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Angptl2 angiopoietin-like 2 [ Mus musculus (house mouse) ]

Gene ID: 26360, updated on 2-Nov-2024

Summary

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Official Symbol
Angptl2provided by MGI
Official Full Name
angiopoietin-like 2provided by MGI
Primary source
MGI:MGI:1347002
See related
Ensembl:ENSMUSG00000004105 AllianceGenome:MGI:1347002
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arp2
Summary
Predicted to enable signaling receptor binding activity. Located in extracellular space. Is expressed in several structures, including brain; intraembryonic coelom; limb segment; meninges; and skeleton. Used to study dermatomyositis. Orthologous to human ANGPTL2 (angiopoietin like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in mammary gland adult (RPKM 99.1), subcutaneous fat pad adult (RPKM 61.8) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Angptl2 in Genome Data Viewer
Location:
2 B; 2 22.36 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (33105963..33137737)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (33215951..33247725)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Ral GEF with PH domain and SH3 binding motif 1 Neighboring gene predicted gene 13528 Neighboring gene predicted gene, 23546 Neighboring gene STARR-seq mESC enhancer starr_04235 Neighboring gene zinc finger and BTB domain containing 34 Neighboring gene STARR-seq mESC enhancer starr_04237 Neighboring gene STARR-seq mESC enhancer starr_04239 Neighboring gene predicted gene 13536 Neighboring gene zinc finger and BTB domain containing 43

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ANGPTL2 promotes immune checkpoint inhibitor-related murine autoimmune myocarditis. Horiguchi H, et al. Commun Biol, 2023 Sep 22. PMID 37736764, Free PMC Article
  2. Angiopoietin-like protein 2 mediates endotoxin-induced acute inflammation in the eye. Kanda A, et al. Lab Invest, 2012 Nov. PMID 22868908
  3. Angiopoietin-like protein 2 is a potent hemangiogenic and lymphangiogenic factor in corneal inflammation. Toyono T, et al. Invest Ophthalmol Vis Sci, 2013 Jun 26. PMID 23702783
  4. Angiopoietin-like protein 2 is an important facilitator of inflammatory carcinogenesis and metastasis. Aoi J, et al. Cancer Res, 2011 Dec 15. PMID 22042794
  5. ANGPTL2 promotes tumor metastasis in hepatocellular carcinoma. Gao L, et al. J Gastroenterol Hepatol, 2015 Feb. PMID 25090954

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ANGPTL2 knockdown induces autophagy to relieve alveolar macrophage pyroptosis by reducing LILRB2-mediated inhibition of TREM2.
    Title: ANGPTL2 knockdown induces autophagy to relieve alveolar macrophage pyroptosis by reducing LILRB2-mediated inhibition of TREM2.
  2. ANGPTL2-mediated epigenetic repression of MHC-I in tumor cells accelerates tumor immune evasion.
    Title: ANGPTL2-mediated epigenetic repression of MHC-I in tumor cells accelerates tumor immune evasion.
  3. ANGPTL2 promotes immune checkpoint inhibitor-related murine autoimmune myocarditis.
    Title: ANGPTL2 promotes immune checkpoint inhibitor-related murine autoimmune myocarditis.
  4. ANGPTL2 aggravates LPS-induced septic cardiomyopathy via NLRP3-mediated inflammasome in a DUSP1-dependent pathway.
    Title: ANGPTL2 aggravates LPS-induced septic cardiomyopathy via NLRP3-mediated inflammasome in a DUSP1-dependent pathway.
  5. ANGPTL2 Deletion Attenuates Neuroinflammation and Cognitive Dysfunction Induced by Isoflurane in Aged Mice through Modulating MAPK Pathway.
    Title: ANGPTL2 Deletion Attenuates Neuroinflammation and Cognitive Dysfunction Induced by Isoflurane in Aged Mice through Modulating MAPK Pathway.
  6. Angiopoietin-like 2 is essential to aortic valve development in mice.
    Title: Angiopoietin-like 2 is essential to aortic valve development in mice.
  7. Tumor cell-derived ANGPTL2 promotes beta-catenin-driven intestinal tumorigenesis.
    Title: Tumor cell-derived ANGPTL2 promotes β-catenin-driven intestinal tumorigenesis.
  8. Efficient expansion of mouse hematopoietic stem cells ex vivo by membrane anchored Angptl2.
    Title: Efficient expansion of mouse hematopoietic stem cells ex vivo by membrane anchored Angptl2.
  9. Endothelial cell-derived angiopoietin-like protein 2 supports hematopoietic stem cell activities in bone marrow niches.
    Title: Endothelial cell-derived angiopoietin-like protein 2 supports hematopoietic stem cell activities in bone marrow niches.
  10. ANGPTL2 Promotes Inflammation via Integrin alpha5beta1 in Chondrocytes.
    Title: ANGPTL2 Promotes Inflammation via Integrin α5β1 in Chondrocytes.
Submit: New GeneRIF Correction See all GeneRIFs (46)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
angiopoietin-related protein 2
Names
angiopoietin-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011923.4 → NP_036053.2  angiopoietin-related protein 2 precursor

    See identical proteins and their annotated locations for NP_036053.2

    Status: PROVISIONAL

    Source sequence(s)
    AK155464
    Consensus CDS
    CCDS15940.1
    UniProtKB/Swiss-Prot
    Q8BM09, Q9R045
    Related
    ENSMUSP00000004208.6, ENSMUST00000004208.7
    Conserved Domains (2) summary
    smart00397
    Location:156 → 206
    t_SNARE; Helical region found in SNAREs
    cd00087
    Location:273 → 487
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    33105963..33137737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498051.1 → XP_006498114.1  angiopoietin-related protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006498114.1

    UniProtKB/Swiss-Prot
    Q8BM09, Q9R045
    Conserved Domains (2) summary
    smart00397
    Location:156 → 206
    t_SNARE; Helical region found in SNAREs
    cd00087
    Location:273 → 487
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R045.2 GenPept UniProtKB/Swiss-Prot:Q9R045

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