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Pkn3 protein kinase N3 [ Mus musculus (house mouse) ]

Gene ID: 263803, updated on 2-Nov-2024

Summary

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Official Symbol
Pkn3provided by MGI
Official Full Name
protein kinase N3provided by MGI
Primary source
MGI:MGI:2388285
See related
Ensembl:ENSMUSG00000026785 AllianceGenome:MGI:2388285
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in epithelial cell migration and intracellular signal transduction. Predicted to be located in nucleus and perinuclear region of cytoplasm. Is expressed in several structures, including genitourinary system; heart; respiratory system; submandibular gland; and vascular system. Orthologous to human PKN3 (protein kinase N3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lung adult (RPKM 8.5), subcutaneous fat pad adult (RPKM 6.3) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Pkn3 in Genome Data Viewer
Location:
2 B; 2 21.13 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (29967657..29981031)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30077548..30091023)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene dynein 2 intermediate chain 2 Neighboring gene STARR-seq mESC enhancer starr_04082 Neighboring gene STARR-positive B cell enhancer ABC_E4426 Neighboring gene SET nuclear oncogene Neighboring gene STARR-positive B cell enhancer ABC_E8783 Neighboring gene STARR-positive B cell enhancer ABC_E3366 Neighboring gene zinc finger, DHHC domain containing 12 Neighboring gene zyg-11 related, cell cycle regulator Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:29979764-29979873 Neighboring gene STARR-seq mESC enhancer starr_04088 Neighboring gene STARR-positive B cell enhancer ABC_E4427 Neighboring gene TBC1 domain family, member 13 Neighboring gene reactive oxygen species modulator 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PKN3 is the major regulator of angiogenesis and tumor metastasis in mice. Mukai H, et al. Sci Rep, 2016 Jan 8. PMID 26742562, Free PMC Article
  2. The interaction of PKN3 with RhoC promotes malignant growth. Unsal-Kacmaz K, et al. Mol Oncol, 2012 Jun. PMID 22217540, Free PMC Article
  3. PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase. Leenders F, et al. EMBO J, 2004 Aug 18. PMID 15282551, Free PMC Article
  4. Protein kinase N3 promotes bone resorption by osteoclasts in response to Wnt5a-Ror2 signaling. Uehara S, et al. Sci Signal, 2017 Aug 29. PMID 28851822
  5. The interaction of p130Cas with PKN3 promotes malignant growth. Gemperle J, et al. Mol Oncol, 2019 Feb. PMID 30422386, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a novel interaction of p130Cas with Ser/Thr kinase PKN3, is reported.
    Title: The interaction of p130Cas with PKN3 promotes malignant growth.
  2. Pkn3 promotes bone resorption downstream of Wnt5a-Ror2-Rho signaling, and this pathway may be a therapeutic target for bone diseases such as osteoporosis, rheumatoid arthritis, and periodontal disease.
    Title: Protein kinase N3 promotes bone resorption by osteoclasts in response to Wnt5a-Ror2 signaling.
  3. PKN3 is the major regulator of angiogenesis in humans and mice and tumor metastasis in mice.
    Title: PKN3 is the major regulator of angiogenesis and tumor metastasis in mice.
  4. Data demonstrate that PKN3 physically interacts with Rho-family GTPases, and preferentially with RhoC, a known mediator of tumor invasion and metastasis in epithelial cancers.
    Title: The interaction of PKN3 with RhoC promotes malignant growth.
  5. PKN3 might represent a preferred target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of phosphoinositide 3-kinase
    Title: PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (6)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC31699

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in epithelial cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase N3
Names
protein kinase PKN-beta
protein kinase PKNbeta
protein-kinase C-related kinase 3
NP_722500.1
XP_006498115.1
XP_006498116.1
XP_006498117.1
XP_030107417.1
XP_030107418.1
XP_030107419.1
XP_030107420.1
XP_030107421.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153805.2 → NP_722500.1  serine/threonine-protein kinase N3

    See identical proteins and their annotated locations for NP_722500.1

    Status: VALIDATED

    Source sequence(s)
    BX005298
    Consensus CDS
    CCDS15867.1
    UniProtKB/Swiss-Prot
    Q8K045
    Related
    ENSMUSP00000041025.8, ENSMUST00000045246.8
    Conserved Domains (5) summary
    PTZ00263
    Location:544 → 868
    PTZ00263; protein kinase A catalytic subunit; Provisional
    cd11622
    Location:10 → 75
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd05589
    Location:548 → 873
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:90 → 163
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl14603
    Location:321 → 408
    C2; C2 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    29967657..29981031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251558.2 → XP_030107418.1  serine/threonine-protein kinase N3 isoform X2

    Conserved Domains (4) summary
    cd11622
    Location:14 → 79
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd05589
    Location:575 → 900
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:94 → 167
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl14603
    Location:348 → 435
    C2; C2 domain

  2. XM_006498053.5 → XP_006498116.1  serine/threonine-protein kinase N3 isoform X6

    See identical proteins and their annotated locations for XP_006498116.1

    Conserved Domains (4) summary
    cd11622
    Location:14 → 79
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd05589
    Location:552 → 877
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:94 → 167
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl14603
    Location:325 → 412
    C2; C2 domain

  3. XM_030251559.2 → XP_030107419.1  serine/threonine-protein kinase N3 isoform X3

    Conserved Domains (4) summary
    cd11622
    Location:13 → 78
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd05589
    Location:574 → 899
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:93 → 166
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl14603
    Location:347 → 434
    C2; C2 domain

  4. XM_030251561.2 → XP_030107421.1  serine/threonine-protein kinase N3 isoform X8

    Conserved Domains (5) summary
    cd11622
    Location:23 → 88
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    PRK14950
    Location:477 → 579
    PRK14950; DNA polymerase III subunits gamma and tau; Provisional
    cl00087
    Location:103 → 176
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl14603
    Location:357 → 444
    C2; C2 domain
    cl21453
    Location:584 → 600
    PKc_like; Protein Kinases, catalytic domain

  5. XM_030251557.2 → XP_030107417.1  serine/threonine-protein kinase N3 isoform X1

    Conserved Domains (4) summary
    cd11622
    Location:23 → 88
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd05589
    Location:584 → 909
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:103 → 176
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl14603
    Location:357 → 444
    C2; C2 domain

  6. XM_006498052.5 → XP_006498115.1  serine/threonine-protein kinase N3 isoform X5

    Conserved Domains (4) summary
    cd11622
    Location:23 → 88
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd05589
    Location:561 → 886
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:103 → 176
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl14603
    Location:334 → 421
    C2; C2 domain

  7. XM_030251560.2 → XP_030107420.1  serine/threonine-protein kinase N3 isoform X4

    Conserved Domains (4) summary
    cd11622
    Location:10 → 75
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd05589
    Location:571 → 896
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:90 → 163
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl14603
    Location:344 → 431
    C2; C2 domain

  8. XM_006498054.4 → XP_006498117.1  serine/threonine-protein kinase N3 isoform X7

    See identical proteins and their annotated locations for XP_006498117.1

    UniProtKB/TrEMBL
    Q3UQS3
    Related
    ENSMUST00000137240.8
    Conserved Domains (3) summary
    cd05589
    Location:426 → 751
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:41 → 99
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl14603
    Location:199 → 286
    C2; C2 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K045.1 GenPept UniProtKB/Swiss-Prot:Q8K045

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