prdx-2 Peroxiredoxin prdx-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: prdx-2
Official Full Name: Peroxiredoxin prdx-2
Primary source: WormBase:WBGene00006434
Locus tag: CELE_F09E5.15
See related: AllianceGenome:WB:WBGene00006434
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables thioredoxin peroxidase activity. Involved in several processes, including cellular response to hydrogen peroxide; determination of adult lifespan; and positive regulation of brood size. Located in cytoplasm. Is expressed in several structures, including intestine; nervous system; pharynx; reproductive system; and tail. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblC. Orthologous to human PRDX1 (peroxiredoxin 1) and PRDX2 (peroxiredoxin 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See prdx-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 4

Sequence:: Chromosome: II; NC_003280.10 (5378195..5379631)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Peroxiredoxin 2 regulates DAF-16/FOXO mediated mitochondrial remodelling in response to exercise that is disrupted in ageing.
Title: Peroxiredoxin 2 regulates DAF-16/FOXO mediated mitochondrial remodelling in response to exercise that is disrupted in ageing.
Redox-stress response resistance (RRR) mediated by hyperoxidation of peroxiredoxin 2 in senescent cells.
Title: Redox-stress response resistance (RRR) mediated by hyperoxidation of peroxiredoxin 2 in senescent cells.
Peroxiredoxin 2 is required for the redox mediated adaptation to exercise.
Title: Peroxiredoxin 2 is required for the redox mediated adaptation to exercise.
Early developmental nanoplastics exposure disturbs circadian rhythms associated with stress resistance decline and modulated by DAF-16 and PRDX-2 in C. elegans.
Title: Early developmental nanoplastics exposure disturbs circadian rhythms associated with stress resistance decline and modulated by DAF-16 and PRDX-2 in C. elegans.
Analysis of the in vivo redox status demonstrated that at 25 degrees C, C. elegans larvae have a more reduced redox state and higher Prdx-2 expression levels than animals raised at 15 degrees C. Worms lacking prdx-2 fail to show the additional lifespan extension upon shift from 25 degrees C to 15 degrees C and reveal a lifespan similar to prdx-2 worms always kept at 15 degrees C.
Title: Do developmental temperatures affect redox level and lifespan in C. elegans through upregulation of peroxiredoxin?
PRDX-2 is required for insulin secretion and insulin/IGF-1-dependent regulation of stress resistance and longevity.
Title: A peroxiredoxin, PRDX-2, is required for insulin secretion and insulin/IIS-dependent regulation of stress resistance and longevity.
PRDX2 has a role in Metformin promotion of lifespan through mitohormesis
Title: Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2.
While PRDX-2 acts in the intestine to protect against environmental stress, PRDX-2 in other tissues influences endogenous mechanisms that promote longevity.
Title: A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables antioxidant activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IEA Inferred from Electronic Annotation more info
enables peroxiredoxin activity	IEA Inferred from Electronic Annotation more info
enables thioredoxin peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thioredoxin peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables thioredoxin-dependent peroxiredoxin activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heat acclimation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hydrogen peroxide catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of brood size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in removal of superoxide radicals	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to chemical	IEA Inferred from Electronic Annotation more info
involved_in response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to metal ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Peroxiredoxin prdx-2

NP_001300536.1

Partially confirmed by transcript evidence

NP_001367731.1

Confirmed by transcript evidence

NP_001370635.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

5378195..5379631

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001381416.1 → NP_001367731.1 Peroxiredoxin prdx-2 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd03015
Location:10 → 181

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
NM_001313607.3 → NP_001300536.1 Peroxiredoxin prdx-2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0K3AUJ9, H2KZL7, Q8IG31

Conserved Domains (1) summary

cd03015
Location:12 → 183

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
NM_001383831.2 → NP_001370635.1 Peroxiredoxin prdx-2 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd03015
Location:6 → 177

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...