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FBXO9 F-box protein 9 [ Homo sapiens (human) ]

Gene ID: 26268, updated on 2-Nov-2024

Summary

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Official Symbol
FBXO9provided by HGNC
Official Full Name
F-box protein 9provided by HGNC
Primary source
HGNC:HGNC:13588
See related
Ensembl:ENSG00000112146 MIM:609091; AllianceGenome:HGNC:13588
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBX9; VCIA1; NY-REN-57; dJ341E18.2
Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 15.5), bone marrow (RPKM 13.7) and 25 other tissues See more
Orthologs
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Genomic context

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See FBXO9 in Genome Data Viewer
Location:
6p12.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (53064998..53100873)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (52904603..52940463)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (52929796..52965671)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17287 Neighboring gene RNA component of 7SK nuclear ribonucleoprotein Neighboring gene ciliogenesis associated kinase 1 Neighboring gene uncharacterized LOC128092246 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:52908870-52909424 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17288 Neighboring gene uncharacterized LOC128031835 Neighboring gene RNA, 7SL, cytoplasmic 244, pseudogene Neighboring gene Sharpr-MPRA regulatory region 2296 Neighboring gene glial cells missing transcription factor 1 Neighboring gene uncharacterized LOC124901513 Neighboring gene RNA, U6 small nuclear 464, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. F-box only protein 9 and its role in cancer. Hussain S, et al. Mol Biol Rep, 2022 Feb. PMID 35025031
  2. Endotoxin stabilizes protein arginine methyltransferase 4 (PRMT4) protein triggering death of lung epithelia. Lai Y, et al. Cell Death Dis, 2021 Sep 3. PMID 34480022, Free PMC Article
  3. The promoter for intestinal cell kinase is head-to-head with F-Box 9 and contains functional sites for TCF7L2 and FOXA factors. Sturgill TW, et al. Mol Cancer, 2010 May 11. PMID 20459822, Free PMC Article
  4. Targeting peroxisome proliferator-activated receptor γ proteasomal degradation by magnolol is a potential avenue for adipogenesis-mediated metabolic homeostasis. Li PL, et al. Obesity (Silver Spring), 2023 Jun. PMID 37203337
  5. SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma. Fernández-Sáiz V, et al. Nat Cell Biol, 2013 Jan. PMID 23263282

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. F-box only protein 9 and its role in cancer.
    Title: F-box only protein 9 and its role in cancer.
  2. ICK and FBX9 are divergently transcribed from a bidirectional promoter that is GC-rich and contains a CpG island.
    Title: The promoter for intestinal cell kinase is head-to-head with F-Box 9 and contains functional sites for TCF7L2 and FOXA factors.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0936, DKFZp434C0118

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-like ligase-substrate adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fat cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of ubiquitin ligase complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
F-box only protein 9
Names
F-box protein Fbx9
cross-immune reaction antigen 1
renal carcinoma antigen NY-REN-57

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012347.4 → NP_036479.1  F-box only protein 9 isoform 1

    See identical proteins and their annotated locations for NP_036479.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is shortest transcript yet it encodes the longest protein (isoform 1).
    Source sequence(s)
    AF176704, AL031178, BC000650
    Consensus CDS
    CCDS55023.1
    UniProtKB/Swiss-Prot
    A6NFW3, B3KMM6, O75986, Q59EH8, Q6PKH7, Q9NT57, Q9UK97, Q9Y593
    Related
    ENSP00000244426.6, ENST00000244426.10
    Conserved Domains (2) summary
    pfam12937
    Location:188 → 239
    F-box-like; F-box-like
    cl00299
    Location:92 → 123
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

  2. NM_033480.3 → NP_258441.1  F-box only protein 9 isoform 2

    See identical proteins and their annotated locations for NP_258441.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a different segment for the 5' UTR and 5' coding region, compared to variant 1. It uses a different translation start codon and the encoded protein (isoform 2) has a shorter and distinct N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AL031178, AL137520
    Consensus CDS
    CCDS55022.1
    UniProtKB/Swiss-Prot
    Q9UK97
    Related
    ENSP00000326968.7, ENST00000323557.12
    Conserved Domains (2) summary
    pfam12937
    Location:178 → 229
    F-box-like; F-box-like
    cl00299
    Location:82 → 113
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

  3. NM_033481.3 → NP_258442.2  F-box only protein 9 isoform 3

    See identical proteins and their annotated locations for NP_258442.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a different segment for the 5' UTR and lacks part of the 5' coding region, compared to variant 1. It uses a downstream translation start codon, with the resulting protein (isoform 3) having a shorter N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AL031178, BC000650
    Consensus CDS
    CCDS55024.1
    Related
    ENSP00000359977.3, ENST00000370939.7
    Conserved Domains (2) summary
    pfam12937
    Location:144 → 190
    F-box-like; F-box-like
    cl00299
    Location:48 → 79
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    53064998..53100873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    52904603..52940463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UK97.1 GenPept UniProtKB/Swiss-Prot:Q9UK97

Gene LinkOut

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