID 28856724
  5. The ubiquitin ligase HERC4 suppresses MafA transcriptional activity triggered by GSK3β in myeloma by atypical K63-linked polyubiquitination. Zhang Z, et al. J Biol Chem, 2023 May. PMID 37028761, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HERC4 modulates ovarian cancer cell proliferation by regulating SMO-elicited hedgehog signaling.
    Title: HERC4 modulates ovarian cancer cell proliferation by regulating SMO-elicited hedgehog signaling.
  2. The ubiquitin ligase HERC4 suppresses MafA transcriptional activity triggered by GSK3beta in myeloma by atypical K63-linked polyubiquitination.
    Title: The ubiquitin ligase HERC4 suppresses MafA transcriptional activity triggered by GSK3β in myeloma by atypical K63-linked polyubiquitination.
  3. HERC4 is downregulated in NSCLC samples; HERC4 interacts with Smo reciprocally in NSCLC cells; knockdown of herc4 activates Hh pathway and promotes NSCLC cell proliferation. Taken together, our studies have demonstrated that HERC4 acts as a tumor suppressor via destabilizing the oncoprotein Smo
    Title: HERC4 exerts an anti-tumor role through destabilizing the oncoprotein Smo.
  4. The authors findings demonstrate that HERC4 is important for promoting tumorigenesis.
    Title: A miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1.
  5. the SIRT1/HERC4 locus on chromosome 10 was identified to be associated with intravenous (iv) bisphosphonates induced Osteonecrosis of the Jaw.
    Title: SIRT1/HERC4 Locus Associated With Bisphosphonate-Induced Osteonecrosis of the Jaw: An Exome-Wide Association Analysis.
  6. HERC4 has an effect on the occurrence and development of hepatoma carcinoma
    Title: HERC4 Is Overexpressed in Hepatocellular Carcinoma and Contributes to the Proliferation and Migration of Hepatocellular Carcinoma Cells.
  7. High HERC4 expression is associated with lung cancer.
    Title: Expression of HERC4 in lung cancer and its correlation with clinicopathological parameters.
  8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
  10. HERC4 ancestor emerged in nematodes and that the family expanded throughout evolution. The mRNA expression pattern of the HERC4 was found to be diverse in selected tissues and cells
    Title: The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of HECT and RLD domain containing E3 ubiquitin protein ligase 4 (HERC4) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1593, DKFZp564G092

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in fibrillar center IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
probable E3 ubiquitin-protein ligase HERC4
Names
HECT domain and RCC1-like domain-containing protein 4
HECT-type E3 ubiquitin transferase HERC4
hect domain and RLD 4
NP_001265114.1
NP_001265115.1
NP_001265116.1
NP_056416.2
NP_071362.1
XP_011537894.1
XP_011537895.1
XP_011537899.1
XP_016871530.1
XP_024303695.1
XP_024303696.1
XP_024303698.1
XP_047280946.1
XP_047280947.1
XP_047280948.1
XP_047280949.1
XP_047280951.1
XP_047280952.1
XP_047280953.1
XP_047280954.1
XP_047280955.1
XP_047280956.1
XP_047280957.1
XP_047280958.1
XP_054221433.1
XP_054221434.1
XP_054221435.1
XP_054221436.1
XP_054221437.1
XP_054221438.1
XP_054221439.1
XP_054221440.1
XP_054221441.1
XP_054221442.1
XP_054221443.1
XP_054221444.1
XP_054221445.1
XP_054221446.1
XP_054221447.1
XP_054221448.1
XP_054221449.1
XP_054221450.1
XP_054221451.1
XP_054221452.1
XP_054221453.1
XP_054221454.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278185.2 → NP_001265114.1  probable E3 ubiquitin-protein ligase HERC4 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AY650032, AY650033, BC018114
    Consensus CDS
    CCDS60541.1
    UniProtKB/TrEMBL
    A8K9U4
    Related
    ENSP00000416504.2, ENST00000412272.6
    Conserved Domains (3) summary
    smart00119
    Location:735 → 976
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:709 → 977
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:208 → 257
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  2. NM_001278186.2 → NP_001265115.1  probable E3 ubiquitin-protein ligase HERC4 isoform d

    See identical proteins and their annotated locations for NP_001265115.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons compared to variant 1, and one causes a frameshift. These differences cause translation initiation at a downstream AUG and result in an isoform (d) with a shorter and distinct N-terminus and lacking an alternate internal segment, compared to isoform 1.
    Source sequence(s)
    AY650032, BC018114
    UniProtKB/Swiss-Prot
    Q5GLZ8
    Conserved Domains (3) summary
    smart00119
    Location:472 → 791
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:446 → 792
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:5 → 53
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  3. NM_001278187.2 → NP_001265116.1  probable E3 ubiquitin-protein ligase HERC4 isoform e

    See identical proteins and their annotated locations for NP_001265116.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has an alternate 3'-most exon in place of most of the rest of the transcript compared to variant 1. The resulting isoform (e) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC024258, AY650034, BX101651
    Consensus CDS
    CCDS60542.1
    UniProtKB/Swiss-Prot
    Q5GLZ8
    Related
    ENSP00000422383.1, ENST00000492996.6
    Conserved Domains (1) summary
    COG5184
    Location:2 → 69
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

  4. NM_015601.4 → NP_056416.2  probable E3 ubiquitin-protein ligase HERC4 isoform b

    See identical proteins and their annotated locations for NP_056416.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    BC018114, BC039600, DB459623
    Consensus CDS
    CCDS7274.1
    UniProtKB/TrEMBL
    A8K9U4
    Related
    ENSP00000362804.4, ENST00000373700.9
    Conserved Domains (2) summary
    cd00078
    Location:701 → 1047
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cl27697
    Location:2 → 344
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  5. NM_022079.3 → NP_071362.1  probable E3 ubiquitin-protein ligase HERC4 isoform a

    See identical proteins and their annotated locations for NP_071362.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AY221963, BC015043, BC018114
    Consensus CDS
    CCDS41533.1
    UniProtKB/Swiss-Prot
    Q5GC98, Q5GC99, Q5GCA0, Q5GLZ8, Q8IXP9, Q9HCH9
    UniProtKB/TrEMBL
    A8K9U4
    Related
    ENSP00000378624.3, ENST00000395198.7
    Conserved Domains (2) summary
    cd00078
    Location:709 → 1055
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cl27697
    Location:2 → 344
    RCC1; Regulator of chromosome condensation (RCC1) repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    67921905..68075283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424999.1 → XP_047280955.1  probable E3 ubiquitin-protein ligase HERC4 isoform X11

  2. XM_017016041.3 → XP_016871530.1  probable E3 ubiquitin-protein ligase HERC4 isoform X10

    UniProtKB/TrEMBL
    A8K9U4

  3. XM_047424998.1 → XP_047280954.1  probable E3 ubiquitin-protein ligase HERC4 isoform X9

  4. XM_011539597.4 → XP_011537899.1  probable E3 ubiquitin-protein ligase HERC4 isoform X8

    UniProtKB/TrEMBL
    A8K9U4
    Conserved Domains (3) summary
    smart00119
    Location:638 → 957
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:612 → 958
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:232 → 281
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  5. XM_011539593.4 → XP_011537895.1  probable E3 ubiquitin-protein ligase HERC4 isoform X2

    UniProtKB/TrEMBL
    A8K9U4
    Conserved Domains (3) summary
    smart00119
    Location:751 → 1070
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:725 → 1071
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:232 → 281
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  6. XM_011539592.4 → XP_011537894.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

    UniProtKB/TrEMBL
    A8K9U4
    Conserved Domains (2) summary
    COG5184
    Location:2 → 368
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:733 → 1079
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  7. XM_024447930.2 → XP_024303698.1  probable E3 ubiquitin-protein ligase HERC4 isoform X3

    UniProtKB/Swiss-Prot
    Q5GC98, Q5GC99, Q5GCA0, Q5GLZ8, Q8IXP9, Q9HCH9
    UniProtKB/TrEMBL
    A8K9U4
    Conserved Domains (2) summary
    cd00078
    Location:709 → 1055
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cl27697
    Location:2 → 344
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  8. XM_047424990.1 → XP_047280946.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

  9. XM_047425000.1 → XP_047280956.1  probable E3 ubiquitin-protein ligase HERC4 isoform X11

  10. XM_047424992.1 → XP_047280948.1  probable E3 ubiquitin-protein ligase HERC4 isoform X4

  11. XM_024447927.2 → XP_024303695.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

    UniProtKB/TrEMBL
    A8K9U4
    Conserved Domains (2) summary
    COG5184
    Location:2 → 368
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:733 → 1079
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  12. XM_047424993.1 → XP_047280949.1  probable E3 ubiquitin-protein ligase HERC4 isoform X4

  13. XM_047424991.1 → XP_047280947.1  probable E3 ubiquitin-protein ligase HERC4 isoform X3

    UniProtKB/Swiss-Prot
    Q5GC98, Q5GC99, Q5GCA0, Q5GLZ8, Q8IXP9, Q9HCH9

  14. XM_024447928.2 → XP_024303696.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

    UniProtKB/TrEMBL
    A8K9U4
    Conserved Domains (2) summary
    COG5184
    Location:2 → 368
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:733 → 1079
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  15. XM_047424997.1 → XP_047280953.1  probable E3 ubiquitin-protein ligase HERC4 isoform X7

  16. XM_047424996.1 → XP_047280952.1  probable E3 ubiquitin-protein ligase HERC4 isoform X6

  17. XM_047424995.1 → XP_047280951.1  probable E3 ubiquitin-protein ligase HERC4 isoform X5

    Related
    ENSP00000277817.6, ENST00000277817.10

  18. XM_047425001.1 → XP_047280957.1  probable E3 ubiquitin-protein ligase HERC4 isoform X12

  19. XM_047425002.1 → XP_047280958.1  probable E3 ubiquitin-protein ligase HERC4 isoform X13

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    68790646..68944156 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365464.1 → XP_054221439.1  probable E3 ubiquitin-protein ligase HERC4 isoform X3

    UniProtKB/Swiss-Prot
    Q5GC98, Q5GC99, Q5GCA0, Q5GLZ8, Q8IXP9, Q9HCH9

  2. XM_054365476.1 → XP_054221451.1  probable E3 ubiquitin-protein ligase HERC4 isoform X11

  3. XM_054365459.1 → XP_054221434.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

  4. XM_054365466.1 → XP_054221441.1  probable E3 ubiquitin-protein ligase HERC4 isoform X3

    UniProtKB/Swiss-Prot
    Q5GC98, Q5GC99, Q5GCA0, Q5GLZ8, Q8IXP9, Q9HCH9

  5. XM_054365460.1 → XP_054221435.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

  6. XM_054365475.1 → XP_054221450.1  probable E3 ubiquitin-protein ligase HERC4 isoform X11

  7. XM_054365474.1 → XP_054221449.1  probable E3 ubiquitin-protein ligase HERC4 isoform X10

  8. XM_054365473.1 → XP_054221448.1  probable E3 ubiquitin-protein ligase HERC4 isoform X9

  9. XM_054365472.1 → XP_054221447.1  probable E3 ubiquitin-protein ligase HERC4 isoform X8

  10. XM_054365463.1 → XP_054221438.1  probable E3 ubiquitin-protein ligase HERC4 isoform X2

  11. XM_054365458.1 → XP_054221433.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

  12. XM_054365461.1 → XP_054221436.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

  13. XM_054365462.1 → XP_054221437.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

  14. XM_054365477.1 → XP_054221452.1  probable E3 ubiquitin-protein ligase HERC4 isoform X11

  15. XM_054365465.1 → XP_054221440.1  probable E3 ubiquitin-protein ligase HERC4 isoform X3

    UniProtKB/Swiss-Prot
    Q5GC98, Q5GC99, Q5GCA0, Q5GLZ8, Q8IXP9, Q9HCH9

  16. XM_054365467.1 → XP_054221442.1  probable E3 ubiquitin-protein ligase HERC4 isoform X4

  17. XM_054365468.1 → XP_054221443.1  probable E3 ubiquitin-protein ligase HERC4 isoform X4

  18. XM_054365471.1 → XP_054221446.1  probable E3 ubiquitin-protein ligase HERC4 isoform X7

  19. XM_054365470.1 → XP_054221445.1  probable E3 ubiquitin-protein ligase HERC4 isoform X6

  20. XM_054365469.1 → XP_054221444.1  probable E3 ubiquitin-protein ligase HERC4 isoform X5

  21. XM_054365478.1 → XP_054221453.1  probable E3 ubiquitin-protein ligase HERC4 isoform X12

  22. XM_054365479.1 → XP_054221454.1  probable E3 ubiquitin-protein ligase HERC4 isoform X13

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001017972.1: Suppressed sequence

    Description
    NM_001017972.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5GLZ8.1 GenPept UniProtKB/Swiss-Prot:Q5GLZ8

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