U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sntg2 syntrophin, gamma 2 [ Mus musculus (house mouse) ]

Gene ID: 268534, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Sntg2provided by MGI
Official Full Name
syntrophin, gamma 2provided by MGI
Primary source
MGI:MGI:1919541
See related
Ensembl:ENSMUSG00000020672 AllianceGenome:MGI:1919541
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Syn5; G2syn; 9530013L23; 2210008K22Rik
Summary
Predicted to enable PDZ domain binding activity and neuroligin family protein binding activity. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of dystrophin-associated glycoprotein complex. Is expressed in gut and urinary system. Orthologous to human SNTG2 (syntrophin gamma 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in bladder adult (RPKM 13.2), colon adult (RPKM 3.0) and 8 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Sntg2 in Genome Data Viewer
Location:
12 A2; 12 13.0 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (30224481..30423424, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (30174482..30373392, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40873 Neighboring gene predicted gene, 32084 Neighboring gene RIKEN cDNA 2310016D03 gene Neighboring gene receptor-like tyrosine kinase, pseudogene 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. gamma-Syntrophin scaffolding is spatially and functionally distinct from that of the alpha/beta syntrophins. Alessi A, et al. Exp Cell Res, 2006 Oct 1. PMID 16857187
  2. Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction. Chen Z, et al. J Biol Chem, 2006 May 5. PMID 16533813
  3. Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome. Lyssand JS, et al. J Biol Chem, 2008 Jul 4. PMID 18468998, Free PMC Article
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding IEA
Inferred from Electronic Annotation
more info
  
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables neuroligin family protein binding IEA
Inferred from Electronic Annotation
more info
  
enables neuroligin family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of dystrophin-associated glycoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
gamma-2-syntrophin
Names
syntrophin-5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324519.1 → NP_001311448.1  gamma-2-syntrophin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157276, AC159628
    UniProtKB/TrEMBL
    Q8BZG8
    Conserved Domains (1) summary
    cd00992
    Location:18 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  2. NM_001324520.1 → NP_001311449.1  gamma-2-syntrophin isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC157276, AC159628, AK008673, AK087560, BY098098
    UniProtKB/TrEMBL
    Q8BZG8

  3. NM_001324521.1 → NP_001311450.1  gamma-2-syntrophin isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC159628, AK087560, BC058204, BY098098

  4. NM_172951.3 → NP_766539.2  gamma-2-syntrophin isoform 1

    See identical proteins and their annotated locations for NP_766539.2

    Status: VALIDATED

    Source sequence(s)
    AK035310, AK087560, BC138956, BY098098
    Consensus CDS
    CCDS25858.1
    UniProtKB/Swiss-Prot
    B2RSQ0, Q925E0
    UniProtKB/TrEMBL
    Q8BZG8
    Related
    ENSMUSP00000021004.8, ENSMUST00000021004.14
    Conserved Domains (1) summary
    cd00992
    Location:72 → 153
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RNA

  1. NR_136915.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159628, AK087560, BY098098
    Related
    ENSMUST00000142046.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    30224481..30423424 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315072.2 → XP_017170561.1  gamma-2-syntrophin isoform X2

    Conserved Domains (1) summary
    cd00992
    Location:18 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  2. XM_006515108.2 → XP_006515171.1  gamma-2-syntrophin isoform X1

    UniProtKB/TrEMBL
    Q8BZG8
    Conserved Domains (1) summary
    cd00992
    Location:72 → 153
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  3. XM_011243873.1 → XP_011242175.1  gamma-2-syntrophin isoform X3

RNA

  1. XR_872414.2 RNA Sequence

    Related
    ENSMUST00000133324.8

  2. XR_003950053.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q925E0.1 GenPept UniProtKB/Swiss-Prot:Q925E0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools