U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TIPRL TOR signaling pathway regulator [ Homo sapiens (human) ]

Gene ID: 261726, updated on 3-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
TIPRLprovided by HGNC
Official Full Name
TOR signaling pathway regulatorprovided by HGNC
Primary source
HGNC:HGNC:30231
See related
Ensembl:ENSG00000143155 MIM:611807; AllianceGenome:HGNC:30231
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIP; TIP41; TIPRL1
Summary
TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010]
Expression
Ubiquitous expression in endometrium (RPKM 11.7), brain (RPKM 11.6) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TIPRL in Genome Data Viewer
Location:
1q24.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (168178962..168202109)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (167530459..167553616)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (168148200..168171347)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:168025104-168025604 Neighboring gene Sharpr-MPRA regulatory region 7850 Neighboring gene GCSH pseudogene 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:168054775-168055275 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:168065654-168066154 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:168066155-168066655 Neighboring gene G protein-coupled receptor 161 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1542 Neighboring gene Sharpr-MPRA regulatory region 11959 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:168147823-168148324 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:168163898-168164682 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:168166417-168166917 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:168177413-168178005 Neighboring gene cytochrome c oxidase subunit NDUFA4-like Neighboring gene ribosomal protein L34 pseudogene 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. TIPRL, a Potential Double-edge Molecule to be Targeted and Re-targeted Toward Cancer. Gao J, et al. Cell Biochem Biophys, 2024 Sep. PMID 38888871
  2. Inhibition of MKK7-JNK by the TOR signaling pathway regulator-like protein contributes to resistance of HCC cells to TRAIL-induced apoptosis. Song IS, et al. Gastroenterology, 2012 Nov. PMID 22841785
  3. Genetic association and meta-analysis of a schizophrenia GWAS variant rs10489202 in East Asian populations. Yang Y, et al. Transl Psychiatry, 2018 Aug 7. PMID 30087317, Free PMC Article
  4. The positive correlation of TIPRL with LC3 and CD133 contributes to cancer aggressiveness: potential biomarkers for early liver cancer. Jun SY, et al. Sci Rep, 2019 Nov 14. PMID 31727942, Free PMC Article
  5. TIPRL potentiates survival of lung cancer by inducing autophagy through the eIF2α-ATF4 pathway. Jeon SJ, et al. Cell Death Dis, 2019 Dec 20. PMID 31862913, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TIPRL, a Potential Double-edge Molecule to be Targeted and Re-targeted Toward Cancer.
    Title: TIPRL, a Potential Double-edge Molecule to be Targeted and Re-targeted Toward Cancer.
  2. The positive correlation of TIPRL with LC3 and CD133 contributes to cancer aggressiveness: potential biomarkers for early liver cancer.
    Title: The positive correlation of TIPRL with LC3 and CD133 contributes to cancer aggressiveness: potential biomarkers for early liver cancer.
  3. TIPRL potentiates survival of lung cancer by inducing autophagy through the eIF2alpha-ATF4 pathway.
    Title: TIPRL potentiates survival of lung cancer by inducing autophagy through the eIF2α-ATF4 pathway.
  4. MPC2 rs10489202 was genome-wide significantly associated with schizophrenia. The expression quantitative trait loci analysis in lymphoblastoid cell lines from East Asian donors revealed that MPC2 rs10489202 was specifically and significantly associated with the expression of TIPRL gene.
    Title: Genetic association and meta-analysis of a schizophrenia GWAS variant rs10489202 in East Asian populations.
  5. overexpression of TIPRL promotes phosphorylation of H2AX, and increases gamma-H2AX positive foci in response to DNA damage, whereas knockdown of TIPRL inhibits gamma-H2AX phosphorylation
    Title: TIPRL Inhibits Protein Phosphatase 4 Activity and Promotes H2AX Phosphorylation in the DNA Damage Response.
  6. Unlike yeast TIP41, TIPRL has a positive effect on mTORC1 signaling through the association with PP2Ac.
    Title: A positive role of mammalian Tip41-like protein, TIPRL, in the amino-acid dependent mTORC1-signaling pathway through interaction with PP2A.
  7. Data indicate that PP2A holoenzyme biogenesis and activity are controlled by five PP2A modulators, consisting of alpha4, PTPA, LCMT1, PME-1 and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled.
    Title: The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity.
  8. TIPRL is highly up-regulated in human HCC samples and cell lines, compared with noncancerous liver tissues.
    Title: Inhibition of MKK7-JNK by the TOR signaling pathway regulator-like protein contributes to resistance of HCC cells to TRAIL-induced apoptosis.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC3794

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
TIP41-like protein
Names
TIP41, TOR signaling pathway regulator-like
putative MAPK-activating protein PM10
type 2A-interacting protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031800.3 → NP_001026970.1  TIP41-like protein isoform 2

    See identical proteins and their annotated locations for NP_001026970.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons, and uses an alternate 3'-terminal exon, compared to variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK313520, BC009506
    Consensus CDS
    CCDS30935.1
    UniProtKB/Swiss-Prot
    O75663
    Related
    ENSP00000356804.3, ENST00000367830.3
    Conserved Domains (1) summary
    pfam04176
    Location:56 → 172
    TIP41; TIP41-like family

  2. NM_152902.5 → NP_690866.1  TIP41-like protein isoform 1

    See identical proteins and their annotated locations for NP_690866.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK313520, AL021397
    Consensus CDS
    CCDS1270.1
    UniProtKB/Swiss-Prot
    B2R8V3, O75663, Q5HYB2, Q8IZ86
    Related
    ENSP00000356807.2, ENST00000367833.7
    Conserved Domains (1) summary
    pfam04176
    Location:50 → 218
    TIP41; TIP41-like family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    168178962..168202109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    167530459..167553616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75663.2 GenPept UniProtKB/Swiss-Prot:O75663

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools