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Esrrg estrogen-related receptor gamma [ Mus musculus (house mouse) ]

Gene ID: 26381, updated on 28-Oct-2024

Summary

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Official Symbol
Esrrgprovided by MGI
Official Full Name
estrogen-related receptor gammaprovided by MGI
Primary source
MGI:MGI:1347056
See related
Ensembl:ENSMUSG00000026610 AllianceGenome:MGI:1347056
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ERR3; Errg; NR3B3; mKIAA0832
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and estrogen response element binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and sensory organ. Orthologous to human ESRRG (estrogen related receptor gamma). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in cerebellum adult (RPKM 6.9), kidney adult (RPKM 4.9) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Esrrg in Genome Data Viewer
Location:
1 H5- H6; 1 91.83 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (187340707..187947082)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (187608510..188214885)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36249 Neighboring gene predicted gene, 36388 Neighboring gene predicted gene, 46176 Neighboring gene predicted gene, 53517 Neighboring gene STARR-seq mESC enhancer starr_03371 Neighboring gene VISTA enhancer mm111 Neighboring gene STARR-seq mESC enhancer starr_03373 Neighboring gene RIKEN cDNA 9330162B11 gene Neighboring gene STARR-seq mESC enhancer starr_03374 Neighboring gene predicted gene, 51738 Neighboring gene usherin Neighboring gene STARR-seq mESC enhancer starr_03375 Neighboring gene STARR-seq mESC enhancer starr_03376 Neighboring gene predicted gene, 39735 Neighboring gene predicted gene, 36456

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivity. Greschik H, et al. J Biol Chem, 2004 Aug 6. PMID 15161930
  2. Estrogen receptor-related receptor γ regulates testicular steroidogenesis through direct and indirect regulation of steroidogenic gene expression. Park E, et al. Mol Cell Endocrinol, 2017 Sep 5. PMID 28479375
  3. Androgen-Dependent Repression of ERRγ Reprograms Metabolism in Prostate Cancer. Audet-Walsh É, et al. Cancer Res, 2017 Jan 15. PMID 27821488
  4. ERRγ Preserves Brown Fat Innate Thermogenic Activity. Ahmadian M, et al. Cell Rep, 2018 Mar 13. PMID 29539415, Free PMC Article
  5. O-GlcNAcylation of Orphan Nuclear Receptor Estrogen-Related Receptor γ Promotes Hepatic Gluconeogenesis. Misra J, et al. Diabetes, 2016 Oct. PMID 27335230

See all (136) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ESRRG-controlled downregulation of KCNN1 in primary sensory neurons is required for neuropathic pain.
    Title: ESRRG-controlled downregulation of KCNN1 in primary sensory neurons is required for neuropathic pain.
  2. Upregulation of the ERRgamma-VDAC1 axis underlies the molecular pathogenesis of pancreatitis.
    Title: Upregulation of the ERRγ-VDAC1 axis underlies the molecular pathogenesis of pancreatitis.
  3. Estrogen-related receptor gamma (ERRgamma) is a key regulator of lysyl oxidase gene expression in mouse hepatocytes.
    Title: Estrogen-related receptor γ (ERRγ) is a key regulator of lysyl oxidase gene expression in mouse hepatocytes.
  4. ERR2 and ERR3 promote the development of gamma motor neuron functional properties required for proprioceptive movement control.
    Title: ERR2 and ERR3 promote the development of gamma motor neuron functional properties required for proprioceptive movement control.
  5. Lupus susceptibility gene Esrrg modulates regulatory T cells through mitochondrial metabolism.
    Title: Lupus susceptibility gene Esrrg modulates regulatory T cells through mitochondrial metabolism.
  6. Orphan nuclear receptor ERRgamma regulates hepatic TGF-beta2 expression and fibrogenic response in CCl4-induced acute liver injury.
    Title: Orphan nuclear receptor ERRγ regulates hepatic TGF-β2 expression and fibrogenic response in CCl(4)-induced acute liver injury.
  7. Orphan nuclear receptor ERR-gamma regulates hepatic FGF23 production in acute kidney injury.
    Title: Orphan nuclear receptor ERR-γ regulates hepatic FGF23 production in acute kidney injury.
  8. Cardiac-Specific Overexpression of ERRgamma in Mice Induces Severe Heart Dysfunction and Early Lethality.
    Title: Cardiac-Specific Overexpression of ERRγ in Mice Induces Severe Heart Dysfunction and Early Lethality.
  9. A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation.
    Title: A Critical Role for Estrogen-Related Receptor Signaling in Cardiac Maturation.
  10. ERRgamma suppression by Sirt6 alleviates cholestatic liver injury and fibrosis.
    Title: ERRγ suppression by Sirt6 alleviates cholestatic liver injury and fibrosis.
Submit: New GeneRIF Correction See all GeneRIFs (64)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (7)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables estrogen response element binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables estrogen response element binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables nuclear steroid receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables steroid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nuclear receptor-mediated steroid hormone signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retinoic acid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in steroid hormone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
estrogen-related receptor gamma
Names
estrogen receptor-related protein 3
estrogen-related receptor 3
nuclear receptor subfamily 3 group B member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243792.1 → NP_001230721.1  estrogen-related receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_001230721.1

    Status: VALIDATED

    Source sequence(s)
    AK052731, BC082324, BY067844
    Consensus CDS
    CCDS56666.1
    UniProtKB/Swiss-Prot
    P62509
    Related
    ENSMUSP00000106564.2, ENSMUST00000110939.8
    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  2. NM_001357534.1 → NP_001344463.1  estrogen-related receptor gamma isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109296, AC115061, AC116380, AC122122
    Consensus CDS
    CCDS56666.1
    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  3. NM_001357535.1 → NP_001344464.1  estrogen-related receptor gamma isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109296, AC115061, AC116380, AC122122
    Consensus CDS
    CCDS56666.1
    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  4. NM_001357536.1 → NP_001344465.1  estrogen-related receptor gamma isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC116380, AC122122
    Conserved Domains (2) summary
    cd06946
    Location:220 → 439
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:105 → 201
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  5. NM_011935.3 → NP_036065.1  estrogen-related receptor gamma isoform1

    See identical proteins and their annotated locations for NP_036065.1

    Status: VALIDATED

    Source sequence(s)
    BC082324, CJ062694
    Consensus CDS
    CCDS15606.1
    UniProtKB/Swiss-Prot
    P62509, Q8CHC9
    Related
    ENSMUSP00000027906.7, ENSMUST00000027906.13
    Conserved Domains (2) summary
    cd06946
    Location:237 → 456
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:122 → 218
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    187340707..187947082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238916.4 → XP_011237218.1  estrogen-related receptor gamma isoform X1

    See identical proteins and their annotated locations for XP_011237218.1

    Conserved Domains (2) summary
    cd06946
    Location:226 → 445
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:111 → 207
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  2. XM_006497165.5 → XP_006497228.1  estrogen-related receptor gamma isoform X3

    See identical proteins and their annotated locations for XP_006497228.1

    UniProtKB/Swiss-Prot
    P62509
    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  3. XM_036165240.1 → XP_036021133.1  estrogen-related receptor gamma isoform X3

    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  4. XM_011238917.4 → XP_011237219.1  estrogen-related receptor gamma isoform X1

    See identical proteins and their annotated locations for XP_011237219.1

    Conserved Domains (2) summary
    cd06946
    Location:226 → 445
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:111 → 207
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  5. XM_011238920.4 → XP_011237222.1  estrogen-related receptor gamma isoform X1

    See identical proteins and their annotated locations for XP_011237222.1

    Conserved Domains (2) summary
    cd06946
    Location:226 → 445
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:111 → 207
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  6. XM_011238918.4 → XP_011237220.1  estrogen-related receptor gamma isoform X1

    See identical proteins and their annotated locations for XP_011237220.1

    Conserved Domains (2) summary
    cd06946
    Location:226 → 445
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:111 → 207
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  7. XM_011238915.4 → XP_011237217.1  estrogen-related receptor gamma isoform X1

    See identical proteins and their annotated locations for XP_011237217.1

    Conserved Domains (2) summary
    cd06946
    Location:226 → 445
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:111 → 207
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  8. XM_030254422.2 → XP_030110282.1  estrogen-related receptor gamma isoform X1

    Conserved Domains (2) summary
    cd06946
    Location:226 → 445
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:111 → 207
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  9. XM_036165247.1 → XP_036021140.1  estrogen-related receptor gamma isoform X3

    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  10. XM_011238919.4 → XP_011237221.1  estrogen-related receptor gamma isoform X1

    See identical proteins and their annotated locations for XP_011237221.1

    Conserved Domains (2) summary
    cd06946
    Location:226 → 445
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:111 → 207
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  11. XM_036165239.1 → XP_036021132.1  estrogen-related receptor gamma isoform X3

    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  12. XM_036165237.1 → XP_036021130.1  estrogen-related receptor gamma isoform X1

    Conserved Domains (2) summary
    cd06946
    Location:226 → 445
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:111 → 207
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  13. XM_036165242.1 → XP_036021135.1  estrogen-related receptor gamma isoform X3

    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  14. XM_036165250.1 → XP_036021143.1  estrogen-related receptor gamma isoform X3

    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  15. XM_006497170.3 → XP_006497233.1  estrogen-related receptor gamma isoform X3

    See identical proteins and their annotated locations for XP_006497233.1

    UniProtKB/Swiss-Prot
    P62509
    Related
    ENSMUSP00000106563.2, ENSMUST00000110938.2
    Conserved Domains (2) summary
    cd06946
    Location:214 → 433
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:99 → 195
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

  16. XM_030254424.2 → XP_030110284.1  estrogen-related receptor gamma isoform X2

    Conserved Domains (2) summary
    cd06946
    Location:224 → 443
    NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    cd07170
    Location:109 → 205
    NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62509.1 GenPept UniProtKB/Swiss-Prot:P62509

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