Zfp597 zinc finger protein 597 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zfp597provided by RGD
Official Full Name: zinc finger protein 597provided by RGD
Primary source: RGD:628674
See related: EnsemblRapid:ENSRNOG00000088895 AllianceGenome:RGD:628674
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hit4; Znf597
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF597 (zinc finger protein 597). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 230.8), Brain (RPKM 132.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (12159533..12165207)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (11653169..11658843)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (11912245..11917919)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results reveal novel biological and pathological roles of HIT-4 in brain development and/or maintenance in rats.
Title: Molecular characterization and gene disruption of a novel zinc-finger protein, HIT-4, expressed in rodent brain.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 597

Names: zinc finger protein HIT-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153732.2 → NP_714954.2 zinc finger protein 597

See identical proteins and their annotated locations for NP_714954.2

Status: VALIDATED

Source sequence(s)

BC078709

UniProtKB/TrEMBL

A6K4U7, F1LLV0, Q6AZ70

Related

ENSRNOP00000111089.1, ENSRNOT00000158077.1

Conserved Domains (4) summary

sd00017
Location:156 → 176

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:182 → 204

zf-C2H2; Zinc finger, C2H2 type

pfam01352
Location:16 → 50

KRAB; KRAB box

pfam13465
Location:196 → 221

zf-H2C2_2; Zinc-finger double domain