Vat1 vesicle amine transport 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vat1provided by MGI
Official Full Name: vesicle amine transport 1provided by MGI
Primary source: MGI:MGI:1349450
See related: Ensembl:ENSMUSG00000034993 AllianceGenome:MGI:1349450
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: VAT-1
Summary: Predicted to enable oxidoreductase activity and zinc ion binding activity. Predicted to be involved in negative regulation of mitochondrial fusion. Predicted to be active in mitochondrial outer membrane. Is expressed in brain. Orthologous to human VAT1 (vesicle amine transport 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in duodenum adult (RPKM 120.2), lung adult (RPKM 104.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 65.1 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (101349574..101357025, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (101458748..101466199, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-34a and its target genes of FOXP2 and VAT1 are involved in dorsal root ganglia neuron damage under hyperglycemia.
Title: MiR-34a Regulates Axonal Growth of Dorsal Root Ganglia Neurons by Targeting FOXP2 and VAT1 in Postnatal and Adult Mouse.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of mitochondrial fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of mitochondrial fusion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial fusion	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: synaptic vesicle membrane protein VAT-1 homolog

Names: membrane protein of cholinergic synaptic vesicles; vesicle amine transport protein 1 homolog (T californica)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012037.2 → NP_036167.1 synaptic vesicle membrane protein VAT-1 homolog

See identical proteins and their annotated locations for NP_036167.1

Status: PROVISIONAL

Source sequence(s)

AK034795

Consensus CDS

CCDS25472.1

UniProtKB/Swiss-Prot

Q62465, Q8R3G0, Q8R3T8

UniProtKB/TrEMBL

Q3U331, Q499X4

Related

ENSMUSP00000048350.8, ENSMUST00000040430.8

Conserved Domains (1) summary

cd08275
Location:62 → 400

MDR3; Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family