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dao-5 Nucleolar protein dao-5 [ Caenorhabditis elegans ]

Gene ID: 266845, updated on 2-Nov-2024

Summary

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Official Symbol
dao-5
Official Full Name
Nucleolar protein dao-5
Primary source
WormBase:WBGene00000931
Locus tag
CELE_C25A1.10
See related
AllianceGenome:WB:WBGene00000931
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables RNA polymerase I core binding activity and rDNA binding activity. Involved in several processes, including determination of adult lifespan; insulin receptor signaling pathway; and nucleolar large rRNA transcription by RNA polymerase I. Located in nucleolus and nucleoplasm. Is expressed in several structures, including germ line; germline precursor cell; gonadal sheath cell; nervous system; and somatic cell. Orthologous to human NOLC1 (nucleolar and coiled-body phosphoprotein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dao-5 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003279.8 (10187546..10190896, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Proteasome assembly chaperone 3 Neighboring gene isoleucine--tRNA ligase Neighboring gene C-type lectin domain-containing protein 87 Neighboring gene Serine/threonine-protein phosphatase 2A regulatory subunit rsa-1 Neighboring gene AB hydrolase-1 domain-containing protein;Abhydrolase domain-containing protein lid-1 Neighboring gene Large ribosomal subunit protein mL43 Neighboring gene Aryl hydrocarbon receptor nuclear translocator homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutation of a Nopp140 gene dao-5 alters rDNA transcription and increases germ cell apoptosis in C. elegans. Lee CC, et al. Cell Death Dis, 2014 Apr 10. PMID 24722283, Free PMC Article
  2. Nucleologenesis in the Caenorhabditis elegans embryo. Korčeková D, et al. PLoS One, 2012. PMID 22768349, Free PMC Article
  3. Aging disrupts spatiotemporal regulation of germline stem cells and niche integrity. Urman MA, et al. Biol Open, 2024 Jan 15. PMID 38156664, Free PMC Article
  4. Notch-dependent DNA cis-regulatory elements and their dose-dependent control of C. elegans stem cell self-renewal. Lynch TR, et al. Development, 2022 Apr 1. PMID 35394007, Free PMC Article
  5. Expansion microscopy of C. elegans. Yu CJ, et al. Elife, 2020 May 1. PMID 32356725, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A null dao-5 mutant ok542 with a semi-infertile phenotype showed a delay in gonadogenesis, as well as a higher incidence of germline apoptosis.[dao-5]
    Title: Mutation of a Nopp140 gene dao-5 alters rDNA transcription and increases germ cell apoptosis in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA polymerase I core binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables rDNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in dauer larval development TAS
Traceable Author Statement
more info
 PubMed 
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in insulin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nucleolar large rRNA transcription by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of rDNA heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nucleolar protein dao-5
NP_001021004.1
  • Confirmed by transcript evidence
NP_001021005.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    10187546..10190896 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001025833.10 → NP_001021004.1  Nucleolar protein dao-5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021004.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q564W7, Q9XVS4
    Conserved Domains (4) summary
    pfam05022
    Location:897 → 945
    SRP40_C; SRP40, C-terminal domain
    cl26128
    Location:196 → 321
    tRNA-synt_1g; tRNA synthetases class I (M)
    cl26386
    Location:389 → 606
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl26464
    Location:445 → 886
    Atrophin-1; Atrophin-1 family

  2. NM_001025834.6 → NP_001021005.1  Nucleolar protein dao-5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021005.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q564W7
    Conserved Domains (1) summary
    pfam05022
    Location:622 → 670
    SRP40_C; SRP40, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XVS4.1

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