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Map3k8 mitogen-activated protein kinase kinase kinase 8 [ Mus musculus (house mouse) ]

Gene ID: 26410, updated on 2-Nov-2024

Summary

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Official Symbol
Map3k8provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase 8provided by MGI
Primary source
MGI:MGI:1346878
See related
Ensembl:ENSMUSG00000024235 AllianceGenome:MGI:1346878
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cot; Est; Estf; Tpl2; Tpl-2; c-COT; Cot/Tpl2
Summary
Predicted to enable MAP kinase kinase kinase activity. Predicted to be involved in MAPK cascade and gap junction-mediated intercellular transport. Predicted to be located in cytosol. Is expressed in several structures, including adipose tissue; adrenal gland; alimentary system; hemolymphoid system gland; and reproductive system. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma; lung cancer; and stomach cancer. Orthologous to human MAP3K8 (mitogen-activated protein kinase kinase kinase 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in spleen adult (RPKM 3.1), lung adult (RPKM 2.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Map3k8 in Genome Data Viewer
Location:
18 A1; 18 2.73 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (4331325..4352978, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (4331325..4352953, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43673 Neighboring gene predicted gene, 41657 Neighboring gene STARR-seq mESC enhancer starr_43674 Neighboring gene STARR-positive B cell enhancer ABC_E7569 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:4295908-4296095 Neighboring gene carbohydrate sulfotransferase 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43675 Neighboring gene RIKEN cDNA 4833419F23 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:4375540-4375727 Neighboring gene mitochondrial poly(A) polymerase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic and pharmacological targeting of TPL-2 kinase ameliorates experimental colitis: a potential target for the treatment of Crohn's disease? Lawrenz M, et al. Mucosal Immunol, 2012 Mar. PMID 22157885
  2. Map3k8 controls granulocyte colony-stimulating factor production and neutrophil precursor proliferation in lipopolysaccharide-induced emergency granulopoiesis. Sánchez Á, et al. Sci Rep, 2017 Jul 10. PMID 28694430, Free PMC Article
  3. Tpl2 promotes neutrophil trafficking, oxidative burst, and bacterial killing. Acuff NV, et al. J Leukoc Biol, 2017 Jun. PMID 28356348, Free PMC Article
  4. Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production. Mielke LA, et al. J Immunol, 2009 Dec 15. PMID 19933865, Free PMC Article
  5. Ablation of tumor progression locus 2 promotes a type 2 Th cell response in Ovalbumin-immunized mice. Watford WT, et al. J Immunol, 2010 Jan 1. PMID 19955521, Free PMC Article

See all (143) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice.
    Title: TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice.
  2. Tumor Progression Locus 2 Protects against Acute Respiratory Distress Syndrome in Influenza A Virus-Infected Mice.
    Title: Tumor Progression Locus 2 Protects against Acute Respiratory Distress Syndrome in Influenza A Virus-Infected Mice.
  3. Loss of Tpl2 activates compensatory signaling and resistance to EGFR/MET dual inhibition in v-RAS transduced keratinocytes.
    Title: Loss of Tpl2 activates compensatory signaling and resistance to EGFR/MET dual inhibition in v-RAS transduced keratinocytes.
  4. TPL-2 Inhibits IFN-beta Expression via an ERK1/2-TCF-FOS Axis in TLR4-Stimulated Macrophages.
    Title: TPL-2 Inhibits IFN-β Expression via an ERK1/2-TCF-FOS Axis in TLR4-Stimulated Macrophages.
  5. Influenza-induced Tpl2 expression within alveolar epithelial cells is dispensable for host viral control and anti-viral immunity.
    Title: Influenza-induced Tpl2 expression within alveolar epithelial cells is dispensable for host viral control and anti-viral immunity.
  6. Tpl2 Ablation Leads to Hypercytokinemia and Excessive Cellular Infiltration to the Lungs During Late Stages of Influenza Infection.
    Title: Tpl2 Ablation Leads to Hypercytokinemia and Excessive Cellular Infiltration to the Lungs During Late Stages of Influenza Infection.
  7. Toll-Like Receptor 2-Tpl2-Dependent ERK Signaling Drives Inverse Interleukin 12 Regulation in Dendritic Cells and Macrophages.
    Title: Toll-Like Receptor 2-Tpl2-Dependent ERK Signaling Drives Inverse Interleukin 12 Regulation in Dendritic Cells and Macrophages.
  8. Tpl2 kinase regulates inflammation but not tumorigenesis in mice.
    Title: Tpl2 kinase regulates inflammation but not tumorigenesis in mice.
  9. Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells.
    Title: Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells.
  10. promotes both liver and systemic metabolic disturbances by specifically increasing MKK7-JNK activation
    Title: Tumor Progression Locus 2 in Hepatocytes Potentiates Both Liver and Systemic Metabolic Disorders in Mice.
Submit: New GeneRIF Correction See all GeneRIFs (86)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in gap junction-mediated intercellular transport ISO
Inferred from Sequence Orthology
more info
  
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 8
Names
COT proto-oncogene serine/threonine-protein kinase
cancer Osaka thyroid oncogene
proto-oncogene c-Cot
serine/threonine-protein kinase cot
tumor progression locus 2
NP_031772.1
XP_006526007.1
XP_036017050.1
XP_036017051.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007746.2 → NP_031772.1  mitogen-activated protein kinase kinase kinase 8

    See identical proteins and their annotated locations for NP_031772.1

    Status: VALIDATED

    Source sequence(s)
    AC138768
    Consensus CDS
    CCDS29036.1
    UniProtKB/Swiss-Prot
    Q07174
    UniProtKB/TrEMBL
    Q3U086, Q3UEB8
    Related
    ENSMUSP00000025078.3, ENSMUST00000025078.10
    Conserved Domains (2) summary
    smart00220
    Location:146 → 386
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13995
    Location:133 → 388
    STKc_MAP3K8; Catalytic domain of the Serine/Threonine kinase, Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase 8

RNA

  1. NR_157375.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK140334, AK171403
    Related
    ENSMUST00000173930.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    4331325..4352978 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161157.1 → XP_036017050.1  mitogen-activated protein kinase kinase kinase 8 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:80 → 211
    PKc_like; Protein Kinases, catalytic domain

  2. XM_006525944.3 → XP_006526007.1  mitogen-activated protein kinase kinase kinase 8 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:2 → 231
    PKc_like; Protein Kinases, catalytic domain

  3. XM_036161158.1 → XP_036017051.1  mitogen-activated protein kinase kinase kinase 8 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:65 → 196
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_003952522.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07174.1 GenPept UniProtKB/Swiss-Prot:Q07174

Gene LinkOut

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