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mt-Nd1 NADH dehydrogenase 1, mitochondrial [ Rattus norvegicus (Norway rat) ]

Gene ID: 26193, updated on 14-Nov-2024

Summary

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Official Symbol
mt-Nd1provided by RGD
Official Full Name
NADH dehydrogenase 1, mitochondrialprovided by RGD
Primary source
RGD:620555
See related
AllianceGenome:RGD:620555
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus (strain: BN/SsNHsdMCW)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ND1
Summary
Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to contribute to NADH dehydrogenase activity. Involved in several processes, including response to hydroperoxide; response to hypoxia; and response to xenobiotic stimulus. Located in dendrite and neuronal cell body. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including MELAS syndrome; neurodegenerative disease (multiple); optic nerve disease (multiple); toxic shock syndrome; and type 2 diabetes mellitus. Orthologous to human MT-ND1 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mt-Nd1 in Genome Data Viewer
Annotation release Status Assembly Chr Location
RS_2023_06 latest, but not current mRatBN7.2 (GCF_015227675.2) MT (non-nuclear) NC_001665.2 (2740..3694)
106 previous assembly Rnor_6.0 (GCF_000001895.5) MT (non-nuclear) NC_001665.2 (2740..3694)

Chromosome MT - NC_001665.2Genomic Context describing neighboring genes Neighboring gene l-rRNA Neighboring gene tRNA-Leu Neighboring gene tRNA-Ile Neighboring gene tRNA-Gln Neighboring gene tRNA-Met

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells. Rafikov R, et al. Redox Biol, 2015 Dec. PMID 26298201, Free PMC Article
  2. Mitochondrial polymorphisms in rat genetic models of hypertension. Kumarasamy S, et al. Mamm Genome, 2010 Jun. PMID 20443117, Free PMC Article
  3. Impaired expression of NADH dehydrogenase subunit 1 and PPARgamma coactivator-1 in skeletal muscle of ZDF rats: restoration by troglitazone. Jové M, et al. J Lipid Res, 2004 Jan. PMID 14563825
  4. Ginkgo biloba extracts EGb 761 and bilobalide increase NADH dehydrogenase mRNA level and mitochondrial respiratory control ratio in PC12 cells. Tendi EA, et al. Neurochem Res, 2002 Apr. PMID 11958534
  5. Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposure. Suliman HB, et al. Free Radic Biol Med, 2002 Feb 1. PMID 11827750

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Electron transport complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells.
    Title: Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

  • Nd1; NADH1

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NADH dehydrogenase (ubiquinone) activity ISO
Inferred from Sequence Orthology
more info
  
enables NADH dehydrogenase (ubiquinone) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
contributes_to NADH dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in aerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, NADH to ubiquinone ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial electron transport, NADH to ubiquinone ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to hydroperoxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NADH dehydrogenase subunit 1
YP_665629.1
  • TAA stop codon is completed by the addition of 3' A residues to the mRNA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001665.2 Reference assembly

    Range
    2740..3694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_665629.1 NADH dehydrogenase subunit 1 (mitochondrion) [Rattus norvegicus]

    See identical proteins and their annotated locations for YP_665629.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O63197, P03889, Q37653
    UniProtKB/TrEMBL
    D2E6L7, H9KVF8, Q8HID1, Q8SEZ8
    Conserved Domains (1) summary
    MTH00104
    Location:1 → 318
    ND1; NADH dehydrogenase subunit 1; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P03889.3

Gene LinkOut

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