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ttn-1 Ig-like domain-containing protein;Titin;Titin homolog [ Caenorhabditis elegans ]

Gene ID: 266969, updated on 2-Nov-2024

Summary

Official Symbol
ttn-1
Official Full Name
Ig-like domain-containing protein;Titin;Titin homolog
Primary source
WormBase:WBGene00006436
Locus tag
CELE_W06H8.8
See related
AllianceGenome:WB:WBGene00006436
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables actin filament binding activity and myosin binding activity. Predicted to be involved in axon guidance and protein phosphorylation. Located in A band and I band. Is expressed in body wall musculature; muscle cell; and reproductive system. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See ttn-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
65
Sequence:
Chromosome: V; NC_003283.11 (6120909..6202632, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene One cut domain family member Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene BTB domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables myosin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in A band IDA
Inferred from Direct Assay
more info
PubMed 
located_in A band IEA
Inferred from Electronic Annotation
more info
 
located_in I band IDA
Inferred from Direct Assay
more info
PubMed 
located_in I band IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in organelle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Ig-like domain-containing protein;Titin;Titin homolog
NP_001024200.1
  • Confirmed by transcript evidence
NP_001346715.1
  • Partially confirmed by transcript evidence
NP_001346716.1
  • Partially confirmed by transcript evidence
NP_001346722.1
  • Partially confirmed by transcript evidence
NP_001346723.1
  • Partially confirmed by transcript evidence
NP_001346724.1
  • Confirmed by transcript evidence
NP_001360072.1
  • Partially confirmed by transcript evidence
NP_001367912.1
  • Partially confirmed by transcript evidence
NP_001367913.1
  • Partially confirmed by transcript evidence
NP_001367914.1
  • Partially confirmed by transcript evidence
NP_001368671.1
  • Partially confirmed by transcript evidence
NP_001368672.1
  • Partially confirmed by transcript evidence
NP_001368673.1
  • Partially confirmed by transcript evidence
NP_001368674.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    6120909..6202632 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373034.1NP_001360072.1  Titin homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A7DT28, G4SLD6, G4SLH0, G5EDP1, G5EDT5, G5EF69, G5EFF0, Q65XY2, Q8ISF3, Q8ISF4
    Conserved Domains (14) summary
    PTZ00121
    Location:958310392
    PTZ00121; MAEBL; Provisional
    smart00409
    Location:1475414838
    IG; Immunoglobulin
    smart00410
    Location:1117911259
    IG_like; Immunoglobulin like
    PHA03247
    Location:19572285
    PHA03247; large tegument protein UL36; Provisional
    COG5271
    Location:76878197
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    PRK09510
    Location:65596683
    tolA; cell envelope integrity inner membrane protein TolA; Provisional
    PRK10263
    Location:40144556
    PRK10263; DNA translocase FtsK; Provisional
    PRK10811
    Location:43464567
    rne; ribonuclease E; Reviewed
    cd00063
    Location:1077710870
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:1324913314
    Ig; Immunoglobulin domain
    pfam07679
    Location:1312313206
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:1505515132
    Ig_3; Immunoglobulin domain
    cl11960
    Location:1398414074
    Ig; Immunoglobulin domain
    cl21453
    Location:1256612815
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001359768.3NP_001346715.1  Titin homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A7DT28, G4SLD6, G4SLH0, G5EDP1, G5EDT5, G5EF69, G5EFF0, Q65XY2, Q8ISF3, Q8ISF4
    Conserved Domains (15) summary
    smart00409
    Location:1117911259
    IG; Immunoglobulin
    smart00410
    Location:1475414838
    IG_like; Immunoglobulin like
    cd00063
    Location:1077710870
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1312313206
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:1505415132
    Ig_3; Immunoglobulin domain
    cd00096
    Location:1324913314
    Ig; Immunoglobulin domain
    cl11960
    Location:1233712411
    Ig; Immunoglobulin domain
    cl21453
    Location:1256612815
    PKc_like; Protein Kinases, catalytic domain
    cl25545
    Location:65596683
    V-ATPase_G_2; Vacuolar (H+)-ATPase G subunit
    cl26464
    Location:19572285
    Atrophin-1; Atrophin-1 family
    cl26511
    Location:958310392
    Neuromodulin_N; Gap junction protein N-terminal region
    cl26557
    Location:43464567
    RNase_E_G; Ribonuclease E/G family
    cl26761
    Location:76878197
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cl28087
    Location:40144556
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
    cl28434
    Location:1398414074
    I-set; Immunoglobulin I-set domain
  3. NM_001380658.2NP_001367913.1  Titin homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A7DT28, G4SLD6, G4SLH0, G5EDP1, G5EDT5, G5EF69, G5EFF0, Q65XY2, Q8ISF3, Q8ISF4
    Conserved Domains (14) summary
    PTZ00121
    Location:958310392
    PTZ00121; MAEBL; Provisional
    smart00409
    Location:1059710662
    IG; Immunoglobulin
    smart00410
    Location:1473914823
    IG_like; Immunoglobulin like
    PHA03247
    Location:19572285
    PHA03247; large tegument protein UL36; Provisional
    COG5271
    Location:76878197
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    PRK09510
    Location:65596683
    tolA; cell envelope integrity inner membrane protein TolA; Provisional
    PRK10263
    Location:40144556
    PRK10263; DNA translocase FtsK; Provisional
    PRK10811
    Location:43464567
    rne; ribonuclease E; Reviewed
    cd00063
    Location:1077710870
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1310813191
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:1406814144
    Ig_3; Immunoglobulin domain
    cd00096
    Location:1323413302
    Ig; Immunoglobulin domain
    cl11960
    Location:1354313635
    Ig; Immunoglobulin domain
    cl21453
    Location:1256612815
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001359765.3NP_001346723.1  Titin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2I2LG13
    Conserved Domains (15) summary
    smart00409
    Location:1017110236
    IG; Immunoglobulin
    smart00410
    Location:1431314397
    IG_like; Immunoglobulin like
    cd00063
    Location:1035110444
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1268212765
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:1461314691
    Ig_3; Immunoglobulin domain
    cd00096
    Location:1280812873
    Ig; Immunoglobulin domain
    cl11960
    Location:1191111985
    Ig; Immunoglobulin domain
    cl21453
    Location:1214012389
    PKc_like; Protein Kinases, catalytic domain
    cl25545
    Location:61336257
    V-ATPase_G_2; Vacuolar (H+)-ATPase G subunit
    cl26464
    Location:15311859
    Atrophin-1; Atrophin-1 family
    cl26511
    Location:91579966
    Neuromodulin_N; Gap junction protein N-terminal region
    cl26557
    Location:39204141
    RNase_E_G; Ribonuclease E/G family
    cl26761
    Location:72617771
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cl28087
    Location:35884130
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
    cl28434
    Location:1354313633
    I-set; Immunoglobulin I-set domain
  5. NM_001359766.3NP_001346716.1  Titin homolog [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (14) summary
    smart00409
    Location:1432814412
    IG; Immunoglobulin
    cd00063
    Location:1035110444
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1269712780
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:1462814706
    Ig_3; Immunoglobulin domain
    cd00096
    Location:1282312888
    Ig; Immunoglobulin domain
    cl11960
    Location:1191111985
    Ig; Immunoglobulin domain
    cl21453
    Location:1214012389
    PKc_like; Protein Kinases, catalytic domain
    cl25545
    Location:61336257
    V-ATPase_G_2; Vacuolar (H+)-ATPase G subunit
    cl26464
    Location:15311859
    Atrophin-1; Atrophin-1 family
    cl26511
    Location:91579966
    Neuromodulin_N; Gap junction protein N-terminal region
    cl26557
    Location:39204141
    RNase_E_G; Ribonuclease E/G family
    cl26761
    Location:72617771
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cl28087
    Location:35884130
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
    cl28434
    Location:1355813648
    I-set; Immunoglobulin I-set domain
  6. NM_001359767.3NP_001346722.1  Titin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A7DT28, G4SLD6, G4SLH0, G5EDP1, G5EDT5, G5EF69, G5EFF0, Q65XY2, Q8ISF3, Q8ISF4
    UniProtKB/TrEMBL
    A0A2I2LDV7
    Conserved Domains (15) summary
    smart00409
    Location:1473914823
    IG; Immunoglobulin
    smart00410
    Location:1117911259
    IG_like; Immunoglobulin like
    cd00063
    Location:1077710870
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1310813191
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:1503915117
    Ig_3; Immunoglobulin domain
    cd00096
    Location:1323413299
    Ig; Immunoglobulin domain
    cl11960
    Location:1233712411
    Ig; Immunoglobulin domain
    cl21453
    Location:1256612815
    PKc_like; Protein Kinases, catalytic domain
    cl25545
    Location:65596683
    V-ATPase_G_2; Vacuolar (H+)-ATPase G subunit
    cl26464
    Location:19572285
    Atrophin-1; Atrophin-1 family
    cl26511
    Location:958310392
    Neuromodulin_N; Gap junction protein N-terminal region
    cl26557
    Location:43464567
    RNase_E_G; Ribonuclease E/G family
    cl26761
    Location:76878197
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cl28087
    Location:40144556
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
    cl28434
    Location:1396914059
    I-set; Immunoglobulin I-set domain
  7. NM_001380654.1NP_001368672.1  Titin homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2I2LDV8
    Conserved Domains (9) summary
    PTZ00121
    Location:22533062
    PTZ00121; MAEBL; Provisional
    smart00409
    Location:74097493
    IG; Immunoglobulin
    smart00410
    Location:32673332
    IG_like; Immunoglobulin like
    cd00063
    Location:34473540
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:57785861
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:67386814
    Ig_3; Immunoglobulin domain
    cd00096
    Location:59045972
    Ig; Immunoglobulin domain
    cl11960
    Location:62136305
    Ig; Immunoglobulin domain
    cl21453
    Location:52365485
    PKc_like; Protein Kinases, catalytic domain
  8. NM_001380655.1NP_001368671.1  Titin homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2I2LDW1
    Conserved Domains (9) summary
    PTZ00121
    Location:22533062
    PTZ00121; MAEBL; Provisional
    smart00409
    Location:32673332
    IG; Immunoglobulin
    smart00410
    Location:74247508
    IG_like; Immunoglobulin like
    cd00063
    Location:34473540
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:57935876
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:67536829
    Ig_3; Immunoglobulin domain
    cd00096
    Location:59195987
    Ig; Immunoglobulin domain
    cl11960
    Location:62286320
    Ig; Immunoglobulin domain
    cl21453
    Location:52365485
    PKc_like; Protein Kinases, catalytic domain
  9. NM_001380657.1NP_001367912.1  Titin homolog [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (13) summary
    PTZ00121
    Location:91579966
    PTZ00121; MAEBL; Provisional
    smart00409
    Location:1432814412
    IG; Immunoglobulin
    PHA03247
    Location:15311859
    PHA03247; large tegument protein UL36; Provisional
    COG5271
    Location:72617771
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    PRK09510
    Location:61336257
    tolA; cell envelope integrity inner membrane protein TolA; Provisional
    PRK10263
    Location:35884130
    PRK10263; DNA translocase FtsK; Provisional
    PRK10811
    Location:39204141
    rne; ribonuclease E; Reviewed
    cd00063
    Location:1035110444
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1269712780
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:1365713733
    Ig_3; Immunoglobulin domain
    cd00096
    Location:1282312891
    Ig; Immunoglobulin domain
    cl11960
    Location:1313213224
    Ig; Immunoglobulin domain
    cl21453
    Location:1214012389
    PKc_like; Protein Kinases, catalytic domain
  10. NM_001380656.1NP_001367914.1  Titin homolog [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (14) summary
    PTZ00121
    Location:91579966
    PTZ00121; MAEBL; Provisional
    smart00409
    Location:105177
    IG; Immunoglobulin
    smart00410
    Location:1431314397
    IG_like; Immunoglobulin like
    PHA03247
    Location:15311859
    PHA03247; large tegument protein UL36; Provisional
    COG5271
    Location:72617771
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    PRK09510
    Location:61336257
    tolA; cell envelope integrity inner membrane protein TolA; Provisional
    PRK10263
    Location:35884130
    PRK10263; DNA translocase FtsK; Provisional
    PRK10811
    Location:39204141
    rne; ribonuclease E; Reviewed
    cd00063
    Location:1035110444
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1268212765
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:1364213718
    Ig_3; Immunoglobulin domain
    cd00096
    Location:1280812876
    Ig; Immunoglobulin domain
    cl11960
    Location:1311713209
    Ig; Immunoglobulin domain
    cl21453
    Location:1214012389
    PKc_like; Protein Kinases, catalytic domain
  11. NM_001380659.1NP_001368674.1  Titin homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2I2LDX0
    Conserved Domains (8) summary
    PTZ00121
    Location:22533062
    PTZ00121; MAEBL; Provisional
    smart00410
    Location:74097493
    IG_like; Immunoglobulin like
    cd00063
    Location:34473540
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:57785861
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:67386814
    Ig_3; Immunoglobulin domain
    cd00096
    Location:59045972
    Ig; Immunoglobulin domain
    cl11960
    Location:62136305
    Ig; Immunoglobulin domain
    cl21453
    Location:52365485
    PKc_like; Protein Kinases, catalytic domain
  12. NM_001380660.1NP_001368673.1  Titin homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2I2LG61
    Conserved Domains (9) summary
    PTZ00121
    Location:22533062
    PTZ00121; MAEBL; Provisional
    smart00409
    Location:32673332
    IG; Immunoglobulin
    smart00410
    Location:74247508
    IG_like; Immunoglobulin like
    cd00063
    Location:34473540
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:57935876
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:67536829
    Ig_3; Immunoglobulin domain
    cd00096
    Location:59195987
    Ig; Immunoglobulin domain
    cl11960
    Location:62286320
    Ig; Immunoglobulin domain
    cl21453
    Location:52365485
    PKc_like; Protein Kinases, catalytic domain
  13. NM_001029029.5NP_001024200.1  Titin homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024200.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G4SLH0
    Conserved Domains (6) summary
    cd00096
    Location:839908
    Ig; Immunoglobulin domain
    smart00408
    Location:16921758
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:31123180
    IG; Immunoglobulin
    smart00410
    Location:11441224
    IG_like; Immunoglobulin like
    pfam07679
    Location:16791767
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:11511215
    Ig; Immunoglobulin domain
  14. NM_001359777.3NP_001346724.1  Ig-like domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2I2LDV4
    Conserved Domains (7) summary
    smart00409
    Location:105177
    IG; Immunoglobulin
    smart00410
    Location:26862754
    IG_like; Immunoglobulin like
    pfam07679
    Location:12531341
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:536606
    Ig; Immunoglobulin domain
    cl25732
    Location:15371805
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28033
    Location:18832029
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    cl28434
    Location:395488
    I-set; Immunoglobulin I-set domain