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spsb-2 SPRY domain-containing SOCS box protein 1 [ Caenorhabditis elegans ]

Gene ID: 266877, updated on 2-Nov-2024

Summary

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Official Symbol
spsb-2
Official Full Name
SPRY domain-containing SOCS box protein 1
Primary source
WormBase:WBGene00021596
Locus tag
CELE_Y46E12BL.3
See related
AllianceGenome:WB:WBGene00021596
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in hypodermis and intestine. Orthologous to several human genes including SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See spsb-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (15230343..15232803)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene B30.2/SPRY domain-containing protein;SPRY domain-containing SOCS box protein 1;SPRY domain-containing SOCS box protein 4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal RNA-processing protein 12-like conserved domain-containing protein Neighboring gene TGF-beta family profile domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SPRY domain-containing SOCS box protein 1
NP_497320.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    15230343..15232803
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_064919.7 → NP_497320.2  SPRY domain-containing SOCS box protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497320.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q965N7
    Conserved Domains (2) summary
    cd03718
    Location:200 → 241
    SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...
    cd12906
    Location:25 → 194
    SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)
Nucleotide Protein
Heading Accession and Version

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