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Rab11fip4 RAB11 family interacting protein 4 (class II) [ Mus musculus (house mouse) ]

Gene ID: 268451, updated on 2-Nov-2024

Summary

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Official Symbol
Rab11fip4provided by MGI
Official Full Name
RAB11 family interacting protein 4 (class II)provided by MGI
Primary source
MGI:MGI:2442920
See related
Ensembl:ENSMUSG00000017639 AllianceGenome:MGI:2442920
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1821; RAB11-FIP4; A730072L08Rik
Summary
Predicted to enable protein homodimerization activity and small GTPase binding activity. Predicted to be involved in endocytic recycling and regulation of cytokinesis. Predicted to be located in endosome. Predicted to be active in cleavage furrow; cytoplasmic vesicle; and midbody. Is expressed in several structures, including central nervous system; gut; respiratory system; sensory organ; and skeleton. Orthologous to human RAB11FIP4 (RAB11 family interacting protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cortex adult (RPKM 31.5), frontal lobe adult (RPKM 30.4) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Rab11fip4 in Genome Data Viewer
Location:
11 B5; 11 46.88 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (79481847..79588842)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (79591021..79698016)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene neurofibromin 1 Neighboring gene STARR-positive B cell enhancer ABC_E8431 Neighboring gene STARR-positive B cell enhancer ABC_E7024 Neighboring gene STARR-positive B cell enhancer ABC_E5254 Neighboring gene STARR-positive B cell enhancer ABC_E11485 Neighboring gene ecotropic viral integration site 2b Neighboring gene ecotropic viral integration site 2 Neighboring gene ecotropic viral integration site 2a Neighboring gene STARR-positive B cell enhancer ABC_E11768 Neighboring gene RAB11 family interacting protein 4 (class II), opposite strand 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:79428461-79428644 Neighboring gene predicted gene, 23293 Neighboring gene STARR-seq mESC enhancer starr_30126 Neighboring gene predicted gene, 25867 Neighboring gene predicted gene, 30718 Neighboring gene predicted gene, 24887 Neighboring gene RAB11 family interacting protein 4 (class II), opposite strand 2 Neighboring gene STARR-positive B cell enhancer ABC_E9141 Neighboring gene nuclear encoded tRNA threonine 3 (anticodon CGT) Neighboring gene predicted gene 11205 Neighboring gene microRNA 193a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FIP4/Arfophilin-2 plays overlapping but distinct roles from FIP3/Arfophilin-1 in neuronal migration during cortical layer formation. Hara Y, et al. Eur J Neurosci, 2018 Nov. PMID 30295969
  2. Hypoxia-induced Rab11-family interacting protein 4 expression promotes migration and invasion of colon cancer and correlates with poor prognosis. Wang JZ, et al. Mol Med Rep, 2018 Mar. PMID 29257314
  3. ADP Ribosylation Factor 6 Regulates Neuronal Migration in the Developing Cerebral Cortex through FIP3/Arfophilin-1-dependent Endosomal Trafficking of N-cadherin. Hara Y, et al. eNeuro, 2016 Jul-Aug. PMID 27622210, Free PMC Article
  4. Mouse Rab11-FIP4 regulates proliferation and differentiation of retinal progenitors in a Rab11-independent manner. Muto A, et al. Dev Dyn, 2007 Jan. PMID 17089410
  5. Evidence by expression analysis of candidate genes for congenital heart defects in the NF1 microdeletion interval. Venturin M, et al. Ann Hum Genet, 2005 Sep. PMID 16138909

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FIP4 and FIP3 play overlapping but distinct roles in neuronal migration downstream of Rab11 and Arfophilin-1 during cortical layer formation.
    Title: FIP4/Arfophilin-2 plays overlapping but distinct roles from FIP3/Arfophilin-1 in neuronal migration during cortical layer formation.
  2. Rab11-FIP4 expression promotes migration and invasion of colon cancer cells and correlates with poor prognosis.
    Title: Hypoxia-induced Rab11-family interacting protein 4 expression promotes migration and invasion of colon cancer and correlates with poor prognosis.
  3. identification of Rab11-family interacting protein 4 (Rab11-FIP4) as a gene strongly expressed in the developing mouse retina.
    Title: Mouse Rab11-FIP4 regulates proliferation and differentiation of retinal progenitors in a Rab11-independent manner.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1821

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cleavage furrow IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
  
located_in cleavage furrow ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in endocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in recycling endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in recycling endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
rab11 family-interacting protein 4
Names
FIP4-Rab11
mRab11-FIP4A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175543.3 → NP_780752.1  rab11 family-interacting protein 4

    See identical proteins and their annotated locations for NP_780752.1

    Status: PROVISIONAL

    Source sequence(s)
    AK046734
    Consensus CDS
    CCDS25123.1
    UniProtKB/Swiss-Prot
    Q80T87, Q8BQP8
    Related
    ENSMUSP00000017783.7, ENSMUST00000017783.13
    Conserved Domains (3) summary
    pfam09457
    Location:594 → 634
    RBD-FIP; FIP domain
    pfam13499
    Location:21 → 78
    EF-hand_7; EF-hand domain pair
    cl03075
    Location:426 → 510
    GrpE; nucleotide exchange factor GrpE

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    79481847..79588842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533403.2 → XP_006533466.1  rab11 family-interacting protein 4 isoform X1

    Conserved Domains (3) summary
    COG1196
    Location:315 → 545
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09457
    Location:571 → 611
    RBD-FIP; FIP domain
    pfam13499
    Location:20 → 78
    EF-hand_7; EF-hand domain pair

  2. XM_036156717.1 → XP_036012610.1  rab11 family-interacting protein 4 isoform X2

    Conserved Domains (2) summary
    TIGR02168
    Location:278 → 560
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam09457
    Location:535 → 575
    RBD-FIP; FIP domain

  3. XM_036156719.1 → XP_036012612.1  rab11 family-interacting protein 4 isoform X5

    Conserved Domains (1) summary
    pfam13499
    Location:20 → 78
    EF-hand_7; EF-hand domain pair

  4. XM_030246035.2 → XP_030101895.1  rab11 family-interacting protein 4 isoform X4

    Conserved Domains (2) summary
    COG1196
    Location:199 → 429
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09457
    Location:455 → 495
    RBD-FIP; FIP domain

  5. XM_006533404.4 → XP_006533467.1  rab11 family-interacting protein 4 isoform X3

    Conserved Domains (2) summary
    COG1196
    Location:236 → 466
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09457
    Location:492 → 532
    RBD-FIP; FIP domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BQP8.1 GenPept UniProtKB/Swiss-Prot:Q8BQP8

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