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Trpc7 transient receptor potential cation channel, subfamily C, member 7 [ Mus musculus (house mouse) ]

Gene ID: 26946, updated on 2-Nov-2024

Summary

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Official Symbol
Trpc7provided by MGI
Official Full Name
transient receptor potential cation channel, subfamily C, member 7provided by MGI
Primary source
MGI:MGI:1349470
See related
Ensembl:ENSMUSG00000021541 AllianceGenome:MGI:1349470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TRP7; Trrp8
Summary
The protein encoded by this gene is a member of the transient receptor potential channel family of proteins, which form six-transmembrane cation-permeable channels that are calcium permeant. Knock out mice are viable but display a reduction in the gamma wave activity that precedes seizure induction in response to a muscrarinic agonist, suggesting a functional role for this protein in initiation of seizures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression
Biased expression in CNS E18 (RPKM 2.1), frontal lobe adult (RPKM 1.3) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Trpc7 in Genome Data Viewer
Location:
13 B1; 13 30.27 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (56920911..57043778, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (56773098..56895968, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 32 Neighboring gene predicted gene, 52066 Neighboring gene STARR-seq mESC enhancer starr_34654 Neighboring gene STARR-seq mESC enhancer starr_34655 Neighboring gene predicted gene, 22777 Neighboring gene predicted gene, 40962

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Distinct Morphological and Behavioural Alterations in ENU-Induced Heterozygous Trpc7(K810Stop) Mutant Mice. Rathkolb B, et al. Genes (Basel), 2021 Oct 29. PMID 34828338, Free PMC Article
  2. TRPC7 regulates the electrophysiological functions of embryonic stem cell-derived cardiomyocytes. Liu X, et al. Stem Cell Res Ther, 2021 May 3. PMID 33941260, Free PMC Article
  3. Critical role of canonical transient receptor potential channel 7 in initiation of seizures. Phelan KD, et al. Proc Natl Acad Sci U S A, 2014 Aug 5. PMID 25049394, Free PMC Article
  4. Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx. Riccio A, et al. J Biol Chem, 2002 Apr 5. PMID 11805119
  5. Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. Okada T, et al. J Biol Chem, 1999 Sep 24. PMID 10488066

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Distinct Morphological and Behavioural Alterations in ENU-Induced Heterozygous Trpc7(K810Stop) Mutant Mice.
    Title: Distinct Morphological and Behavioural Alterations in ENU-Induced Heterozygous Trpc7(K810Stop) Mutant Mice.
  2. TRPC7 regulates the electrophysiological functions of embryonic stem cell-derived cardiomyocytes.
    Title: TRPC7 regulates the electrophysiological functions of embryonic stem cell-derived cardiomyocytes.
  3. The injury phase after myocardial infarcts occurs during reperfusion and is a consequence of calcium release from internal stores combined with calcium entry, leading to cell death. We identify canonical transient receptor potential channels (TRPC) 3/6/7 as the cation channels through which most of the damaging calcium enters cells to trigger their death, and we describe mechanisms activated during the injury phase.
    Title: Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries.
  4. TRPC7 is intimately involved in the initiation of seizures both in vitro and in vivo.
    Title: Critical role of canonical transient receptor potential channel 7 in initiation of seizures.
  5. These results demonstrate that the melanopsin-evoked depolarization in retinal ganglion cells is not mediated by either TRPC3, TRPC6 or TRPC7 channel subunits alone.
    Title: Intrinsic phototransduction persists in melanopsin-expressing ganglion cells lacking diacylglycerol-sensitive TRPC subunits.
  6. TRPC channels are necessary mediators of pathologic cardiac hypertrophy, in part through a calcineurin-NFAT signaling pathway
    Title: TRPC channels are necessary mediators of pathologic cardiac hypertrophy.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables inositol 1,4,5 trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in single fertilization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IC
Inferred by Curator
more info
 PubMed 
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
short transient receptor potential channel 7
Names
transient receptor potential protein homologue TRP7
transient receptor protein 7
transient receptor protein 8
NP_001289301.1
NP_001289302.1
NP_036165.1
XP_006517325.1
XP_006517326.1
XP_006517327.1
XP_036013952.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302372.1 → NP_001289301.1  short transient receptor potential channel 7 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AC132322, AC132886, AK135153, AK137418
    Consensus CDS
    CCDS79192.1
    UniProtKB/TrEMBL
    E9PVJ9, Q3UXW9
    Related
    ENSMUSP00000105497.2, ENSMUST00000109871.8
    Conserved Domains (5) summary
    cd00204
    Location:51 → 184
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:27 → 821
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:198 → 256
    TRP_2; Transient receptor ion channel II
    sd00045
    Location:77 → 108
    ANK; ANK repeat [structural motif]
    cl00511
    Location:582 → 665
    FTSW_RODA_SPOVE; Cell cycle protein

  2. NM_001302373.1 → NP_001289302.1  short transient receptor potential channel 7 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream start codon compared to variant 1. It encodes isoform 3, which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC132886, AK135153, AK137418
    UniProtKB/TrEMBL
    Q3UXW9
    Conserved Domains (2) summary
    pfam00520
    Location:52 → 299
    Ion_trans; Ion transport protein
    cl00511
    Location:197 → 280
    FTSW_RODA_SPOVE; Cell cycle protein

  3. NM_012035.3 → NP_036165.1  short transient receptor potential channel 7 isoform 1

    See identical proteins and their annotated locations for NP_036165.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC132322, AC132886, AK135153, AK137418
    Consensus CDS
    CCDS26566.1
    UniProtKB/Swiss-Prot
    Q9WVC5
    UniProtKB/TrEMBL
    Q0VFY2, Q3UXW9
    Related
    ENSMUSP00000022023.7, ENSMUST00000022023.13
    Conserved Domains (5) summary
    cd00204
    Location:51 → 184
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:27 → 822
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:198 → 256
    TRP_2; Transient receptor ion channel II
    sd00045
    Location:77 → 108
    ANK; ANK repeat [structural motif]
    cl00511
    Location:582 → 665
    FTSW_RODA_SPOVE; Cell cycle protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    56920911..57043778 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517263.5 → XP_006517326.1  short transient receptor potential channel 7 isoform X3

    UniProtKB/TrEMBL
    G3UWT1
    Related
    ENSMUSP00000133411.2, ENSMUST00000173817.9
    Conserved Domains (2) summary
    TIGR00870
    Location:126 → 860
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:176 → 207
    ANK; ANK repeat [structural motif]

  2. XM_036158059.1 → XP_036013952.1  short transient receptor potential channel 7 isoform X2

    UniProtKB/TrEMBL
    G3UWI6
    Conserved Domains (2) summary
    TIGR00870
    Location:126 → 865
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:176 → 207
    ANK; ANK repeat [structural motif]

  3. XM_006517262.5 → XP_006517325.1  short transient receptor potential channel 7 isoform X1

    UniProtKB/TrEMBL
    G3UWI6
    Related
    ENSMUSP00000133305.2, ENSMUST00000174457.9
    Conserved Domains (2) summary
    TIGR00870
    Location:126 → 866
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:176 → 207
    ANK; ANK repeat [structural motif]

  4. XM_006517264.5 → XP_006517327.1  short transient receptor potential channel 7 isoform X4

    UniProtKB/TrEMBL
    G3UZW6
    Related
    ENSMUSP00000134662.3, ENSMUST00000173513.9
    Conserved Domains (2) summary
    TIGR00870
    Location:126 → 805
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:176 → 207
    ANK; ANK repeat [structural motif]

RNA

  1. XR_001780787.3 RNA Sequence

    Related
    ENSMUST00000151918.8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WVC5.1 GenPept UniProtKB/Swiss-Prot:Q9WVC5

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