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rnh-2 Ribonuclease H2 subunit A [ Caenorhabditis elegans ]

Gene ID: 266861, updated on 2-Nov-2024

Summary

Official Symbol
rnh-2
Official Full Name
Ribonuclease H2 subunit A
Primary source
WormBase:WBGene00004383
Locus tag
CELE_T13H5.7
See related
AllianceGenome:WB:WBGene00004383
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA-DNA hybrid ribonuclease activity. Predicted to be involved in DNA replication, removal of RNA primer and mismatch repair. Predicted to be part of ribonuclease H2 complex. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2A (ribonuclease H2 subunit A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See rnh-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (8517150..8518407)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Receptor-type tyrosine-protein phosphatase kappa;Receptor-type tyrosine-protein phosphatase mu;Tyrosine-protein phosphatase domain-containing protein Neighboring gene DB domain-containing protein Neighboring gene CRAL-TRIO domain-containing protein Neighboring gene Lipid scramblase CLPTM1L Neighboring gene GH18 domain-containing protein

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA-DNA hybrid ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA-DNA hybrid ribonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA replication, removal of RNA primer IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in RNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nucleic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of ribonuclease H2 complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
Ribonuclease H2 subunit A
NP_495796.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    8517150..8518407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063395.5NP_495796.1  Ribonuclease H2 subunit A [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495796.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U6P6
    Conserved Domains (1) summary
    cd07181
    Location:24248
    RNase_HII_eukaryota_like; Eukaryotic RNase HII