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Slc17a3 solute carrier family 17 member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 266730, updated on 2-Nov-2024

Summary

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Official Symbol
Slc17a3provided by RGD
Official Full Name
solute carrier family 17 member 3provided by RGD
Primary source
RGD:628815
See related
EnsemblRapid:ENSRNOG00000032745 AllianceGenome:RGD:628815
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rnpt4
Summary
Predicted to enable several functions, including toxin transmembrane transporter activity; urate transmembrane transporter activity; and voltage-gated monoatomic anion channel activity. Predicted to be involved in several processes, including urate metabolic process; urate transport; and xenobiotic detoxification by transmembrane export across the plasma membrane. Predicted to be located in endoplasmic reticulum membrane and perinuclear region of cytoplasm. Predicted to be active in apical plasma membrane. Human ortholog(s) of this gene implicated in gout. Orthologous to human SLC17A3 (solute carrier family 17 member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 354.3) and Liver (RPKM 290.6) See more
Orthologs
human mouse all
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Genomic context

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See Slc17a3 in Genome Data Viewer
Location:
17p11
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (41698679..41729057, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (41270804..41300132, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (43518760..43545160, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 17, member 4 Neighboring gene solute carrier family 17 member 1 Neighboring gene uncharacterized LOC134482855 Neighboring gene solute carrier family 17, member 2 Neighboring gene H1.1 linker histone, cluster member Neighboring gene tripartite motif containing 38

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular effects of volume expansion on the renal sodium phosphate cotransporter. Puschett JB, et al. Am J Med Sci, 2003 Jul. PMID 12861119
  2. Identification of a new member of type I Na/phosphate co-transporter in the rat kidney. Ishibashi K, et al. Nephron Physiol, 2003. PMID 12806205
  3. Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. Jutabha P, et al. J Biol Chem, 2010 Nov 5. PMID 20810651, Free PMC Article
  4. NPT4, a new microsomal phosphate transporter: mutation analysis in glycogen storage disease type Ic. Melis D, et al. J Inherit Metab Dis, 2004. PMID 15505377
  5. Sex and age interaction with genetic association of atherogenic uric acid concentrations. Brandstätter A, et al. Atherosclerosis, 2010 Jun. PMID 20053405, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. effects of volume expansion on the renal sodium phosphate cotransporter
    Title: Molecular effects of volume expansion on the renal sodium phosphate cotransporter.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables efflux transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables efflux transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium:phosphate symporter activity TAS
Traceable Author Statement
more info
 PubMed 
enables toxin transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables toxin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables urate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables urate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated monoatomic anion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated monoatomic anion channel activity ISO
Inferred from Sequence Orthology
more info
  
enables xenobiotic transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables xenobiotic transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in monoatomic anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in organic anion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphate ion transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in urate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in urate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in urate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sodium-dependent phosphate transport protein 4
Names
Na/Pi cotransporter 4
sodium-phosphate cotransporter
solute carrier family 17 (organic anion transporter), member 3
solute carrier family 17 (sodium phosphate), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153622.2 → NP_705886.1  sodium-dependent phosphate transport protein 4

    See identical proteins and their annotated locations for NP_705886.1

    Status: PROVISIONAL

    Source sequence(s)
    AB025223
    UniProtKB/TrEMBL
    A6KLL0, Q8CJH9
    Related
    ENSRNOP00000029152.4, ENSRNOT00000029626.7
    Conserved Domains (2) summary
    cd06174
    Location:105 → 482
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00894
    Location:27 → 497
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    41698679..41729057 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253947.5 → XP_006254009.1  sodium-dependent phosphate transport protein 4 isoform X3

    UniProtKB/TrEMBL
    A6KLL0, Q6AZ69
    Conserved Domains (1) summary
    cd06174
    Location:145 → 493
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

  2. XM_063276121.1 → XP_063132191.1  sodium-dependent phosphate transport protein 4 isoform X8

  3. XM_063276119.1 → XP_063132189.1  sodium-dependent phosphate transport protein 4 isoform X5

  4. XM_006253941.5 → XP_006254003.1  sodium-dependent phosphate transport protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006254003.1

    UniProtKB/TrEMBL
    A6KLL0, Q6AZ69
    Conserved Domains (2) summary
    cd06174
    Location:145 → 522
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00894
    Location:71 → 537
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

  5. XM_063276118.1 → XP_063132188.1  sodium-dependent phosphate transport protein 4 isoform X4

  6. XM_006253942.5 → XP_006254004.1  sodium-dependent phosphate transport protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006254004.1

    UniProtKB/TrEMBL
    A6KLL0, Q6AZ69
    Conserved Domains (2) summary
    cd06174
    Location:145 → 522
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00894
    Location:71 → 537
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

  7. XM_063276120.1 → XP_063132190.1  sodium-dependent phosphate transport protein 4 isoform X6

    UniProtKB/TrEMBL
    A0A0G2JY28
    Related
    ENSRNOP00000070495.2, ENSRNOT00000091749.3

  8. XM_063276117.1 → XP_063132187.1  sodium-dependent phosphate transport protein 4 isoform X2

    UniProtKB/TrEMBL
    A6KLL2, E9PTR8

  9. XM_063276116.1 → XP_063132186.1  sodium-dependent phosphate transport protein 4 isoform X1

  10. XM_039095421.2 → XP_038951349.1  sodium-dependent phosphate transport protein 4 isoform X7

    Conserved Domains (1) summary
    TIGR00894
    Location:71 → 394
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
Nucleotide Protein Strain
Heading Accession and Version

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