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Eaf2 ELL associated factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 266787, updated on 10-Jul-2024

Summary

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Official Symbol
Eaf2provided by RGD
Official Full Name
ELL associated factor 2provided by RGD
Primary source
RGD:628879
See related
EnsemblRapid:ENSRNOG00000002350 AllianceGenome:RGD:628879
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Traits
Summary
Predicted to enable transcription elongation regulator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and regulation of transcription elongation from RNA polymerase II promoter. Predicted to act upstream of or within negative regulation of cell growth and negative regulation of epithelial cell proliferation involved in prostate gland development. Predicted to be located in nucleoplasm. Predicted to be part of transcription elongation factor complex. Orthologous to human EAF2 (ELL associated factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 14.5), Kidney (RPKM 9.8) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Eaf2 in Genome Data Viewer
Location:
11q21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (77465585..77509993)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (63960200..64004610)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (66878658..66923092)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene golgin B1 Neighboring gene IQ motif containing B1 Neighboring gene solute carrier family 15 member 2 Neighboring gene RNA guanylyltransferase and 5'-phosphatase, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia. Xiao W, et al. Oncogene, 2008 Mar 6. PMID 17873910, Free PMC Article
  2. ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation. Xiao W, et al. Prostate, 2006 Jan 1. PMID 16114057
  3. Suppression of prostate tumor growth by U19, a novel testosterone-regulated apoptosis inducer. Xiao W, et al. Cancer Res, 2003 Aug 1. PMID 12907652
  4. Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II. Saso K, et al. J Biochem, 2003 Apr. PMID 12761297
  5. The super elongation complex (SEC) family in transcriptional control. Luo Z, et al. Nat Rev Mol Cell Biol, 2012 Sep. PMID 22895430

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transcription elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription elongation factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of epithelial cell proliferation involved in prostate gland development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of epithelial cell proliferation involved in prostate gland development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription elongation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of super elongation complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription elongation factor complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription elongation factor complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ELL-associated factor 2
Names
testosterone regulated apoptosis inducer and tumor suppressor
testosterone-regulated apoptosis inducer and tumor suppressor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172047.1 → NP_742044.1  ELL-associated factor 2

    See identical proteins and their annotated locations for NP_742044.1

    Status: PROVISIONAL

    Source sequence(s)
    AY049022
    UniProtKB/Swiss-Prot
    Q811X5
    UniProtKB/TrEMBL
    A6IRB1
    Related
    ENSRNOP00000003208.5, ENSRNOT00000003208.7
    Conserved Domains (1) summary
    pfam09816
    Location:17 → 113
    EAF; RNA polymerase II transcription elongation factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    77465585..77509993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270315.1 → XP_063126385.1  ELL-associated factor 2 isoform X1

    UniProtKB/TrEMBL
    A6IRB3

  2. XM_039088054.2 → XP_038943982.1  ELL-associated factor 2 isoform X1

    UniProtKB/TrEMBL
    A6IRB3

  3. XM_039088053.2 → XP_038943981.1  ELL-associated factor 2 isoform X1

    UniProtKB/TrEMBL
    A6IRB3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q811X5.1 GenPept UniProtKB/Swiss-Prot:Q811X5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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