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Rapgefl1 Rap guanine nucleotide exchange factor (GEF)-like 1 [ Mus musculus (house mouse) ]

Gene ID: 268480, updated on 2-Nov-2024

Summary

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Official Symbol
Rapgefl1provided by MGI
Official Full Name
Rap guanine nucleotide exchange factor (GEF)-like 1provided by MGI
Primary source
MGI:MGI:3611446
See related
Ensembl:ENSMUSG00000038020 AllianceGenome:MGI:3611446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B230105J10
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be active in plasma membrane. Orthologous to human RAPGEFL1 (Rap guanine nucleotide exchange factor like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in colon adult (RPKM 41.7), frontal lobe adult (RPKM 28.2) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Rapgefl1 in Genome Data Viewer
Location:
11 D; 11 62.7 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98727611..98744519)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98836785..98853009)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12359 Neighboring gene male specific lethal 1 Neighboring gene STARR-positive B cell enhancer ABC_E5276 Neighboring gene exon junction complex subunit Neighboring gene STARR-positive B cell enhancer ABC_E9145 Neighboring gene WAS/WASL interacting protein family, member 2 Neighboring gene VISTA enhancer mm1323 Neighboring gene STARR-positive B cell enhancer ABC_E203 Neighboring gene cell division cycle 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
  2. ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor β1. Wang W, et al. Biochem Biophys Res Commun, 2021 Oct 22. PMID 34474245, Free PMC Article
  3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rap guanine nucleotide exchange factor-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080925.1 → NP_001074394.1  rap guanine nucleotide exchange factor-like 1

    See identical proteins and their annotated locations for NP_001074394.1

    Status: VALIDATED

    Source sequence(s)
    AL590963
    Consensus CDS
    CCDS36303.1
    UniProtKB/Swiss-Prot
    A1L3T1, Q68EF8
    Related
    ENSMUSP00000103103.3, ENSMUST00000107479.3
    Conserved Domains (1) summary
    smart00147
    Location:420 → 658
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    98727611..98744519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533411.4 → XP_006533474.1  rap guanine nucleotide exchange factor-like 1 isoform X1

    Conserved Domains (1) summary
    smart00147
    Location:150 → 388
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68EF8.2 GenPept UniProtKB/Swiss-Prot:Q68EF8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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