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Nubp2 nucleotide binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 26426, updated on 28-Oct-2024

Summary

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Official Symbol
Nubp2provided by MGI
Official Full Name
nucleotide binding protein 2provided by MGI
Primary source
MGI:MGI:1347072
See related
Ensembl:ENSMUSG00000039183 AllianceGenome:MGI:1347072
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D17Wsu11e
Summary
Predicted to enable iron-sulfur cluster binding activity. Predicted to be involved in iron-sulfur cluster assembly. Located in nucleus and spindle pole centrosome. Is expressed in several structures, including extraembryonic component; genitourinary system; liver; lung; and spleen. Orthologous to human NUBP2 (NUBP iron-sulfur cluster assembly factor 2, cytosolic). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in testis adult (RPKM 44.5), thymus adult (RPKM 22.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nubp2 in Genome Data Viewer
Location:
17 A3.3; 17 12.53 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25101585..25105423, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24882611..24886350, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene hydroxyacyl glutathione hydrolase Neighboring gene STARR-positive B cell enhancer ABC_E486 Neighboring gene fumarylacetoacetate hydrolase domain containing 1 Neighboring gene predicted gene, 41549 Neighboring gene STARR-seq mESC enhancer starr_42099 Neighboring gene STARR-seq mESC enhancer starr_42100 Neighboring gene insulin-like growth factor binding protein, acid labile subunit Neighboring gene STARR-positive B cell enhancer ABC_E216 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 3 Neighboring gene essential meiotic structure-specific endonuclease subunit 2 Neighboring gene mitochondrial ribosomal protein S34

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Random monoallelic expression of three genes clustered within 60 kb of mouse t complex genomic DNA. Sano Y, et al. Genome Res, 2001 Nov. PMID 11691847, Free PMC Article
  2. Comparison of intracellular localization of Nubp1 and Nubp2 using GFP fusion proteins. Okuno T, et al. Mol Biol Rep, 2010 Mar. PMID 19263241
  3. A novel family of katanin-like 2 protein isoforms (KATNAL2), interacting with nucleotide-binding proteins Nubp1 and Nubp2, are key regulators of different MT-based processes in mammalian cells. Ververis A, et al. Cell Mol Life Sci, 2016 Jan. PMID 26153462, Free PMC Article
  4. The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis. Kypri E, et al. Cell Mol Life Sci, 2014 Feb. PMID 23807208, Free PMC Article
  5. Motor protein KIFC5A interacts with Nubp1 and Nubp2, and is implicated in the regulation of centrosome duplication. Christodoulou A, et al. J Cell Sci, 2006 May 15. PMID 16638812

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nubp2 is required for cranial neural crest survival in the mouse.
    Title: Nubp2 is required for cranial neural crest survival in the mouse.
  2. KATNAL2 isoforms interact with themselves, with each other and with Nubp1 and Nubp2.
    Title: A novel family of katanin-like 2 protein isoforms (KATNAL2), interacting with nucleotide-binding proteins Nubp1 and Nubp2, are key regulators of different MT-based processes in mammalian cells.
  3. The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis.
    Title: The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis.
  4. Both termini of Nubp2 contribute to nuclear transfer of Nubp2 and morphology of the nucleus.
    Title: Comparison of intracellular localization of Nubp1 and Nubp2 using GFP fusion proteins.
  5. KIFC5A interacts with nucleotide-binding proteins 1 and 2 (Nubp1 and Nubp2). Nubp1 and Nubp2 also interact with each other.
    Title: Motor protein KIFC5A interacts with Nubp1 and Nubp2, and is implicated in the regulation of centrosome duplication.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent FeS chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in iron-sulfur cluster assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron-sulfur cluster assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole centrosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cytosolic Fe-S cluster assembly factor NUBP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355396.1 → NP_001342325.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166102
    Consensus CDS
    CCDS89014.1
    UniProtKB/TrEMBL
    A0A3Q4EH93
    Conserved Domains (1) summary
    pfam10609
    Location:1 → 203
    ParA; NUBPL iron-transfer P-loop NTPase

  2. NM_001379052.1 → NP_001365981.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC166102
    UniProtKB/TrEMBL
    A0A3Q4L2S1
    Conserved Domains (1) summary
    pfam10609
    Location:12 → 263
    ParA; NUBPL iron-transfer P-loop NTPase

  3. NM_001379053.1 → NP_001365982.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166102
    UniProtKB/TrEMBL
    A0A3Q4EH93
    Conserved Domains (1) summary
    pfam10609
    Location:1 → 203
    ParA; NUBPL iron-transfer P-loop NTPase

  4. NM_001379054.1 → NP_001365983.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166102
    UniProtKB/TrEMBL
    A0A3Q4EH93
    Conserved Domains (1) summary
    pfam10609
    Location:1 → 203
    ParA; NUBPL iron-transfer P-loop NTPase

  5. NM_001379055.1 → NP_001365984.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166102
    UniProtKB/TrEMBL
    A0A3Q4EH93
    Conserved Domains (1) summary
    pfam10609
    Location:1 → 203
    ParA; NUBPL iron-transfer P-loop NTPase

  6. NM_001379056.1 → NP_001365985.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166102
    UniProtKB/TrEMBL
    A0A3Q4EH93
    Related
    ENSMUSP00000157378.2, ENSMUST00000234928.2
    Conserved Domains (1) summary
    pfam10609
    Location:1 → 203
    ParA; NUBPL iron-transfer P-loop NTPase

  7. NM_011956.3 → NP_036086.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform 1

    See identical proteins and their annotated locations for NP_036086.1

    Status: VALIDATED

    Source sequence(s)
    AF114169, BI735707, BU700400
    Consensus CDS
    CCDS28500.1
    UniProtKB/Swiss-Prot
    Q9R061
    UniProtKB/TrEMBL
    A0A3Q4L2S1
    Related
    ENSMUSP00000049319.6, ENSMUST00000044252.7
    Conserved Domains (1) summary
    pfam10609
    Location:17 → 266
    ParA; NUBPL iron-transfer P-loop NTPase

RNA

  1. NR_166441.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166102
    Related
    ENSMUST00000234293.2

  2. NR_166442.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166102
    Related
    ENSMUST00000234261.2

  3. NR_166443.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166102
    Related
    ENSMUST00000234352.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25101585..25105423 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160624.1 → XP_036016517.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform X1

    UniProtKB/TrEMBL
    A0A3Q4EGU9
    Related
    ENSMUSP00000157175.2, ENSMUST00000234968.2
    Conserved Domains (1) summary
    pfam10609
    Location:44 → 256
    ParA; NUBPL iron-transfer P-loop NTPase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R061.1 GenPept UniProtKB/Swiss-Prot:Q9R061

Gene LinkOut

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