Ppp1r17 protein phosphatase 1, regulatory subunit 17 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppp1r17provided by RGD
Official Full Name: protein phosphatase 1, regulatory subunit 17provided by RGD
Primary source: RGD:628647
See related: EnsemblRapid:ENSRNOG00000012235 AllianceGenome:RGD:628647
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gsbs
Summary: Enables phosphatase inhibitor activity. Predicted to be involved in regulation of phosphatase activity. Human ortholog(s) of this gene implicated in familial hypercholesterolemia. Orthologous to human PPP1R17 (protein phosphatase 1 regulatory subunit 17). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 53.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q24

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (86544024..86560839)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (85213595..85230607)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (86275130..86292435)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

G-substrate works as protein phosphatase 1 and 2A inhibitor upon phosphorylation by PKG.
Title: Thr123 of rat G-substrate contributes to its action as a protein phosphatase inhibitor.
retinal G-substrate plays a role as a downstream component of the NO-cGMP-PKG pathway. The co-localization of retinal G-substrate with protein Ser/Thr phosphatases suggests that it acts as an endogenous protein phosphatase inhibitor.
Title: Retinal G-substrate, potential downstream component of NO/cGMP/PKG pathway, is located in subtype of retinal ganglion cells and amacrine cells with protein phosphatases.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein phosphatase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in regulation of phosphatase activity	IEA Inferred from Electronic Annotation more info
involved_in regulation of phosphatase activity	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein phosphatase 1 regulatory subunit 17

Names: G-substrate

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.