pqn-59 Prion-like (glutamine/asparagine-rich) domain bearing protein pqn-59 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pqn-59
Official Full Name: Prion-like (glutamine/asparagine-rich) domain bearing protein pqn-59
Primary source: WormBase:WBGene00004143
Locus tag: CELE_R119.4
See related: AllianceGenome:WB:WBGene00004143
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be active in cytoplasm and nucleus. Is expressed widely. Orthologous to several human genes including UBAP2L (ubiquitin associated protein 2 like). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pqn-59 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (379071..381902, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PQN-59 antagonizes microRNA-mediated repression during post-embryonic temporal patterning and modulates translation and stress granule formation in C. elegans.
Title: PQN-59 antagonizes microRNA-mediated repression during post-embryonic temporal patterning and modulates translation and stress granule formation in C. elegans.
PQN-59 and GTBP-1 contribute to stress granule formation but are not essential for their assembly in C. elegans embryos.
Title: PQN-59 and GTBP-1 contribute to stress granule formation but are not essential for their assembly in C. elegans embryos.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R119.4 (e-PCR)
- UniSTS:305693

R119.3 (e-PCR)
- UniSTS:317794

STS1-148 (e-PCR)
- UniSTS:241634

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Prion-like (glutamine/asparagine-rich) domain bearing protein pqn-59

NP_490727.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

379071..381902 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058326.8 → NP_490727.1 Prion-like (glutamine/asparagine-rich) domain bearing protein pqn-59 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_490727.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O61708

Conserved Domains (1) summary

cd14277
Location:31 → 68

UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins