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Tor1a torsin family 1, member A [ Rattus norvegicus (Norway rat) ]

Gene ID: 266606, updated on 2-Nov-2024

Summary

Official Symbol
Tor1aprovided by RGD
Official Full Name
torsin family 1, member Aprovided by RGD
Primary source
RGD:628863
See related
EnsemblRapid:ENSRNOG00000006894 AllianceGenome:RGD:628863
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dyt1
Summary
Enables kinesin binding activity. Involved in response to oxidative stress. Located in growth cone; secretory granule; and synaptic vesicle. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita-5 and torsion dystonia 1. Orthologous to human TOR1A (torsin family 1 member A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 89.6), Thymus (RPKM 82.0) and 9 other tissues See more
Orthologs
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Genomic context

See Tor1a in Genome Data Viewer
Location:
3p12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (34648421..34655453, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (14250667..14257704, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (9800322..9807318, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene prostaglandin E synthase Neighboring gene torsin family 1, member B Neighboring gene similar to human chromosome 9 open reading frame 78 Neighboring gene ubiquitin specific peptidase 20

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP hydrolysis activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ATP-dependent protein folding chaperone ISO
Inferred from Sequence Orthology
more info
 
enables ATP-dependent protein folding chaperone ISS
Inferred from Sequence or Structural Similarity
more info
 
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables kinesin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables kinesin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables kinesin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
 
enables misfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in ERAD pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in chaperone cofactor-dependent protein refolding IEA
Inferred from Electronic Annotation
more info
 
involved_in chaperone-mediated protein folding ISO
Inferred from Sequence Orthology
more info
 
involved_in chaperone-mediated protein folding ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intermediate filament cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in intermediate filament cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within nuclear envelope organization ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear envelope organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in nuclear membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within nuclear membrane organization ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear membrane organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic vesicle endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein deneddylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein deneddylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of dopamine uptake involved in synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of dopamine uptake involved in synaptic transmission ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_positive_effect regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_positive_effect regulation of protein localization to cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic vesicle membrane organization ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle membrane organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in synaptic vesicle transport ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in wound healing, spreading of cells ISO
Inferred from Sequence Orthology
more info
 
involved_in wound healing, spreading of cells ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum lumen IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum lumen ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
torsin-1A
Names
dystonia 1 protein
dystonia 1, torsion (autosomal dominant
dystonia 1, torsion (autosomal dominant; torsin A)
torsin A
torsin ATPase 1
NP_695215.2
XP_038960324.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153303.2NP_695215.2  torsin-1A precursor

    See identical proteins and their annotated locations for NP_695215.2

    Status: PROVISIONAL

    Source sequence(s)
    BC078714
    UniProtKB/Swiss-Prot
    Q68G38, Q8K3L8
    Related
    ENSRNOP00000063691.2, ENSRNOT00000064660.5
    Conserved Domains (1) summary
    pfam06309
    Location:56170
    Torsin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    34648421..34655453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104396.2XP_038960324.1  torsin-1A isoform X1

    Conserved Domains (1) summary
    pfam06309
    Location:56170
    Torsin