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Ogt O-linked N-acetylglucosamine (GlcNAc) transferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 26295, updated on 14-Nov-2024

Summary

Official Symbol
Ogtprovided by RGD
Official Full Name
O-linked N-acetylglucosamine (GlcNAc) transferaseprovided by RGD
Primary source
RGD:62060
See related
EnsemblRapid:ENSRNOG00000003359 AllianceGenome:RGD:62060
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables several functions, including identical protein binding activity; peptide binding activity; and protein O-acetylglucosaminyltransferase activity. Involved in several processes, including positive regulation of biosynthetic process; regulation of protein localization; and regulation of protein phosphorylation. Located in euchromatin; neuronal cell body; and zymogen granule. Part of protein N-acetylglucosaminyltransferase complex. Is active in several cellular components, including cerebellar granule cell to Purkinje cell synapse; postsynaptic cytosol; and presynaptic cytosol. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 106. Orthologous to human OGT (O-linked N-acetylglucosamine (GlcNAc) transferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 731.3), Spleen (RPKM 610.7) and 9 other tissues See more
Orthologs
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Genomic context

See Ogt in Genome Data Viewer
Location:
Xq22
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (70811317..70856123)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (66771278..66816148)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (71540870..71585906)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA4 Neighboring gene integrin subunit beta 1 binding protein 2 Neighboring gene TATA-box binding protein associated factor 1 Neighboring gene small nucleolar RNA SNORA26 Neighboring gene retinitis pigmentosa 1-like 1 protein-like Neighboring gene ribosomal protein L35A like 4 Neighboring gene C-X-C motif chemokine receptor 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II C-terminal domain S5 O-GlcNAc transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II C-terminal domain S7 O-GlcNAc transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables chromatin DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables peptide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-3,4,5-trisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3,4,5-trisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein O-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein O-acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein O-acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein O-acetylglucosaminyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to toxic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in circadian regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in forebrain development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in glucosamine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glucosamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
involved_in hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular distribution of mitochondria IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in mitophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of non-canonical inflammasome complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of non-canonical inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of non-canonical inflammasome complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of TORC1 signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TORC1 signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of reactive oxygen species biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription from RNA polymerase II promoter by glucose IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription from RNA polymerase II promoter by glucose ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein O-linked glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein O-linked glycosylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein O-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
 
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
 
involved_in protein processing ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of Rac protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of glycolytic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glycolytic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in response to insulin IEA
Inferred from Electronic Annotation
more info
 
involved_in response to insulin ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
part_of NSL complex IEA
Inferred from Electronic Annotation
more info
 
part_of NSL complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cerebellar granule cell to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in euchromatin IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
part_of histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
part_of histone acetyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in postsynaptic cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic cytosol IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein N-acetylglucosaminyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein N-acetylglucosaminyltransferase complex IEA
Inferred from Electronic Annotation
more info
 
part_of protein N-acetylglucosaminyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
 
located_in zymogen granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Names
O linked N-acetylglucosamine transferase
O-GlcNAc transferase subunit p110
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
O-linked N-acetylglucosamine transferase 110 kDa subunit
UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase
NP_001385644.1
NP_058803.2
XP_006257119.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398715.1NP_001385644.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A0G2K3V4, A6IQC5
    Conserved Domains (3) summary
    TIGR02917
    Location:22465
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:327355
    TPR; TPR repeat [structural motif]
    pfam13844
    Location:4761016
    Glyco_transf_41; Glycosyl transferase family 41
  2. NM_017107.3NP_058803.2  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 1

    See identical proteins and their annotated locations for NP_058803.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/Swiss-Prot
    P56558
    UniProtKB/TrEMBL
    A6IQC7, G3V6F4
    Related
    ENSRNOP00000086509.1, ENSRNOT00000100805.2
    Conserved Domains (3) summary
    TIGR02917
    Location:23455
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:317345
    TPR; TPR repeat [structural motif]
    pfam13844
    Location:4661006
    Glyco_transf_41; Glycosyl transferase family 41

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    70811317..70856123
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006257057.5XP_006257119.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1

    See identical proteins and their annotated locations for XP_006257119.1

    UniProtKB/Swiss-Prot
    P56558
    UniProtKB/TrEMBL
    A0A0G2K3V4, A6IQC5
    Related
    ENSRNOP00000004692.6, ENSRNOT00000004692.9
    Conserved Domains (3) summary
    TIGR02917
    Location:22465
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:327355
    TPR; TPR repeat [structural motif]
    pfam13844
    Location:4761016
    Glyco_transf_41; Glycosyl transferase family 41