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Atp13a5 ATPase type 13A5 [ Mus musculus (house mouse) ]

Gene ID: 268878, updated on 2-Nov-2024

Summary

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Official Symbol
Atp13a5provided by MGI
Official Full Name
ATPase type 13A5provided by MGI
Primary source
MGI:MGI:2444068
See related
Ensembl:ENSMUSG00000048939 AllianceGenome:MGI:2444068
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C630015F21Rik
Summary
Predicted to enable ATPase-coupled monoatomic cation transmembrane transporter activity and polyamine transmembrane transporter activity. Predicted to be involved in intracellular calcium ion homeostasis and polyamine transmembrane transport. Predicted to be located in membrane. Predicted to be active in late endosome membrane. Is expressed in several structures, including dentate gyrus subgranular zone; lung; musculature; sensory organ; and urinary system. Orthologous to human ATP13A5 (ATPase 13A5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 2.3), frontal lobe adult (RPKM 2.2) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Atp13a5 in Genome Data Viewer
Location:
16 B2; 16 20.03 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (29049242..29208807, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (29230490..29378766, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene Mab-21 domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_40518 Neighboring gene STARR-seq mESC enhancer starr_40520 Neighboring gene predicted gene 8253 Neighboring gene STARR-seq mESC enhancer starr_40521 Neighboring gene phospholipase A and acyltransferase 1 Neighboring gene STARR-seq mESC enhancer starr_40522 Neighboring gene STARR-seq mESC enhancer starr_40523 Neighboring gene ATPase type 13A4 Neighboring gene zinc finger protein 788 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:29579308-29579525 Neighboring gene STARR-seq mESC enhancer starr_40527 Neighboring gene OPA1, mitochondrial dynamin like GTPase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the P5 subfamily of P-type transport ATPases in mice. Schultheis PJ, et al. Biochem Biophys Res Commun, 2004 Oct 22. PMID 15381061
  2. A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cells. Shah K, et al. J Mol Cell Biol, 2020 Jan 22. PMID 31065682, Free PMC Article
  3. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article
  4. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled monoatomic cation transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase-coupled monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type ion transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables polyamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in polyamine transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable cation-transporting ATPase 13A5
Names
P5-ATPase
NP_001271304.1
NP_783581.2
XP_006522259.1
XP_036015848.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284375.1 → NP_001271304.1  probable cation-transporting ATPase 13A5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region compared to variant 1. This results in a shorter isoform (2), when compared to isoform 1.
    Source sequence(s)
    AC154421, AC175464, BC115739, CB524474
    Consensus CDS
    CCDS70705.1
    UniProtKB/TrEMBL
    D3YU82
    Related
    ENSMUSP00000121208.2, ENSMUST00000143373.8
    Conserved Domains (6) summary
    TIGR01657
    Location:24 → 1073
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
    pfam00122
    Location:206 → 426
    E1-E2_ATPase; E1-E2 ATPase
    pfam00690
    Location:170 → 202
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12409
    Location:23 → 137
    P5-ATPase; P5-type ATPase cation transporter
    pfam13246
    Location:549 → 592
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:778 → 828
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  2. NM_175650.4 → NP_783581.2  probable cation-transporting ATPase 13A5 isoform 1

    See identical proteins and their annotated locations for NP_783581.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK083121, AK158355
    Consensus CDS
    CCDS28095.1
    UniProtKB/Swiss-Prot
    Q14BM0, Q3TYU2, Q8BUP1
    Related
    ENSMUSP00000075204.5, ENSMUST00000075806.11
    Conserved Domains (6) summary
    TIGR01657
    Location:24 → 1118
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
    pfam00122
    Location:228 → 471
    E1-E2_ATPase; E1-E2 ATPase
    pfam00690
    Location:170 → 239
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12409
    Location:23 → 137
    P5-ATPase; P5-type ATPase cation transporter
    pfam13246
    Location:594 → 637
    Cation_ATPase; Cation transport ATPase (P-type)
    cl21460
    Location:823 → 873
    HAD_like; Haloacid Dehalogenase-like Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    29049242..29208807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159955.1 → XP_036015848.1  probable cation-transporting ATPase 13A5 isoform X2

    Conserved Domains (2) summary
    cd07542
    Location:156 → 981
    P-type_ATPase_cation; P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p
    pfam12409
    Location:3 → 124
    P5-ATPase; P5-type ATPase cation transporter

  2. XM_006522196.5 → XP_006522259.1  probable cation-transporting ATPase 13A5 isoform X1

    Conserved Domains (2) summary
    cd07542
    Location:160 → 985
    P-type_ATPase_cation; P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p
    pfam12409
    Location:23 → 137
    P5-ATPase; P5-type ATPase cation transporter
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TYU2.2 GenPept UniProtKB/Swiss-Prot:Q3TYU2

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