Dcps decapping enzyme, scavenger [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dcpsprovided by RGD
Official Full Name: decapping enzyme, scavengerprovided by RGD
Primary source: RGD:628887
See related: EnsemblRapid:ENSRNOG00000072197 AllianceGenome:RGD:628887
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: DCS-1; Hint-5
Summary: Predicted to enable RNA 7-methylguanosine cap binding activity; identical protein binding activity; and m7G(5')pppN diphosphatase activity. Predicted to be involved in cellular response to menadione; mRNA metabolic process; and negative regulation of programmed cell death. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Predicted to be active in P-body and nucleus. Orthologous to human DCPS (decapping enzyme, scavenger). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 158.9), Heart (RPKM 123.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q21

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (41729507..41782222, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (33468669..33524407, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (36321992..36374665, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048581 (e-PCR)
- UniSTS:145031

RH141913 (e-PCR)
- UniSTS:223904

AU047382 (e-PCR)
- UniSTS:110562

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity	ISO Inferred from Sequence Orthology more info
enables 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA 7-methylguanosine cap binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA 7-methylguanosine cap binding	IEA Inferred from Electronic Annotation more info
enables RNA 7-methylguanosine cap binding	ISO Inferred from Sequence Orthology more info
enables RNA 7-methylguanosine cap binding	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables sialyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA	IEA Inferred from Electronic Annotation more info
involved_in mRNA cis splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in mRNA cis splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA methylguanosine-cap decapping	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: m7GpppX diphosphatase

Names: decapping scavenger enzyme; hint-related 7meGMP-directed hydrolase; histidine triad nucleotide-binding protein 5; histidine triad protein member 5; mRNA decapping enzyme; scavenger mRNA-decapping enzyme DcpS

NP_695214.2

EC 3.6.1.59

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153302.2 → NP_695214.2 m7GpppX diphosphatase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

F1LPT1, Q3B8P4, Q5EBD4

Related

ENSRNOP00000013763.6, ENSRNOT00000013763.7

Conserved Domains (1) summary

COG5075
Location:45 → 319

COG5075; Uncharacterized conserved protein [Function unknown]