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Psg16 pregnancy specific beta-1-glycoprotein 16 [ Mus musculus (house mouse) ]

Gene ID: 26436, updated on 2-Nov-2024

Summary

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Official Symbol
Psg16provided by MGI
Official Full Name
pregnancy specific beta-1-glycoprotein 16provided by MGI
Primary source
MGI:MGI:1347249
See related
Ensembl:ENSMUSG00000066760 AllianceGenome:MGI:1347249
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PSG; bCEA; Cea11
Summary
Predicted to be involved in T cell activation and immune response. Located in cell surface. Is expressed in brain; lung; placenta; and spleen. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in placenta adult (RPKM 7.7) and cerebellum adult (RPKM 1.6) See more
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Genomic context

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See Psg16 in Genome Data Viewer
Location:
7 A2; 7 9.15 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (16807938..16867375)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (17074013..17133450)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 5, catalytic subunit Neighboring gene hypoxia inducible factor 3, alpha subunit Neighboring gene STARR-seq mESC enhancer starr_18149 Neighboring gene predicted gene 45219 Neighboring gene ribosomal protein L15 pseudogene Neighboring gene CEA cell adhesion molecule 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel full-length isoform of murine pregnancy-specific glycoprotein 16 (psg16) is expressed in the brain but does not mediate murine coronavirus (MHV) entry. Phillips JM, et al. J Neurovirol, 2012 Apr. PMID 22302612, Free PMC Article
  2. A pregnancy-specific glycoprotein is expressed in the brain and serves as a receptor for mouse hepatitis virus. Chen DS, et al. Proc Natl Acad Sci U S A, 1995 Dec 19. PMID 8618851, Free PMC Article
  3. Role of mouse hepatitis virus (MHV) receptor murine CEACAM1 in the resistance of mice to MHV infection: studies of mice with chimeric mCEACAM1a and mCEACAM1b. Hirai A, et al. J Virol, 2010 Jul. PMID 20410265, Free PMC Article
  4. Structure and evolution of the mouse pregnancy-specific glycoprotein (Psg) gene locus. McLellan AS, et al. BMC Genomics, 2005 Jan 12. PMID 15647114, Free PMC Article
  5. Effects of Pparγ1 deletion on late-stage murine embryogenesis and cells that undergo endocycle. Nakano T, et al. Dev Biol, 2021 Oct. PMID 34246625

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PSG16 does not mediate CEACAM1a-independent spread of murine coronavirus.
    Title: A novel full-length isoform of murine pregnancy-specific glycoprotein 16 (psg16) is expressed in the brain but does not mediate murine coronavirus (MHV) entry.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pregnancy specific glycoprotein 16
Names
carcinoembryonic antigen 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310628.1 → NP_001297557.1  pregnancy specific glycoprotein 16 isoform 1

    See identical proteins and their annotated locations for NP_001297557.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC148976
    Consensus CDS
    CCDS80666.1
    UniProtKB/TrEMBL
    Q60962, Q8K0U8
    Related
    ENSMUSP00000071348.7, ENSMUST00000071399.13
    Conserved Domains (4) summary
    cd05774
    Location:67 → 171
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00408
    Location:311 → 364
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:306 → 363
    IG_like; Immunoglobulin like
    cl11960
    Location:1 → 48
    Ig; Immunoglobulin domain

  2. NM_007676.4 → NP_031702.3  pregnancy specific glycoprotein 16 isoform 2

    See identical proteins and their annotated locations for NP_031702.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a 3' exon and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC030357, CK021085, U34272
    Consensus CDS
    CCDS20861.2
    UniProtKB/TrEMBL
    D0VY58, Q60962
    Related
    ENSMUSP00000113025.3, ENSMUST00000118367.3
    Conserved Domains (3) summary
    smart00408
    Location:311 → 369
    IGc2; Immunoglobulin C-2 Type
    cd05774
    Location:67 → 171
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cl11960
    Location:1 → 48
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    16807938..16867375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242606.1 → XP_030098466.1  pregnancy specific glycoprotein 16 isoform X1

    UniProtKB/TrEMBL
    Q60962
    Conserved Domains (2) summary
    cd05740
    Location:388 → 475
    IgI_hCEACAM_2_4_6_like; Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains
    cd05774
    Location:158 → 262
    IgV_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

  2. XM_030242607.1 → XP_030098467.1  pregnancy specific glycoprotein 16 isoform X2

    UniProtKB/TrEMBL
    D0VY58, Q60962
    Conserved Domains (3) summary
    smart00408
    Location:311 → 369
    IGc2; Immunoglobulin C-2 Type
    cd05774
    Location:67 → 171
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cl11960
    Location:1 → 48
    Ig; Immunoglobulin domain

  3. XM_036153135.1 → XP_036009028.1  pregnancy specific glycoprotein 16 isoform X1

    UniProtKB/TrEMBL
    Q60962
    Conserved Domains (2) summary
    cd05740
    Location:388 → 475
    IgI_hCEACAM_2_4_6_like; Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains
    cd05774
    Location:158 → 262
    IgV_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
Nucleotide Protein Strain
Heading Accession and Version

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