U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Prl3a1 prolactin family 3, subfamily A, member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 266782, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Prl3a1provided by RGD
Official Full Name
prolactin family 3, subfamily A, member 1provided by RGD
Primary source
RGD:731250
See related
EnsemblRapid:ENSRNOG00000017103 AllianceGenome:RGD:731250
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Plpi; Ghd14; PLP-I
Summary
Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 8.1) See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Prl3a1 in Genome Data Viewer
Location:
17p12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (37901976..37920288, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (37693595..37711904, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (42723745..42740021, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene prolactin family 8, subfamily A, member 2 Neighboring gene prolactin family 6, subfamily A, member 1 Neighboring gene prolactin family 3, subfamily B, member 1 Neighboring gene prolactin family 3, subfamily C, member 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of four new members of the rat prolactin/growth hormone gene family. Ishibashi K, et al. Biochem Biophys Res Commun, 1999 Sep 7. PMID 10471365
  2. The mouse prolactin gene family locus. Wiemers DO, et al. Endocrinology, 2003 Jan. PMID 12488360
  3. Curated eutherian third party data gene data sets. Premzl M. Data Brief, 2016 Mar. PMID 26862561, Free PMC Article
  4. Third party data gene data set of eutherian growth hormone genes. Premzl M. Genom Data, 2015 Dec. PMID 26697363, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables prolactin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in female pregnancy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mammary gland development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of lactation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to nutrient levels IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
prolactin family 3, subfamily A, member 1
Names
growth hormone d14
prolactin like protein I

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153736.3 → NP_714958.1  prolactin family 3, subfamily A, member 1 precursor

    See identical proteins and their annotated locations for NP_714958.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A0A0G2JYV6, A0A0M6L0N5, A6J7S7, F7FKY9, Q8K3W4
    Related
    ENSRNOP00000023063.4, ENSRNOT00000023063.5
    Conserved Domains (1) summary
    cd10288
    Location:30 → 227
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    37901976..37920288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095422.2 → XP_038951350.1  prolactin family 3, subfamily A, member 1 isoform X1

    UniProtKB/TrEMBL
    A6J7S8
    Conserved Domains (1) summary
    cd10288
    Location:8 → 165
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

  2. XM_039095424.2 → XP_038951352.1  prolactin family 3, subfamily A, member 1 isoform X2

    UniProtKB/TrEMBL
    A6J7S8
    Conserved Domains (1) summary
    cd10288
    Location:2 → 159
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools