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Lypla2 lysophospholipase 2 [ Mus musculus (house mouse) ]

Gene ID: 26394, updated on 2-Nov-2024

Summary

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Official Symbol
Lypla2provided by MGI
Official Full Name
lysophospholipase 2provided by MGI
Primary source
MGI:MGI:1347000
See related
Ensembl:ENSMUSG00000028670 AllianceGenome:MGI:1347000
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LysoII
Summary
Enables palmitoyl-(protein) hydrolase activity. Involved in prostaglandin catabolic process and protein depalmitoylation. Located in Golgi stack. Is expressed in several structures, including alimentary system; eye; integumental system; nervous system; and urinary system. Orthologous to human LYPLA2 (lysophospholipase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in colon adult (RPKM 103.7), duodenum adult (RPKM 82.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Lypla2 in Genome Data Viewer
Location:
4 D3; 4 68.33 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135695541..135700954, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135968224..135972612, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene 3-hydroxy-3-methylglutaryl-Coenzyme A lyase Neighboring gene STARR-positive B cell enhancer ABC_E4686 Neighboring gene STARR-positive B cell enhancer ABC_E3529 Neighboring gene galactose-4-epimerase, UDP Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135528566-135528675 Neighboring gene PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1 Neighboring gene predicted gene 13007

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria. Speck SL, et al. Cell Rep, 2023 Nov 28. PMID 37925639, Free PMC Article
  2. Sequence, expression in Escherichia coli, and characterization of lysophospholipase II. Toyoda T, et al. Biochim Biophys Acta, 1999 Feb 25. PMID 10064901
  3. Prediction of human cDNA from its homologous mouse full-length cDNA and human shotgun database. Fukunishi Y, et al. FEBS Lett, 1999 Dec 31. PMID 10618491
  4. Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells. Manna JD, et al. J Biol Chem, 2014 Dec 5. PMID 25301951, Free PMC Article
  5. Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle. Won SJ, et al. ACS Chem Biol, 2018 Jun 15. PMID 29733200, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that thioesterases APT1/APT2 depalmitoylate nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) and zDHHC17 is the strongest candidate palmitoyltransferase for NMNAT2.
    Title: Identification of palmitoyltransferase and thioesterase enzymes that control the subcellular localization of axon survival factor nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2).
  2. Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43
    Title: Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysophospholipase activity ISO
Inferred from Sequence Orthology
more info
  
enables lysophospholipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables palmitoyl-(protein) hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables palmitoyl-(protein) hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables palmitoyl-(protein) hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acylglycerol catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in acylglycerol catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in prostaglandin catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in prostaglandin catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein depalmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein depalmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein depalmitoylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi stack IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
acyl-protein thioesterase 2
Names
APT-2
LPL-II
lysoPLA II
lysophospholipase II
mLyso II
palmitoyl-protein hydrolase
NP_001405973.1
NP_001405974.1
NP_001405975.1
NP_036072.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419044.1 → NP_001405973.1  acyl-protein thioesterase 2

    Status: VALIDATED

    Source sequence(s)
    AL672076
    UniProtKB/Swiss-Prot
    Q3TJD6, Q9WTL7

  2. NM_001419045.1 → NP_001405974.1  acyl-protein thioesterase 2

    Status: VALIDATED

    Source sequence(s)
    AL672076
    UniProtKB/Swiss-Prot
    Q3TJD6, Q9WTL7
    Related
    ENSMUSP00000101478.2, ENSMUST00000105852.8

  3. NM_001419046.1 → NP_001405975.1  acyl-protein thioesterase 2

    Status: VALIDATED

    Source sequence(s)
    AL672076
    UniProtKB/Swiss-Prot
    Q3TJD6, Q9WTL7

  4. NM_011942.2 → NP_036072.1  acyl-protein thioesterase 2

    See identical proteins and their annotated locations for NP_036072.1

    Status: VALIDATED

    Source sequence(s)
    AL672076
    Consensus CDS
    CCDS18797.1
    UniProtKB/Swiss-Prot
    Q3TJD6, Q9WTL7
    Related
    ENSMUSP00000064204.5, ENSMUST00000067567.5
    Conserved Domains (1) summary
    pfam02230
    Location:14 → 228
    Abhydrolase_2; Phospholipase/Carboxylesterase

RNA

  1. NR_185005.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL672076

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    135695541..135700954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WTL7.1 GenPept UniProtKB/Swiss-Prot:Q9WTL7

Gene LinkOut

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