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Muc15 mucin 15 [ Mus musculus (house mouse) ]

Gene ID: 269328, updated on 28-Oct-2024

Summary

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Official Symbol
Muc15provided by MGI
Official Full Name
mucin 15provided by MGI
Primary source
MGI:MGI:2442110
See related
Ensembl:ENSMUSG00000050808 AllianceGenome:MGI:2442110
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MUC-15; 4732460E09; D730046L02Rik
Summary
Predicted to be located in membrane. Is expressed in genitourinary system. Orthologous to human MUC15 (mucin 15, cell surface associated). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Restricted expression toward genital fat pad adult (RPKM 52.9) See more
Orthologs
human all
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Genomic context

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See Muc15 in Genome Data Viewer
Location:
2 E3; 2 56.75 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (110551839..110569882)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (110721494..110739537)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05369 Neighboring gene STARR-seq mESC enhancer starr_05370 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene STARR-seq mESC enhancer starr_05371 Neighboring gene STARR-seq mESC enhancer starr_05372 Neighboring gene solute carrier family 5 (sodium/glucose cotransporter), member 12 Neighboring gene predicted gene, 52522 Neighboring gene anoctamin 3 Neighboring gene STARR-seq mESC enhancer starr_05373 Neighboring gene POTE ankyrin domain family member 1 Neighboring gene RB1-inducible coiled-coil 1 pseudogene Neighboring gene olfactory receptor family 4 subfamily F member 52

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Downregulation of MUC15 by miR-183-5p.1 promotes liver tumor-initiating cells properties and tumorigenesis via regulating c-MET/PI3K/AKT/SOX2 axis. Han T, et al. Cell Death Dis, 2022 Mar 2. PMID 35236826, Free PMC Article
  2. Analysis of Pax6 contiguous gene deletions in the mouse, Mus musculus, identifies regions distinct from Pax6 responsible for extreme small-eye and belly-spotting phenotypes. Favor J, et al. Genetics, 2009 Aug. PMID 19474196, Free PMC Article
  3. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mucin-15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290786.1 → NP_001277715.1  mucin-15 isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK028832, AK142590, AL731779
    Consensus CDS
    CCDS71111.1
    UniProtKB/TrEMBL
    A2AHK7, Q505K5
    Related
    ENSMUSP00000106646.3, ENSMUST00000111017.9
    Conserved Domains (1) summary
    pfam15672
    Location:23 → 279
    Mucin15; Cell-membrane associated Mucin15

  2. NM_172979.3 → NP_766567.1  mucin-15 isoform a precursor

    See identical proteins and their annotated locations for NP_766567.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK028832, AK142590, AL731779
    Consensus CDS
    CCDS16513.1
    UniProtKB/Swiss-Prot
    Q3UQC4, Q6XYQ9, Q7TMH6, Q8C6Z1, Q8CE82
    UniProtKB/TrEMBL
    Q0VEM9, Q14AL4
    Related
    ENSMUSP00000106645.3, ENSMUST00000111016.9
    Conserved Domains (1) summary
    pfam15672
    Location:23 → 331
    Mucin15; Cell-membrane associated Mucin15

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    110551839..110569882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C6Z1.1 GenPept UniProtKB/Swiss-Prot:Q8C6Z1

Gene LinkOut

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