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Stk36 serine/threonine kinase 36 [ Mus musculus (house mouse) ]

Gene ID: 269209, updated on 2-Nov-2024

Summary

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Official Symbol
Stk36provided by MGI
Official Full Name
serine/threonine kinase 36provided by MGI
Primary source
MGI:MGI:1920831
See related
Ensembl:ENSMUSG00000033276 AllianceGenome:MGI:1920831
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FU; Fused; mKIAA1278; B930045J24; 1700112N14Rik
Summary
Predicted to enable protein serine/threonine kinase activity and transcription corepressor binding activity. Involved in several processes, including cilium assembly; positive regulation of smoothened signaling pathway; and smoothened signaling pathway. Acts upstream of or within brain development and epithelial cilium movement involved in extracellular fluid movement. Located in cytoplasm. Is expressed in several structures, including central nervous system; sensory organ; skeleton; tail somite; and testis. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human STK36 (serine/threonine kinase 36). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 49.4), whole brain E14.5 (RPKM 6.3) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Stk36 in Genome Data Viewer
Location:
1 C4; 1 38.54 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74640583..74676053)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74601391..74636894)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E791 Neighboring gene BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone Neighboring gene ring finger protein 25 Neighboring gene STARR-seq mESC enhancer starr_01341 Neighboring gene tubulin tyrosine ligase-like family, member 4 Neighboring gene cytochrome P450, family 27, subfamily a, polypeptide 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fused (Stk36) is a ciliary protein required for central pair assembly and motile cilia orientation in the mammalian oviduct. Nozawa YI, et al. Dev Dyn, 2013 Nov. PMID 23907739
  2. ULK4 and Fused/STK36 interact to mediate assembly of a motile flagellum. McCoy CJ, et al. Mol Biol Cell, 2023 Jun 1. PMID 36989043, Free PMC Article
  3. A possible role of mouse Fused (STK36) in Hedgehog signaling and Gli transcription factor regulation. Maloveryan A, et al. J Cell Commun Signal, 2007 Dec. PMID 18600476, Free PMC Article
  4. G(s)alpha deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency. Chen M, et al. Am J Physiol Cell Physiol, 2009 Apr. PMID 19158402, Free PMC Article
  5. Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development. Chen MH, et al. Mol Cell Biol, 2005 Aug. PMID 16055716, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ULK4 and Fused/STK36 interact to mediate assembly of a motile flagellum.
    Title: ULK4 and Fused/STK36 interact to mediate assembly of a motile flagellum.
  2. Fused (Stk36) is a ciliary protein required for central pair assembly and motile cilia orientation in the mammalian oviduct.
    Title: Fused (Stk36) is a ciliary protein required for central pair assembly and motile cilia orientation in the mammalian oviduct.
  3. Hydrocephalus and suppurative otitis media indicate dysfunction of motile cilia in Stk36 null mice
    Title: Congenital hydrocephalus in genetically engineered mice.
  4. mouse Fu is essential for construction of the central pair apparatus of motile, 9+2 cilia
    Title: Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis.
  5. This growth inhibition is partially rescued by expression of ectopic Gli1, suggesting that Fu may contribute to enhance Hh signaling activity in cancer cells.
    Title: Fused kinase is stabilized by Cdc37/Hsp90 and enhances Gli protein levels.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1278, MGC58023

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in axoneme assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in axoneme assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of smoothened signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in post-embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in smoothened signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in smoothened signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 36
Names
fused homolog
serine/threonine kinase 36 (fused homolog, Drosophila)
NP_001391006.1
NP_001391007.1
NP_778196.2
XP_036021382.1
XP_036021383.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001404077.1 → NP_001391006.1  serine/threonine-protein kinase 36 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117610

  2. NM_001404078.1 → NP_001391007.1  serine/threonine-protein kinase 36 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117610
    Related
    ENSMUSP00000084433.5, ENSMUST00000087186.11

  3. NM_175031.4 → NP_778196.2  serine/threonine-protein kinase 36 isoform 1

    See identical proteins and their annotated locations for NP_778196.2

    Status: VALIDATED

    Source sequence(s)
    AC117610
    Consensus CDS
    CCDS35619.1
    UniProtKB/Swiss-Prot
    Q69ZM6, Q6PDI0, Q80XQ6
    Related
    ENSMUSP00000084430.5, ENSMUST00000087183.11
    Conserved Domains (2) summary
    smart00220
    Location:4 → 254
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14002
    Location:2 → 254
    STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36

RNA

  1. NR_175802.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117610

  2. NR_175803.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117610
    Related
    ENSMUST00000145673.8

  3. NR_175804.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117610

  4. NR_175805.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117610

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    74640583..74676053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165489.1 → XP_036021382.1  serine/threonine-protein kinase 36 isoform X2

    Conserved Domains (1) summary
    cd14002
    Location:2 → 254
    STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36

  2. XM_036165490.1 → XP_036021383.1  serine/threonine-protein kinase 36 isoform X3

    Conserved Domains (4) summary
    COG1413
    Location:907 → 1152
    HEAT; HEAT repeat [General function prediction only]
    sd00044
    Location:962 → 989
    HEAT; HEAT repeat [structural motif]
    pfam13646
    Location:1028 → 1123
    HEAT_2; HEAT repeats
    cl21453
    Location:10 → 118
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69ZM6.3 GenPept UniProtKB/Swiss-Prot:Q69ZM6

Gene LinkOut

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