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Scml4 Scm polycomb group protein like 4 [ Mus musculus (house mouse) ]

Gene ID: 268297, updated on 2-Nov-2024

Summary

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Official Symbol
Scml4provided by MGI
Official Full Name
Scm polycomb group protein like 4provided by MGI
Primary source
MGI:MGI:2446140
See related
Ensembl:ENSMUSG00000044770 AllianceGenome:MGI:2446140
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mFLJ00197; 9330161D17
Summary
Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in dorsal root ganglion. Orthologous to human SCML4 (Scm polycomb group protein like 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in spleen adult (RPKM 3.2), thymus adult (RPKM 2.9) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Scml4 in Genome Data Viewer
Location:
10 B2; 10 22.89 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (42736314..42836778)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (42858077..42960782)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene SEC63 homolog, protein translocation regulator Neighboring gene STARR-seq mESC enhancer starr_26495 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:42582153-42582336 Neighboring gene predicted gene, 53623 Neighboring gene predicted gene, 34006 Neighboring gene STARR-seq mESC enhancer starr_26496 Neighboring gene STARR-positive B cell enhancer ABC_E6835 Neighboring gene STARR-seq mESC enhancer starr_26499 Neighboring gene STARR-positive B cell enhancer mm9_chr10:42709746-42710047 Neighboring gene predicted gene, 51402 Neighboring gene predicted gene 5079 Neighboring gene STARR-seq mESC enhancer starr_26500 Neighboring gene sine oculis binding protein Neighboring gene predicted gene, 47815

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fatty Acids Support the Fitness and Functionality of Tumor-Resident CD8+ T Cells by Maintaining SCML4 Expression. Feng M, et al. Cancer Res, 2023 Oct 13. PMID 37610617
  2. The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS. Tedeschi A, et al. Neuron, 2016 Oct 19. PMID 27720483
  3. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
  4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC49264

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sex comb on midleg-like protein 4
Names
sex comb on midleg-like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359264.1 → NP_001346193.1  sex comb on midleg-like protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125206, AI510183, AK034171, AK047972, CB521445
    Conserved Domains (3) summary
    cd09578
    Location:416 → 487
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    pfam12140
    Location:177 → 285
    SLED; SLED domain
    pfam17208
    Location:83 → 142
    RBR; RNA binding Region

  2. NM_001359265.1 → NP_001346194.1  sex comb on midleg-like protein 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC125206, AI510183, AK034171, AK047972, CB521445
    Consensus CDS
    CCDS87999.1
    Related
    ENSMUSP00000101133.2, ENSMUST00000105494.8
    Conserved Domains (2) summary
    cd09578
    Location:276 → 347
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    pfam12140
    Location:37 → 145
    SLED; SLED domain

  3. NM_001359266.1 → NP_001346195.1  sex comb on midleg-like protein 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC125206, AK034171
    Consensus CDS
    CCDS87998.1
    UniProtKB/TrEMBL
    D3Z791
    Related
    ENSMUSP00000101134.2, ENSMUST00000105495.8
    Conserved Domains (2) summary
    pfam12140
    Location:95 → 162
    SLED; SLED domain
    pfam17208
    Location:1 → 60
    RBR; RNA binding Region

  4. NM_172938.3 → NP_766526.3  sex comb on midleg-like protein 4 isoform 2

    See identical proteins and their annotated locations for NP_766526.3

    Status: VALIDATED

    Source sequence(s)
    AC125206, AK034171, AK220309
    Consensus CDS
    CCDS23816.1
    UniProtKB/Swiss-Prot
    Q3TA16, Q3V358, Q5DU61, Q80VG1, Q8CC08
    Related
    ENSMUSP00000053157.8, ENSMUST00000063063.14
    Conserved Domains (3) summary
    cd09578
    Location:334 → 405
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    smart00454
    Location:337 → 405
    SAM; Sterile alpha motif
    pfam12140
    Location:95 → 204
    DUF3588; Protein of unknown function (DUF3588)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    42736314..42836778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155790.1 → XP_036011683.1  sex comb on midleg-like protein 4 isoform X3

    Conserved Domains (2) summary
    pfam12140
    Location:177 → 244
    SLED; SLED domain
    pfam17208
    Location:83 → 142
    RBR; RNA binding Region

  2. XM_006512752.5 → XP_006512815.1  sex comb on midleg-like protein 4 isoform X2

    Conserved Domains (3) summary
    cd09578
    Location:351 → 422
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    pfam12140
    Location:177 → 246
    SLED; SLED domain
    pfam17208
    Location:83 → 142
    RBR; RNA binding Region

  3. XM_006512751.5 → XP_006512814.1  sex comb on midleg-like protein 4 isoform X1

    Conserved Domains (3) summary
    cd09578
    Location:381 → 452
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    pfam12140
    Location:142 → 250
    SLED; SLED domain
    pfam17208
    Location:48 → 107
    RBR; RNA binding Region

  4. XM_017313950.3 → XP_017169439.1  sex comb on midleg-like protein 4 isoform X4

    UniProtKB/TrEMBL
    Q3UR41
    Conserved Domains (2) summary
    cd09578
    Location:92 → 163
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    pfam04484
    Location:36 → 109
    QWRF; QWRF family

  5. XM_006512757.4 → XP_006512820.1  sex comb on midleg-like protein 4 isoform X4

    See identical proteins and their annotated locations for XP_006512820.1

    UniProtKB/TrEMBL
    Q3UR41
    Conserved Domains (2) summary
    cd09578
    Location:92 → 163
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    pfam04484
    Location:36 → 109
    QWRF; QWRF family

  6. XM_006512755.4 → XP_006512818.1  sex comb on midleg-like protein 4 isoform X4

    See identical proteins and their annotated locations for XP_006512818.1

    UniProtKB/TrEMBL
    Q3UR41
    Conserved Domains (2) summary
    cd09578
    Location:92 → 163
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    pfam04484
    Location:36 → 109
    QWRF; QWRF family

  7. XM_006512756.5 → XP_006512819.1  sex comb on midleg-like protein 4 isoform X4

    See identical proteins and their annotated locations for XP_006512819.1

    UniProtKB/TrEMBL
    Q3UR41
    Conserved Domains (2) summary
    cd09578
    Location:92 → 163
    SAM_Scm; SAM domain of Scm proteins of Polycomb group
    pfam04484
    Location:36 → 109
    QWRF; QWRF family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80VG1.2 GenPept UniProtKB/Swiss-Prot:Q80VG1

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