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Pkig cAMP-dependent protein kinase inhibitor gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 266709, updated on 2-Nov-2024

Summary

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Official Symbol
Pkigprovided by RGD
Official Full Name
cAMP-dependent protein kinase inhibitor gammaprovided by RGD
Primary source
RGD:628775
See related
EnsemblRapid:ENSRNOG00000010235 AllianceGenome:RGD:628775
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables cAMP-dependent protein kinase inhibitor activity. Predicted to act upstream of or within negative regulation of protein import into nucleus; negative regulation of protein kinase activity; and negative regulation of transcription by RNA polymerase II. Predicted to be active in cytoplasm and nucleus. Orthologous to human PKIG (cAMP-dependent protein kinase inhibitor gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 124.0), Lung (RPKM 87.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pkig in Genome Data Viewer
Location:
3q42
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (172749871..172817514)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (152330477..152398085)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (160047257..160115180)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene alpha tocopherol transfer protein like Neighboring gene serine incorporator 3 Neighboring gene adenosine deaminase Neighboring gene uncharacterized LOC120101472

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Endogenous protein kinase inhibitor gamma terminates immediate-early gene expression induced by cAMP-dependent protein kinase (PKA) signaling: termination depends on PKA inactivation rather than PKA export from the nucleus. Chen X, et al. J Biol Chem, 2005 Jan 28. PMID 15557275
  2. Characterization of PKIgamma, a novel isoform of the protein kinase inhibitor of cAMP-dependent protein kinase. Collins SP, et al. J Biol Chem, 1997 Jul 18. PMID 9218452
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. endogenous levels of PKI regulate PKA signaling
    Title: Endogenous protein kinase inhibitor gamma terminates immediate-early gene expression induced by cAMP-dependent protein kinase (PKA) signaling: termination depends on PKA inactivation rather than PKA export from the nucleus.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC108574

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cAMP-dependent protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP-dependent protein kinase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cAMP-dependent protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cAMP-dependent protein kinase inhibitor gamma
Names
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
protein kinase inhibitor, gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401793.1 → NP_001388722.1  cAMP-dependent protein kinase inhibitor gamma

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JX43, A6JX44, Q6YH22
    Related
    ENSRNOP00000108043.1, ENSRNOT00000133815.1

  2. NM_001401794.1 → NP_001388723.1  cAMP-dependent protein kinase inhibitor gamma

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JX43, A6JX44, Q6YH22

  3. NM_001401795.1 → NP_001388724.1  cAMP-dependent protein kinase inhibitor gamma

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JX43, A6JX44, Q6YH22

  4. NM_001401796.1 → NP_001388725.1  cAMP-dependent protein kinase inhibitor gamma

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JX43, A6JX44, Q6YH22

  5. NM_001401797.1 → NP_001388726.1  cAMP-dependent protein kinase inhibitor gamma

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JX43, A6JX44, Q6YH22

  6. NM_153469.5 → NP_703199.1  cAMP-dependent protein kinase inhibitor gamma

    See identical proteins and their annotated locations for NP_703199.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JX43, A6JX44, Q6YH22
    Conserved Domains (1) summary
    pfam02827
    Location:2 → 70
    PKI; cAMP-dependent protein kinase inhibitor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    172749871..172817514
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283175.1 → XP_063139245.1  cAMP-dependent protein kinase inhibitor gamma isoform X3

  2. XM_008762470.4 → XP_008760692.1  cAMP-dependent protein kinase inhibitor gamma isoform X2

    See identical proteins and their annotated locations for XP_008760692.1

    UniProtKB/TrEMBL
    A6JX43, A6JX44, Q6YH22
    Conserved Domains (1) summary
    pfam02827
    Location:2 → 70
    PKI; cAMP-dependent protein kinase inhibitor

  3. XM_063283174.1 → XP_063139244.1  cAMP-dependent protein kinase inhibitor gamma isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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