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RNU1-2 RNA, U1 small nuclear 2 [ Homo sapiens (human) ]

Gene ID: 26870, updated on 2-Nov-2024

Summary

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Official Symbol
RNU1-2provided by HGNC
Official Full Name
RNA, U1 small nuclear 2provided by HGNC
Primary source
HGNC:HGNC:10123
See related
Ensembl:ENSG00000207005 AllianceGenome:HGNC:10123
Gene type
snRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
U1C1; U1C21; RNU1C1; RNU1C2
Summary
Predicted to enable pre-mRNA 5'-splice site binding activity. Predicted to be involved in mRNA 5'-splice site recognition. Predicted to be part of U1 snRNP. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RNU1-2 in Genome Data Viewer
Location:
1p36.13
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (16895980..16896143)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (16706420..16706583)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (17222475..17222638)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985101 Neighboring gene uncharacterized LOC105376805 Neighboring gene tRNA-Asn (anticodon GTT) 4-1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17221837-17222770 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17222771-17223703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 271 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17230789-17231428 Neighboring gene Sharpr-MPRA regulatory region 252 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 337 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17247068-17247840 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17247841-17248612 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17248613-17249384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:17249385-17250156 Neighboring gene ciliary rootlet coiled-coil, rootletin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:17250340-17250950 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:17252780-17253390 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:17259505-17259699 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 338 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17298533-17299510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:17300945-17301752 Neighboring gene uncharacterized LOC105376806 Neighboring gene microfibril associated protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Human U1 small nuclear RNA genes: extensive conservation of flanking sequences suggests cycles of gene amplification and transposition. Bernstein LB, et al. Mol Cell Biol, 1985 Sep. PMID 3837185, Free PMC Article
  2. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. Choudhury NR, et al. BMC Biol, 2017 Nov 8. PMID 29117863, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Other Names

  • RNA, U1C1 small nuclear
  • RNA, U1C2 small nuclear

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_004427.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BX284668
    Related
    ENST00000384278.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    16895980..16896143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791756.1 Reference GRCh38.p14 PATCHES

    Range
    1311133..1311296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    16706420..16706583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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