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FBXL21P F-box and leucine rich repeat protein 21, pseudogene [ Homo sapiens (human) ]

Gene ID: 26223, updated on 2-Nov-2024

Summary

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Official Symbol
FBXL21Pprovided by HGNC
Official Full Name
F-box and leucine rich repeat protein 21, pseudogeneprovided by HGNC
Primary source
HGNC:HGNC:13600
See related
MIM:609087; AllianceGenome:HGNC:13600
Gene type
pseudo
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBL3B; Fbl21; FBXL21; FBXL3B; FBXL3P
Summary
This locus represents a transcribed pseudogene that is related to genes encoding members of the F-box family of proteins. [provided by RefSeq, Nov 2017]
Annotation information
Annotation category: suggests misassembly
Expression
Biased expression in prostate (RPKM 1.0), adrenal (RPKM 0.7) and 8 other tissues See more
Orthologs
all
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Genomic context

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See FBXL21P in Genome Data Viewer
Location:
5q31.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (135930297..135941996)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (136452800..136464501)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (135265986..135277685)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 48 Neighboring gene uncharacterized LOC107986453 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:135169317-135169818 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:135213247-135213748 Neighboring gene uncharacterized LOC124901074 Neighboring gene interleukin 9 Neighboring gene Sharpr-MPRA regulatory region 2274 Neighboring gene NANOG hESC enhancer GRCh37_chr5:135310975-135311476 Neighboring gene leukocyte cell derived chemotaxin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:135337055-135337556 Neighboring gene uncharacterized LOC105379189

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. FBXL21 association with schizophrenia in Irish family and case-control samples. Chen X, et al. Am J Med Genet B Neuropsychiatr Genet, 2008 Oct 5. PMID 18404645, Free PMC Article
  2. The circadian E3 ligase FBXL21 regulates myoblast differentiation and sarcomere architecture via MYOZ1 ubiquitination and NFAT signaling. Lim JY, et al. PLoS Genet, 2022 Dec. PMID 36574402, Free PMC Article
  3. Ubiquitination of inositol-requiring enzyme 1 (IRE1) by the E3 ligase CHIP mediates the IRE1/TRAF2/JNK pathway. Zhu X, et al. J Biol Chem, 2014 Oct 31. PMID 25225294, Free PMC Article
  4. The GSK-3β-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function. Wirianto M, et al. Cell Rep, 2020 Sep 15. PMID 32937135, Free PMC Article
  5. Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex. Yumimoto K, et al. J Biol Chem, 2013 Nov 8. PMID 24085301, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Using both family and case-control samples, consistent associations in and around FBXL21 gene suggested that FBXL21 may be associated with schizophrenia in the Irish samples.
    Title: FBXL21 association with schizophrenia in Irish family and case-control samples.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: New genetic associations detected in a host response study to hepatitis B vaccine.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Other Names

  • F-box and leucine-rich repeat protein 21
  • F-box and leucine-rich repeat protein 3 pseudogene
  • F-box and leucine-rich repeat protein 3B
  • F-box protein Fbl3b
  • F-box/LRR-repeat protein 21
  • F-box/LRR-repeat protein 3B

Clone Names

  • MGC120237

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in entrainment of circadian clock by photoperiod IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in entrainment of circadian clock by photoperiod ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of ubiquitin ligase complex NAS
Non-traceable Author Statement
more info
 PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_152420.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002428

  2. NR_152421.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002428

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    135930297..135941996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    136452800..136464501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_012159.4: Suppressed sequence

    Description
    NM_012159.4: This RefSeq was removed because it is now thought that this gene is a pseudogene.

  2. NR_132347.1: Suppressed sequence

    Description
    NR_132347.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UKT6.1 GenPept UniProtKB/Swiss-Prot:Q9UKT6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials