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GMEB2 glucocorticoid modulatory element binding protein 2 [ Homo sapiens (human) ]

Gene ID: 26205, updated on 3-Apr-2024

Summary

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Official Symbol
GMEB2provided by HGNC
Official Full Name
glucocorticoid modulatory element binding protein 2provided by HGNC
Primary source
HGNC:HGNC:4371
See related
Ensembl:ENSG00000101216 MIM:607451; AllianceGenome:HGNC:4371
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIF79; GMEB-2; P79PIF
Summary
This gene is a member of KDWK gene family. The product of this gene associates with GMEB1 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. This gene appears to use multiple polyadenylation sites. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 6.7), testis (RPKM 6.1) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See GMEB2 in Genome Data Viewer
Location:
20q13.33
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (63587605..63627101, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (65401053..65440974, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62218958..62258454, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18228 Neighboring gene Sharpr-MPRA regulatory region 13995 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13164 Neighboring gene fibronectin type III domain containing 11 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_61120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18230 Neighboring gene helicase with zinc finger 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18231 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18232 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18233 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:62202570-62202926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13165 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62205701-62206428 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:62207026-62207211 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18234 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62213946-62214446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62214447-62214947 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_61137 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_61148 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_61158 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_61169 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_61181 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_61184 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_61189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18235 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_61197 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62250681-62251180 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_61208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13167 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13168 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_61211 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13169 Neighboring gene melanoma highly expressed competing endogenous lncRNA for miR-425 and miR-489 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18236 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62269990-62270750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13170 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62272271-62273029 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13172 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62273358-62274096 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62275446-62276015 Neighboring gene Sharpr-MPRA regulatory region 12780 Neighboring gene stathmin 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62282910-62283480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13175 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62284757-62285436

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters. Burnett E, et al. J Mol Biol, 2001 Dec 14. PMID 11743720
  2. Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites. Christensen J, et al. Mol Cell Biol, 1999 Nov. PMID 10523663, Free PMC Article
  3. Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins. Kaul S, et al. Mol Endocrinol, 2000 Jul. PMID 10894151
  4. Ubc9 is a novel modulator of the induction properties of glucocorticoid receptors. Kaul S, et al. J Biol Chem, 2002 Apr 12. PMID 11812797
  5. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 1999 Oct 29. PMID 10574462

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters
    Title: A consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1269

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glucocorticoid modulatory element-binding protein 2
Names
DNA-binding protein p79PIF
PIF p79
parvovirus initiation factor, p79

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012384.5 → NP_036516.1  glucocorticoid modulatory element-binding protein 2

    See identical proteins and their annotated locations for NP_036516.1

    Status: REVIEWED

    Source sequence(s)
    AK298927, AL121907, AL353715, AW612659, BC036305
    Consensus CDS
    CCDS13528.1
    UniProtKB/Swiss-Prot
    E1P5J3, Q5TDS0, Q9H431, Q9H4X7, Q9H4X8, Q9UF78, Q9UKD1, Q9ULF1
    UniProtKB/TrEMBL
    Q5JTV1
    Related
    ENSP00000359094.1, ENST00000370077.2
    Conserved Domains (1) summary
    smart00258
    Location:90 → 163
    SAND; SAND domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    63587605..63627101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440106.1 → XP_047296062.1  glucocorticoid modulatory element-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    E1P5J3, Q5TDS0, Q9H431, Q9H4X7, Q9H4X8, Q9UF78, Q9UKD1, Q9ULF1

  2. XM_005260202.5 → XP_005260259.1  glucocorticoid modulatory element-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005260259.1

    UniProtKB/Swiss-Prot
    E1P5J3, Q5TDS0, Q9H431, Q9H4X7, Q9H4X8, Q9UF78, Q9UKD1, Q9ULF1
    UniProtKB/TrEMBL
    Q5JTV1
    Conserved Domains (1) summary
    smart00258
    Location:90 → 163
    SAND; SAND domain

  3. XM_047440105.1 → XP_047296061.1  glucocorticoid modulatory element-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    E1P5J3, Q5TDS0, Q9H431, Q9H4X7, Q9H4X8, Q9UF78, Q9UKD1, Q9ULF1
    Related
    ENSP00000266068.1, ENST00000266068.5

  4. XM_006723776.3 → XP_006723839.1  glucocorticoid modulatory element-binding protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006723839.1

    UniProtKB/TrEMBL
    Q5JTV1
    Related
    ENSP00000359086.1, ENST00000370069.5
    Conserved Domains (1) summary
    smart00258
    Location:12 → 85
    SAND; SAND domain

  5. XM_011528779.3 → XP_011527081.1  glucocorticoid modulatory element-binding protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011527081.1

    UniProtKB/TrEMBL
    Q5JTV1
    Conserved Domains (1) summary
    smart00258
    Location:12 → 85
    SAND; SAND domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    65401053..65440974 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323352.1 → XP_054179327.1  glucocorticoid modulatory element-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    E1P5J3, Q5TDS0, Q9H431, Q9H4X7, Q9H4X8, Q9UF78, Q9UKD1, Q9ULF1

  2. XM_054323353.1 → XP_054179328.1  glucocorticoid modulatory element-binding protein 2 isoform X1

    UniProtKB/Swiss-Prot
    E1P5J3, Q5TDS0, Q9H431, Q9H4X7, Q9H4X8, Q9UF78, Q9UKD1, Q9ULF1

  3. XM_054323354.1 → XP_054179329.1  glucocorticoid modulatory element-binding protein 2 isoform X2

  4. XM_054323355.1 → XP_054179330.1  glucocorticoid modulatory element-binding protein 2 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UKD1.1 GenPept UniProtKB/Swiss-Prot:Q9UKD1

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