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Krt12 keratin 12 [ Mus musculus (house mouse) ]

Gene ID: 268482, updated on 2-Nov-2024

Summary

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Official Symbol
Krt12provided by MGI
Official Full Name
keratin 12provided by MGI
Primary source
MGI:MGI:96687
See related
Ensembl:ENSMUSG00000020912 AllianceGenome:MGI:96687
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
K12; Krt-12; Krt1-12
Summary
Predicted to enable structural molecule activity. Involved in cornea development in camera-type eye and morphogenesis of an epithelium. Acts upstream of or within epithelium development. Predicted to be located in intermediate filament. Predicted to be active in cytoskeleton. Is expressed in cornea; cornea epithelium; head; lower jaw molar; and upper jaw molar. Used to study Meesmann corneal dystrophy. Human ortholog(s) of this gene implicated in Meesmann corneal dystrophy 1 and corneal dystrophy. Orthologous to human KRT12 (keratin 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 12.9), frontal lobe adult (RPKM 10.8) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Krt12 in Genome Data Viewer
Location:
11 D; 11 62.92 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (99306490..99313419, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (99415664..99422593, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene keratin 28 Neighboring gene STARR-positive B cell enhancer mm9_chr11:99247019-99247320 Neighboring gene STARR-positive B cell enhancer mm9_chr11:99247331-99247631 Neighboring gene keratin 10 Neighboring gene RIKEN cDNA A830036E02 gene Neighboring gene keratin 20 Neighboring gene keratin 23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cornea-specific expression of K12 keratin during mouse development. Liu CY, et al. Curr Eye Res, 1993 Nov. PMID 7508359
  2. Characterization and chromosomal localization of the cornea-specific murine keratin gene Krt1.12. Liu CY, et al. J Biol Chem, 1994 Oct 7. PMID 7523376
  3. Targeted overexpression of TGF-α in the corneal epithelium of adult transgenic mice induces changes in anterior segment morphology and activates noncanonical Wnt signaling. Yuan Y, et al. Invest Ophthalmol Vis Sci, 2013 Mar 11. PMID 23412089, Free PMC Article
  4. Conjunctival epithelial cells can resurface denuded cornea, but do not transdifferentiate to express cornea-specific keratin 12 following removal of limbal epithelium in mouse. Moyer PD, et al. Differentiation, 1996 Mar. PMID 8935926
  5. Corneal epithelium-specific mouse keratin K12 promoter. Liu JJ, et al. Exp Eye Res, 1999 Mar. PMID 10079137

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data revealed that the early corneal epithelial progenitor cells expressing keratin-12 originated from limbus, and gave rise to the transit amplifying cells that migrated centripetally to differentiate into corneal epithelial cells
    Title: Study of corneal epithelial progenitor origin and the Yap1 requirement using keratin 12 lineage tracing transgenic mice.
  2. clonal limbal stem cells randomly activate Krt12 alleles in the process of terminal differentiation in cornea
    Title: Monoallelic expression of Krt12 gene during corneal-type epithelium differentiation of limbal stem cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cornea development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cornea development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cornea development in camera-type eye ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within epithelium development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in morphogenesis of an epithelium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in morphogenesis of an epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in morphogenesis of an epithelium ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
keratin, type I cytoskeletal 12
Names
CK-12
Keratin, type I cytoskeletal 12 (Cytokeratin 12)
cytokeratin-12
keratin complex 1, acidic, gene 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010661.2 → NP_034791.2  keratin, type I cytoskeletal 12

    Status: VALIDATED

    Source sequence(s)
    AK053362, AK143182, AL591165, CK627700
    Consensus CDS
    CCDS36306.1
    UniProtKB/Swiss-Prot
    A2A514, A2RRZ0, Q64291
    UniProtKB/TrEMBL
    Z4YJD9
    Related
    ENSMUSP00000017741.4, ENSMUST00000017741.4
    Conserved Domains (1) summary
    pfam00038
    Location:118 → 428
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    99306490..99313419 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533413.2 → XP_006533476.1  keratin, type I cytoskeletal 12 isoform X1

    Conserved Domains (1) summary
    pfam00038
    Location:1 → 220
    Filament; Intermediate filament protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64291.2 GenPept UniProtKB/Swiss-Prot:Q64291

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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